Search results for "Deriva"
showing 10 items of 1423 documents
Stieltjes Differential Inclusions with Periodic Boundary Conditions without Upper Semicontinuity
2021
We are studying first order differential inclusions with periodic boundary conditions where the Stieltjes derivative with respect to a left-continuous non-decreasing function replaces the classical derivative. The involved set-valued mapping is not assumed to have compact and convex values, nor to be upper semicontinuous concerning the second argument everywhere, as in other related works. A condition involving the contingent derivative relative to the non-decreasing function (recently introduced and applied to initial value problems by R.L. Pouso, I.M. Marquez Albes, and J. Rodriguez-Lopez) is imposed on the set where the upper semicontinuity and the assumption to have compact convex value…
Crystal structures of allyltriphenyl-phosphonium halogenocuprates(I)
2013
Alternating-current electrochemical synthesis is used to obtain for the first time halogenocuprates of an allyl derivative of phosphonium of the composition (CH2=CHCH2(C6H5)3P)CuX2 (X = Br (I), Cl (II)). Compound I crystallizes in the space group P21, a = 9.6341(3) A, b = 12.4167(4) A, c = 9.9618(4) A, β = 117.484(5)°, Z = 2. Compound II crystallizes in the space group P21/n, a = 9.9725(5) A, b = 15.4586(8) A, c = 13.7557(5) A, β = 90.429(4)°, Z = 4. In the structures of I and II quasilinear CuX 2 − anions are held by C-H…X hydrogen bonds inside a framework formed by the stacking of phenyl groups from CH2=CHCH2(C6P5)3P+ cations. Allyl groups are not involved in coordination with copper(I) a…
Carbohydrate-Based Nanocarriers Exhibiting Specific Cell Targeting with Minimum Influence from the Protein Corona.
2015
Whenever nanoparticles encounter biological fluids like blood, proteins adsorb on their surface and form a so-called protein corona. Although its importance is widely accepted, information on the influence of surface functionalization of nanocarriers on the protein corona is still sparse, especially concerning how the functionalization of PEGylated nanocarriers with targeting agents will affect protein corona formation and how the protein corona may in turn influence the targeting effect. Herein, hydroxyethyl starch nanocarriers (HES-NCs) were prepared, PEGylated, and modified on the outer PEG layer with mannose to target dendritic cells (DCs). Their interaction with human plasma was then s…
Magnetic transition metal complexes of tetrathiafulvalene (TTF) derivatives
1997
We have prepared and characterized the transition metal complexes of two different TTF derivatives. We have oxidized the different complexes with electrooxidation and chemical oxidation techniques and the results are discussed. The magnetic properties of the complexes have been studied. TTF-carboxylate chelates are not stable enough, but thioether-TTF shows promising charge transfer salts.
In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs
2019
Beagle dog is a standard animal model for evaluating nonclinical pharmacokinetics of new drug candidates. Glucuronidation in intestine and liver is an important first-pass drug metabolic pathway, especially for phenolic compounds. This study evaluated the glucuronidation characteristics of several 7-hydroxycoumarin derivatives in beagle dog's intestine and liver in vitro. To this end, glucuronidation rates of 7-hydroxycoumarin (compound 1), 7-hydroxy-4-trifluoromethylcoumarin (2), 6-methoxy-7-hydroxycoumarin (3), 7-hydroxy-3-(4-tolyl)coumarin (4), 3-(4-fluorophenyl)coumarin (5), 7-hydroxy-3-(4-hydroxyphenyl)coumarin (6), 7-hydroxy-3-(4-methoxyphenyl)coumarin (7), and 7-hydroxy-3-(1H-1,2,4-t…
A cocrystal of two Mo(VI) complexes bearing different diastereomers of the 2,4-di-tert-butyl-6-{[(1-oxido-1-phenylpropan-2-yl)(methyl)amino]methyl}ph…
2013
The title cocrystal contains two chiral conformational diastereomers, viz. (1S,2R,RN)- and (1S,2R,SN)-, of [2,4-ditert-butyl-6-{[(1-oxido-1-phenylpropan-2-yl)(methyl)amino]- methyl}phenolato](methanol)-cis-dioxidomolybdenum(VI), [Mo(C25H35NO2)O2(CH3OH)], representing the first example of a structurally characterized molybdenum complex with enantiomerically pure ephedrine derivative ligands. The MoVI cations exhibit differently distorted octahedral coordination environments, with two oxide ligands positioned cis to each other. The remainder of the coordination comprises phenoxide, alkoxide and methanol O atoms, with an amine N atom completing the octahedron. The distinct complexes are linked…
Hyperreaaliluvut
2017
Hyperreaaliluvut ovat reaalilukujen joukon laajennus, jossa on olemassa äärettömän pieniä ja suuria lukuja. Hyperreaalilukuja käytetään differentiaali- ja integraalilaskennassa. Metodi on suosittu erityisesti fyysikoiden keskuudessa. Analyysin osa-aluetta, jossa hyödynnetään hyperreaalilukuja, kutsutaan epästandardiksi analyysiksi. Epästandardissa analyysissä käytetään analyysille epästandardeja työkaluja, josta nimi juontuu. Hyperreaalilukujen edut verrattaessa reaalilukuihin tulevat esille epästandardissa analyysissä. Varsinkin fysiikassa hyödynnetään yhtälöiden differentiaalimuotoja ja integroinnissa lähtökohtana pidetään infinitesimaalin valintaa. Tutkielmassa hyperreaaliluvut määritell…
Análisis de la introducción del protocolo de ahorro de sangre de cirugía cardíaca en un hospital terciario
2018
Antecedentes: En la última década, todos los sistemas de salud avanzados están implantando programas de ahorro de sangre siguiendo las recomendaciones de Sociedades Europeas y Americanas que han propuesto guías clínicas para el ahorro de sangre, siguiendo un enfoque multidisciplinar y multimodal. La reducción en el consumo lleva emparejado una reducción de complicaciones asociadas a la transfusión, mejora de resultados clínicos y reducción de costes. La cirugía cardiaca es una de las especialidades quirúrgicas con mayor riesgo hemorrágico, tanto por la intervención quirúrgica en sí misma, como por la influencia farmacológica a la cual se ve sometido el paciente en el periodo perioperatorio.…
El papel del ejercicio físico en la inducción de BDNF y sus vías de señalización en el sistema nervioso central. Aplicación neurobiológica en modelos…
2014
La actividad física previene numerosas patologías y mejora muchos rasgos fisiopatológicos en diferentes enfermedades. El ejercicio ha sido asociado clásicamente con beneficios en desórdenes musculares y metabólicos. Sin embargo, los efectos del ejercicio en la función cerebral, especialidad conocida como “Neurobiología del ejercicio”, han cobrado gran importancia en los últimos años. Los efectos beneficiosos del ejercicio físico han sido establecidos en muchas enfermedades tales como la enfermedad de Alzheimer, el Parkinson, la esclerosis lateral amiotrófica, la esquizofrenia, el trastorno bipolar y los trastornos depresivos, entre otros. Estos hallazgos han llevado a utilizar el ejercicio …
Finanšu derivatīvu instrumentu vērtēšana 2008. un 2012. gada finanšu krīzē
2016
Mūsdienās pastāvoša problēma finanšu tirgos ir spēja precīzi novērtēt finanšu derivatīvus, ņemot vērā to sarežģīto uzbūvi. Turklāt tieši krīzes periodos, kādi bija 2008.gada trešais ceturksnis un 2010.-2012.gads, šīs prasmes ir īpaši nozīmīgas, lai papildus nepaaugstinātu finanšu risku. Darba mērķis ir izpētīt Forward cenas, Black-Scholes-Merton un Binomiālā opciju novērtēšanas modeļu spēju novērtēt finanšu derivatīvus krīzes periodā un tajā pašā laikā tirgus cenu neatbilstību modeļiem tirgū pastāvošās panikas dēļ. Darbā izvirzītās hipotēzes tiek apstiprinātas; un, pieaugot finanšu derivatīva termiņam, modeļu precizitāte krītas. Darbā tiek sniegti ieteikumi samazināt finanšu derivatīvu tirg…