Search results for "Deme"

TORRE DI LONDRA: DEMENZA FRONTO-TEMPORALE E DISTURBO DELL’ UMORE

2008

PSEUDODEMENZA, DEPRESSIONE E DEMENZA

2008

DEMENZE E RISCHIO DI FRATTURE OSTEOPOROTICHE NEGLI ANZIANI. STUDIO OSSERVAZIONALE IN UN’UNITA’ VALUTATIVA ALZHEIMER (n°6) DI PALERMO

2008

DISTURBI DEL SONNO REM E NON-REM IN SOGGETTI AFFETTI DA DEMENZE DEGENERATIVE TAU-CORRELATE

2012

Functional Inactivation of pRB Results in Aneuploid Mammalian Cells After Release From a Mitotic Block

2002

AbstractThe widespread chromosome instability observed in tumors and in early stage carcinomas suggests that aneuploidy could be a prerequisite for cellular transformation and tumor initiation. Defects in tumor suppressers and genes that are part of mitotic checkpoints are likely candidates for the aneuploid phenotype. By using flow cytometric, cytogenetic, immunocytochemistry techniques we investigated whether pRB deficiency could drive perpetual aneuploidy in normal human and mouse fibroblasts after mitotic checkpoint challenge by microtubule-destabilizing drugs. Both mouse and human pRB-deficient primary fibroblasts resulted, upon release from a mitotic block, in proliferating aneuploid …

Comprehensive DNA methylation analysis of the Aedes aegypti genome

2016

AbstractAedes aegypti mosquitoes are important vectors of viral diseases. Mosquito host factors play key roles in virus control and it has been suggested that dengue virus replication is regulated by Dnmt2-mediated DNA methylation. However, recent studies have shown that Dnmt2 is a tRNA methyltransferase and that Dnmt2-dependent methylomes lack defined DNA methylation patterns, thus necessitating a systematic re-evaluation of the mosquito genome methylation status. We have now searched the Ae. aegypti genome for candidate DNA modification enzymes. This failed to reveal any known (cytosine-5) DNA methyltransferases, but identified homologues for the Dnmt2 tRNA methyltransferase, the Mettl4 (…

Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus.

2005

Abstract Background: Tacrolimus is metabolized predominantly to 13-O-demethyltacrolimus in the liver and intestine by cytochrome P450 3A (CYP3A). Patients with high concentrations of CYP3A5, a CYP3A isoenzyme polymorphically produced in these organs, require higher doses of tacrolimus, but the exact mechanism of this association is unknown. Methods: cDNA-expressed CYP3A enzymes and a bank of human liver microsomes with known CYP3A4 and CYP3A5 content were used to investigate the contribution of CYP3A5 to the metabolism of tacrolimus to 13-O-demethyltacrolimus as quantified by liquid chromatography–tandem mass spectrometry. Results: Demethylation of tacrolimus to 13-O-demethyltacrolimus was …

Role of Negative Pressure Therapy as Damage Control in Soft Tissue Reconstruction for Open Tibial Fractures.

2017

AbstractThe concept of damage control orthopaedics (DCO) is a strategy that focuses on managing orthopaedic injuries in polytrauma patients who are in an unstable physiological state. The concept of DCO is an extension of damage control surgery or damage limitation surgery (DCS/DLS). Recently, it has become clear that certain patients, following extensive soft tissue trauma, could benefit from the idea of DCS. In the management of severe lower extremity trauma with exposed fracture sites, aggressive early wound excision debridement, early internal fixation, and vascularized wound coverage within a few days after trauma were proposed. A negative-pressure dressing can be easily and rapidly ap…

Identification of Explanatory Variables in Possession of the Ball in High-Performance Women’s Football

2021

[Abstrac] Women’s football is a phenomenon that is experiencing an unstoppable increase in recent years. The objective of this study was to analyze how ball possessions are performed in highperformance women’s football. For this, the 52 matches played by all the national teams participating in the Women’s World Cup 2015 were analyzed. A total of 3740 ball possessions were examined. Using the “move outcome” variable as a reference criterion, a statistically significant relationship was found between possessions that ended in success and possessions that have failed. Specifically, the successful possessions were those that were made in the offensive zone, with a clear intention to progress to…

Identificación de nuevos biomarcadores periféricos de deterioro cognitivo leve y enfermedad de Alhzeimer

2017

NTRODUCCIÓN • Epidemiología de la Enfermedad de Alzheimer. El aumento de la esperanza de vida, debido en parte a los avances en este último siglo de la medicina moderna, da como resultado una mayor población de adultos mayores en nuestra sociedad. Junto a este aumento de la esperanza de vida, han aparecido enfermedades asociadas al envejecimiento, de entre las cuales destacan las demencias. Las demencias son las principales causas de dependencia, incapacidad y muerte en los adultos mayores (Reitz 2011, Cornutiu 2015). De hecho, la Enfermedad de Alzheimer (EA) es la sexta causa de muerte en Estados Unidos según la Alzheimer’s Association (2009). El término demencia describe un síndrome clíni…