Search results for "Dengue fever"
showing 9 items of 19 documents
2015
ABSTRACT Dengue fever is a severe, widespread, and neglected disease with more than 2 million diagnosed infections per year. The dengue virus NS2B/NS3 protease (PR) represents a prime target for rational drug design. At the moment, there are no clinical PR inhibitors (PIs) available. We have identified diaryl (thio)ethers as candidates for a novel class of PIs. Here, we report the selective and noncompetitive inhibition of the serotype 2 and 3 dengue virus PR in vitro and in cells by benzothiazole derivatives exhibiting 50% inhibitory concentrations (IC 50 s) in the low-micromolar range. Inhibition of replication of DENV serotypes 1 to 3 was specific, since all substances influenced neither…
An epigenetic ‘extreme makeover’: the methylation of flaviviral RNA (and beyond)
2020
Beyond their high clinical relevance worldwide, flaviviruses (comprising dengue and Zika viruses) are of particular interest to understand the spatiotemporal control of RNA metabolism. Indeed, their positive single-stranded viral RNA genome (vRNA) undergoes in the cytoplasm replication, translation and encapsidation, three steps of the flavivirus life cycle that are coordinated through a fine-tuned equilibrium. Over the last years, RNA methylation has emerged as a powerful mechanism to regulate messenger RNA metabolism at the posttranscriptional level. Not surprisingly, flaviviruses exploit RNA epigenetic strategies to control crucial steps of their replication cycle as well as to evade sen…
Spatio-Temporal Modeling of Zika and Dengue Infections within Colombia
2018
The aim of this study is to estimate the parallel relative risk of Zika virus disease (ZVD) and dengue using spatio-temporal interaction effects models for one department and one city of Colombia during the 2015&ndash
Louseborne relapsing fever in young migrants, sicily, Italy, july-september 2015
2016
To the Editor: During the early 20th century, at the end of World War I, and during World War II, louseborne relapsing fever (LBRF) caused by Borrelia recurrentis was a major public health problem, especially in eastern Europe and northern Africa (1,2). Currently, poor living conditions, famine, war, and refugee camps are major risk factors for epidemics of LBRF in resource-poor countries, such as those in the Horn of Africa (3,4). Increased migration from resource-poor countries and war/violence create new routes for spread of vectorborne diseases. Recently, several cases of LBRF have been reported among asylum seekers from Eritrea in the Netherlands, Switzerland, and Germany (5–8). All of…
Editorial: Emerging Zoonoses: Eco-Epidemiology, Involved Mechanisms, and Public Health Implications
2015
Zoonoses are currently considered as one of the most important threats for Public Health worldwide. Zoonoses can be defined as any disease or infection that is naturally transmissible from vertebrate or invertebrate animals to humans and vice-versa. Approximately, 75% of recently emerging infectious diseases affecting humans are diseases of animal origin; approximately, 60% of all human pathogens are zoonotic. All types of potential pathogenic agents, including viruses, parasites, bacteria, and fungi, can cause these zoonotic infections. From the wide range of potential vectors of zoonoses, arthropods are probably those of major significance due to their abundance, high plasticity, adaptabi…
Multiple Linear Regression to predict larvicidal activity against <em>Aedes aegypti </em>mosquito
2017
Vector-borne diseases are one of the important health problems in most tropical countries. Aedes aegypti is an important vector for transmission of dengue, yellow fever, chikungunya, arthritis, and Zika fever. According to the World Health Organization, it is estimated that Ae. aegypti causes 50 million infections and 25,000 deaths per year. The emerging scenario highlights that the eco-friendly and effective control measures for mosquito vectors is of crucial importance. One of the most effective vector control measures has been the use of larvicidal compounds however; this success was short lived due to development of resistance against them in many mosquito strains, ecological imbalance …
El TRATAMIENTO PERIODÍSTICO DE LAS NOTICIAS RELACIONADAS CON LOS VIRUS DEL DENGUE Y ZIKA EN LOS MEDIOS DIGITALES DE HONDURAS (2010-2017)
2019
Resumen: En 1979, se identificó la primera epidemia de dengue en Honduras. En 2010, las autoridades sanitarias y gubernamentales hondureñas decretaron lo que sería la quinta epidemia que afectaba a la población. Cinco años más tarde, una enfermedad emergente llegó al continente americano: el zika. Las entidades internacionales como la Organización Mundial de la Salud y la Organización Panamericana de Salud extendieron la alerta a nivel latinoamericano, en especial a los países propensos por su situación geográfica, climatológica y situación socioeconómica. El objetivo del presente estudio es analizar el contenido de las noticias que se publicaron sobre los virus del dengue y zika en tres di…
Assessing the case of Dengue in Argentina 2009: discrimination and fear
2010
After almost a decade, the re-appearance of Dengue in Argentina caused panic and fears. Unlike Bolivia, Brazil and Paraguay where policies of preventions have been followed, the future of dengue is uncertain for Argentina; this paper does not have any political affiliation but emphasizes the role that mass media play in the coverage of epidemics. The question as to whether a newspaper or mass media corporation should maintain a minimum of objectivity is too complex to be resolved in this short article. However, we have so far set forth a model which will help other researchers to interpret topics of this nature in the future. In moments of disorder, uncertainty or disaster, societies experi…
Prevalence of ulcerative stomatitis in arbovirus infections in a Brazilian Northeast population
2020
Background Although there are no population-based studies that support an association, there are reports in the literature of mucocutaneous, vesiculobullous and ulcerated lesions in the oral mucosa in cases of arbovirus infection. The aim of this study is to analyze the prevalence of ulcerative stomatitis in individuals affected by arboviruses in a population of the municipality of Arcoverde, Pernambuco, Brazil. Material and Methods 1,003 people living in an area assigned to a Primary Health Care Unit were interviewed. A structured questionnaire was used for data collection, with questions about sociodemographic variables, residence conditions, general health information, as well as informa…