Search results for "Delta"
showing 10 items of 471 documents
Chemotherapy Sensitizes Colon Cancer Initiating Cells to Vγ9Vδ2 T Cell-Mediated Cytotoxicity
2013
Colon cancer comprises a small population of cancer initiating stem cells (CIC) that is responsible for tumor maintenance and resistance to anti-cancer therapies, possibly allowing for tumor recapitulation once treatment stops. Combinations of immune-based therapies with chemotherapy and other anti-tumor agents may be of significant clinical benefit in the treatment of colon cancer. However, cellular immune-based therapies have not been experimented yet in the population of colon CICs. Here, we demonstrate that treatment with low concentrations of commonly used chemotherapeutic agents, 5- fluorouracyl and doxorubicin, sensitize colon CICs to Vc9Vd2 T cell cytotoxicity. Vc9Vd2 T cell cytotox…
γδ T cells as a potential tool in colon cancer immunotherapy
2014
γδ T cells are capable of recognizing tumor cells and exert potent cellular cytotoxicity against a large range of tumors, including colon cancer. However, tumors utilize numerous strategies to escape recognition or killing by patrolling γδ T cells, such a downregulation of NKG2D ligands, MICA/B and ULBPs. Therefore, the combined upregulation of T-cell receptorand NKG2D ligands on tumor cells and induction of NKG2D expression on γδ T cells may greatly enhance tumor killing and unlock the functions of γδ T cells. Here, we briefly review current data on the mechanisms of γδ T-cell recognition and killing of colon cancer cells and propose that γδ T cells may represent a promising target for the…
Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes
2009
Colon cancer comprises a small population of cancer stem cells (CSC) that is responsible for tumor maintenance and resistant to cancer therapies, possibly allowing for tumor recapitulation once treatment stops. We previously demonstrated that such chemoresistance is mediated by autocrine production of IL-4 through the up-regulation of antiapoptotic proteins. Several innate and adaptive immune effector cells allow for the recognition and destruction of cancer precursors before they constitute the tumor mass. However, cellular immune-based therapies have not been experimented yet in the population of CSCs. Here, we show that the bisphosphonate zoledronate sensitizes colon CSCs to Vgamma9Vdelt…
γδ T cell-based anticancer immunotherapy: Progress and possibilities
2015
"Table 2" of "Study of ordered hadron chains with the ATLAS detector"
2017
The Delta(3h), for 3-hadron chains with mass below 0.59 GeV, as a function of $Q$, in the interval 0.02 GeV < Q < 0.36 GeV.
"Table 1" of "Measurements of the charge asymmetry in top-quark pair production in the dilepton final state at $\sqrt{s}=8$ TeV with the ATLAS detect…
2017
Unfolded distribution for the inclusive $\Delta|\eta|$ observable in the fiducial volume.
"Table 1" of "Study of ordered hadron chains with the ATLAS detector"
2017
The inclusive Delta as a function of $Q$, in the interval 0.02 GeV < Q < 2 GeV.
"Table 12" of "Constraints on jet quenching in p-Pb collisions at $\mathbf{\sqrt{s_{NN}}}$ = 5.02 TeV measured by the event-activity dependence of se…
2018
Ratio of event activity biased Delta_{recoil} distributions corresponding to recoil jets with R=0.4.
"Table 14" of "Constraints on jet quenching in p-Pb collisions at $\mathbf{\sqrt{s_{NN}}}$ = 5.02 TeV measured by the event-activity dependence of se…
2018
Ratio of event activity biased Delta_{recoil} distributions corresponding to recoil jets with R=0.2.
"Table 13" of "Constraints on jet quenching in p-Pb collisions at $\mathbf{\sqrt{s_{NN}}}$ = 5.02 TeV measured by the event-activity dependence of se…
2018
Ratio of event activity biased Delta_{recoil} distributions corresponding to recoil jets with R=0.2.