Search results for "Dependence"

Multi-isotopic and trace element evidence against different formation pathways for oyster microstructures

2021

Geochimica et cosmochimica acta 308, 326-352 (2021). doi:10.1016/j.gca.2021.06.012

A semi-parametric stochastic generator for bivariate extreme events

2017

The analysis of multiple extreme values aims to describe the stochastic behaviour of observations in the joint upper tail of a distribution function. For instance, being able to simulate multivariate extreme events is convenient for end users who need a large number of random replications of extremes as input of a given complex system to test its sensitivity. The simulation of multivariate extremes is often based on the assumption that the dependence structure, the so-called extremal dependence function, is described by a specific parametric model. We propose a simulation method for sampling bivariate extremes, under the assumption that the extremal dependence function is semiparametric. Th…

Glucose regulation and physical performance among older people: the Helsinki Birth Cohort Study

2018

Aims To assess whether disturbances in glucose regulation are associated with impairment in physical performance during a 10-year follow-up. Methods 475 Men and 603 women from the Helsinki Birth Cohort Study were studied. Glucose regulation was evaluated with a 2-h 75-g oral glucose tolerance test (OGTT) in 2001-2004. Subjects were categorised as having either impaired fasting glucose (IFG), impaired glucose tolerance (IGT), newly diagnosed diabetes or previously known diabetes. Physical performance was assessed approximately 10 years later using the validated senior fitness test (SFT). The relationship between glucose regulation and the overall SFT score was estimated using multiple linear…

New Measurements of the Beam Normal Spin Asymmetries at Large Backward Angles with Hydrogen and Deuterium Targets

2017

International audience; New measurements of the beam normal single spin asymmetry in the electron elastic and quasielastic scattering on the proton and deuteron, respectively, at large backward angles and at ⟨Q2⟩=0.22  (GeV/c)2 and ⟨Q2⟩=0.35  ( GeV/c)2 are reported. The experimentally observed asymmetries are compared with the theoretical calculation of Pasquini and Vanderhaeghen [Phys. Rev. C 70, 045206 (2004).PRVCAN0556-281310.1103/PhysRevC.70.045206]. The agreement of the measurements with the theoretical calculations shows a dominance of the inelastic intermediate excited states of the nucleon, πN and the Δ resonance. The measurements explore a new, important parameter region of the exc…

Supervision by the state prerogatives of french sports federations

2013

French sports federations have developed without any state intervention. They had their own prerogatives to organize competitions in their respective sporting discipline. By virtue of their association status, they were entirely governed by private law. However, following a decision taken in 1974 by the Board of State confirming the existence of a public service delegated to the federal structure, the legislation gradually devote the principle of granting their prerogatives by the Ministry of Sports through two acts: the ministerial approval and delegation of public service. Since the issuance of these acts is synonymous powers recognized federations by state law and that the delegation lea…

No association of alcohol dependence with a NMDA-receptor 2B gene variant

2003

Time-dependent asymmetric traveling salesman problem with time windows: Properties and an exact algorithm

2019

Abstract In this paper, we deal with the Time-Dependent Asymmetric Traveling Salesman Problem with Time Windows. First, we prove that under special conditions the problem can be solved as an Asymmetric Traveling Salesman Problem with Time Windows, with suitable-defined time windows and (constant) travel times. Second, we show that, if the special conditions do not hold, the time-independent optimal solution provides both a lower bound and (eventually) an upper bound with a worst-case guarantee for the Time-Dependent Asymmetric Traveling Salesman Problem with Time Windows. Finally, a branch-and-bound algorithm is presented and tested on a set of 4800 instances. The results have been compared…

Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer

2009

We examine the possible evidence that the phytochemical curcumin may overcome resistance to hormonal and cytotoxic agents in breast cancer. We present our observations on MCF-7R, a multidrug-resistant (MDR) variant of the MCF-7 breast cancer cell line. In contrast to MCF-7, MCF-7R lacks aromatase and estrogen receptor alpha (ERalpha) and overexpresses the multidrug transporter ABCB1 and the products of different genes implicated in cell proliferation and survival, like c-IAP-1, NAIP, survivin, and COX-2. Nevertheless, in cytotoxicity and cell death induction assays, we found that the antitumor activity of curcumin is substantial both in MCF-7 and in MCF-7R. We elaborated the diketone system…

Barrier effects on the spatial distribution of Xylella fastidiosa in Alicante, Spain

2021

AbstractSpatial models often assume isotropy and stationarity, implying that spatial dependence is direction invariant and uniform throughout the study area. However, these assumptions are violated when dispersal barriers are present in the form of geographical features or disease control interventions. Despite this, the issue of non-stationarity has been little explored in the context of plant health. The objective of this study was to evaluate the influence of different barriers in the distribution of the quarantine plant pathogenic bacterium Xylella fastidiosa in the demarcated area in Alicante, Spain. Occurrence data from the official surveys in 2018 were analyzed with four spatial Baye…

Defining substance use disorders: do we really need more than heavy use?

2013

Aims: The aim of the study was to explore whether the concept of heavy substance use over time can be used as definition of substance use disorder. Methods: Narrative review. Results: Heavy use over time clearly underlies the neurobiological changes asso- ciated with current thinking of substance use disorders. In addition, there is evidence that heavy use over time can explain the majority of social problems and of burden of disease (morbidity and mortality). A definition of substance use disorders via heavy use over time would avoid some of the problems of current conceptualizations, for instance the cultural specificity of concepts such as loss of control. Finally, stressing the continuu…