Search results for "Delivery"
showing 10 items of 1271 documents
Building a Medical Research Cloud in the EASI-CLOUDS Project
2014
The demand for IT resources is constantly growing in the scientific area. The ability to store and process increasing amounts of data has transformed many research disciplines, like the life-sciences, which now rely on complex data processing and data analytics. Cloud environments are able to integrate and encapsulate possibly distributed resources and allow convenient and on-demand access to the corresponding services, tools, and complete work environments. The European research project EASI-CLOUDS (http://www. easi-clouds.eu) develops a platform for a convenient service delivery with special regard to service integration, monitoring, management, and Service Level Agreement (SLA) negotiati…
Protein materials as sustainable non- and minimally invasive strategies for biomedical applications
2022
Protein-based materials have found applications in a wide range of biomedical fields because of their biocompatibility, biodegradability and great versatility. Materials of different physical forms including particles, hydrogels, films, fibers and microneedles have been fabricated e.g. as carriers for drug delivery, factors to promote wound healing and as structural support for the generation of new tissue. This review aims at providing an overview of the current scientific knowledge on protein-based materials, and selected preclinical and clinical studies will be reviewed in depth as examples of the latest progress within the field of protein-based materials, specifically focusing on non- …
Mitigation of self-phase modulation by sinusoidally time varying phase
2018
The propagation of intense ultra-short optical pulses in a Kerr medium such as an optical fibre remains a critical issue for many optical systems. This is because the self-phase modulation (SPM) of the propagating pulse usually causes a severe broadening of the pulse spectrum that is typically accompanied by an oscillatory structure. Several strategies have been proposed and successfully deployed to counteract the deleterious effects of SPM in fiber-optic systems, including spatial or temporal scaling to reduce the impact of nonlinearity. Other approaches rely on the exploitation of the peculiar properties of parabolic shaped pulses and self-similar evolution. However, none of these last te…
Chapter 16 - Carbon Nanotubes: Synthesis, Characterization, and Applications in Drug-Delivery Systems
2019
International audience; Nanoparticles are increasingly being considered in the medical field as an effective means to deliver drugs of interest or as diagnostic biosensors. Carbon nanotubes (CNTs) are an allotropic form of carbon related to the fullerene family. Their exceptional thermal, mechanical, and electronical properties together with their tubular shape, offering a high surface area and enabling adsorption or conjugation of a wide variety of therapeutic drugs or diagnostic agents, make CNTs attractive platforms for the treatment of various diseases. This chapter reviews the emerging synthesis, characterization, and and discusses the perspectives and obstacles of these promising nano…
Theoretical use of boron nitride nanotubes as a perfect container for anticancer molecules
2016
International audience; In recent years great interest has emerged in the development of nanocarriers for drug transport. One of themajor challenges is to obtain a drug delivery system able to control the drug release profile, transportabsorption and distribution, in the view of improving efficacy and safety. Herein, we present theoreticalresults based on density functional theory (DFT) to determine the best adsorption site for the anticancerifosfamide molecule in boron nitride nanotubes. For this functionalized system we determine thedependence of the adsorption energy on the displacement of molecules in the outer and inner boronnitride surfaces, together with their local morphological and…
Ant Colony Optimization for an Adaptive Transportation System : A New Termination Condition Definition Using an Environment Based Approach
2020
The delivery of the packages following the online purchase of goods trough web giants platforms is growing faster each years. To meet the demand of the growing quantity ofpackages and their delivery, the algorithm used to resolve the Vehicle Routing Problem (VRP) has to be efficient and adaptive. The algorithms used to solve the VRP algorithm still provide better turn, but do not deal with situation adaptation at delivery point. Seeking to fit into this adaptive feature, the commitment of this paper is to lay solid groundwork for the development of an adaptive transportation system. Exploring various strategies taking care of the possibilities of delivery at delivery point, our objective is t…
GLYCOCLUSTER A BASE DI NANOTUBI DI ALLOSITE COME DRUG DELIVERY SYSTEM
2014
Le interazioni carboidrati–lectine giocano un ruolo fondamentale in diversi processi biologici come ad esempio nelle infiammazioni, embriogenesi, sviluppo cellulare, etc..1 Sebbene l’interazione tra lectine e carboidrati sia un’interazione debole, la possibilità di instaurare contemporaneamente interazioni multiple tra differenti unità di lectine e differenti unità di carboidrati ne aumenta l’efficienza e la selettività.2 Nella presente comunicazione si riporta la sintesi di nuovi glicocluster basati su nanotubi di allosite, a cui sono state chimicamente legate unità ciclodestriniche che presentano sul bordo largo unità zuccherine quali galattosio, mannosio e lattosio. I materiali ottenuti …
Photocrosslinking of dextran and polyaspartamide derivatives: a combination suitable for colon-specific drug delivery.
2007
Abstract The aim of this study was to prepare and characterize novel hydrogels with polysaccharide–polyaminoacid structure, able to undergo an enzymatic hydrolysis in the colon and potentially useful for treating inflammatory bowel diseases (IBD). Starting materials were methacrylated dextran (DEX-MA) and methacrylated α,β-poly(N-2-hydroxyethyl)- dl -aspartamide (PHM). These polymers were photocrosslinked by exposure of their aqueous solutions at 313 nm without photoinitiators. Different samples, shaped as microparticles, were obtained as a function of polymer concentration and irradiation time. FT-IR analysis confirmed the occurrence of a co-crosslinking between DEX-MA and PHM in all exper…
Chaperonopathies and chaperonotherapy. Hsp60 as therapeutic target in cancer: potential benefits and risks.
2013
In this minireview we focus on Hsp60 as a target for anticancer therapy. We discuss the new concepts of chaperonopathies and chaperonotherapy and present information on Hsp60 localization in the cell membrane of human tumor cells. We describe novel mechanisms for Hsp60 reaching the extracellular environment that involve membrane-associated stages, as well as data on anti-Hsp60 antibodies found in human sera, both in normal subjects and patients affected by autoimmune diseases. Finally, we discuss possible therapeutic applications of anti-Hsp60 antibodies in cancer treatment, evaluating also side effects on non-tumor cells. In conclusion, the way for investigating Hsp60-targeted anti-tumor t…