Search results for "Depression"

Psychometric properties of the Finnish version of the Young Person's Clinical Outcomes in Routine Evaluation (YP-CORE) questionnaire.

2017

An increasing need exists for suitable measures to evaluate treatment outcome in adolescents. YP-CORE is a pan-theoretical brief questionnaire developed for this purpose, but it lacks studies in different cultures or languages.To explore the acceptability, factor structure, reliability, validity, and sensitivity to change of the Finnish translation of YP-CORE.The study was conducted at the Department of Adolescent Psychiatry, Helsinki University Central Hospital. A Finnish translation was prepared by a team of professionals and adolescents. A clinical sample of 104 patients was asked to complete the form together with BDI-21 and BAI, and 92 of them filled the forms again after a 3-month tre…

Effects of the Best Possible Self intervention: A systematic review and meta-analysis

2019

The Best Possible Self (BPS) exercise promotes a positive view of oneself in the best possible future, after working hard towards it. Since the first work that attempted to examine the benefits of this intervention in 2001, studies on the BPS have grown exponentially and, currently, this is one of the most widely used Positive Psychology Interventions. However, little is yet known about its overall effectiveness in increasing wellbeing outcomes. Thus, the aim of this meta-analysis is to shed light on this question. A systematic literature search was conducted, and 29 studies (in 26 articles) met the inclusion criteria of empirically testing the intervention and comparing it to a control con…

Marte Meo as a port of entry to parental sensitivity - a three–case study

2019

Abstract Background Early parent- child relations play an important role in children’s development. Therapeutic intervention towards infants and toddlers at high-risk intends to prevent mental health problems. In this work, the parent-child-dyad is crucial. The video interaction guidance method, Marte Meo, is one among different methods used in attachment-based treatment in an outpatient infant mental health clinic. Parental sensitivity towards infants and toddlers needs is considered significant in developing secure attachment. Secure attachment is further considered decisive for mental health and the extent to which children are at risk of developing mental health problems. Different trea…

Telomeres in the Brain Cortex of Patients with Major Depressive Disorder

2014

Telomeres are complex structures formed by the end of the DNA molecule at the tip of each chromosomal arm. The repeated (TTAGGG) telomeric sequence progressively shortens during lifespan because it cannot be replicated as somatic cells divide, and is highly susceptible to breakage by free radicals. Critically shortened telomeres activate the genetic program of cell senescence and/or apoptosis. The telomere length measured in peripheral blood leucocytes is considered a reliable marker of biological age, mortality risk and exposure to various pathological conditions, including cardiovascular disease, dementia, and metabolic syndrome. Telomere erosion has been observed in psychiatric disorders…

Central Serotonin2C Receptor: From Physiology to Pathology

2006

Since the 1950s, when serotonin (5-HT) was discovered in the mammalian central nervous system (CNS), an enormous amount of experimental evidence has revealed the pivotal role of this biogenic amine in a number of cognitive and behavioural functions. Although 5-HT is synthesized by a small group of neurons within the raphe nuclei of the brain stem, almost all parts of the CNS receive serotonergic projections. Furthermore, the importance of 5-HT modulation and the fine-tuning of its action is underlined by the large number of 5-HT binding sites found in the CNS. Hitherto, up to 15 different 5-HT receptors subtypes have been identified. This review was undertaken to summarize the work that has…

Endotoxaemia resulting from decreased serotonin tranporter (5-HTT) function: A reciprocal risk factor for depression and insulin resistance?

2015

International audience; Depression and diabetes are serious diseases with an increasing global prevalence. Intriguingly, recent meta-analyses have highlighted an asymmetrical relationship between the two conditions as depressed patients were found to display a higher risk of developing type 2 diabetes than those individuals suffering from diabetes are to become depressed. Based on recent findings, we favor a hypothesis where by decreased peripheral serotonin (5-HT) transporter (5-HTT) function is a reciprocal risk factor for the comorbidity of depression and diabetes, as it can trigger inflammatory pathogenetic mechanisms of both conditions. Higher intestinal levels of 5-HT and 5-HT3 recept…

P-491 - Sensitivity to changes during antidepressant treatment: a comparison of unidimensional depression rating scales in patients with minor depres…

2012

In the efficacy evaluation of antidepressant treatments the total score of the Hamilton Depression Rating Scale (HAMD) is still regarded as the’gold standard’. Studies suggest that unidimensional subscales of the HAMD, which capture the core depressive symptoms, outperform the full HAMD regarding the detection of antidepressant treatment effects. The present study compared several unidimensional subscales of the HAMD and the Inventory of Depressive Symptomatology (IDS) regarding their sensitivity to changes in depression symptoms in a sample of patients with minor depression (MIND). Biweekly IDS-C28 and HAMD17 data from 287 patients of a 10-week randomised, placebo-controlled trial comparin…

The Messinian Salinity Crisis deposits in the Balearic Promontory: An undeformed analog of the MSC Sicilian basins??

2021

International audience; The Messinian Salinity Crisis (MSC) is a controversial geological event that influenced the Mediterranean Basin in the late Miocene leaving behind a widespread Salt Giant. Today, more than 90% of the Messinian evaporitic deposits are located offshore, buried below the Plio-Quaternary sediments and have thus been studied mainly by marine seismic reflection imaging. Onshore-offshore records’ comparisons and correlations should be considered a key approach to progress in our understanding of the MSC.This approach has however not been widely explored so far. Indeed, because of the erosion on the Messinian continental shelves and slopes during the MSC, only few places in …

“L’intrusione marina negli acquiferi carbonatici costieri della Sicilia Sud-Orientale”

2007

RUOLO DELL’ESERCIZIO FISICO NELLA QUALITÀ DI VITA DI SOGGETTI CON SCLEROSI MULTIPLA. ROLE OF EXERCISE IN THE QUALITY OF LIFE IN SUBJECTS WITH MULTIPL…

2012

La sclerosi multipla è una patologia neurodegenerativa cronica che ha un impatto considerevole sullo stato fisico, psicologico e sociale dei pazienti, influenzando negativamente la loro qualità di vita. Tra i fattori contribuenti ad una ridotta qualità di vita sono inclusi la presenza di dolore, spasmi, sindromi depressive, l’aumento della fatica e la riduzione della forza muscolare, mobilità ed autonomia nella deambulazione. Accanto alla medicina convenzionale, varie forme di medicina complementare ed alternativa, tra cui l’esercizio fisico, sono utilizzate dai soggetti con sclerosi multipla. Tuttavia, poche sono le prove scientifiche a sostegno della loro efficacia nel ridurre i sintomi d…