Search results for "Derivative"
showing 10 items of 1074 documents
Flapless application of enamel matrix derivative in periodontal retreatment: A multicentre randomized feasibility trial
2021
AIM To investigate the potential benefit of enamel matrix derivative (EMD) as adjunct to re-instrumentation of residual pockets persisting after steps 1 and 2 of periodontal therapy. MATERIAL AND METHODS 44 adult patients participated in a multicentre feasibility randomized clinical trial with split-mouth design. They had presented at re-evaluation after initial non-surgical periodontal therapy (steps 1 and 2 of periodontal therapy) for generalized periodontitis with at least 2 teeth with residual probing pocket depths (PPD) ≥5 and ≤8 mm, with bleeding on probing (BOP). Two teeth with similar PPD were randomized to receive re-instrumentation either with (test) or without (control) adjunctiv…
Subepithelial connective tissue graft with or without enamel matrix derivative for the treatment of Miller class I and II gingival recessions: a cont…
2012
Background The aim of this study was to evaluate whether the combination of enamel matrix derivative (EMD) with subepithelial connective tissue graft (SCTG) plus coronally advanced flap (CAF) would improve the treatment outcomes of Miller class I and II gingival recessions when compared with the same technique (SCTG plus CAF) alone. Methods The study was designed as a randomized, parallel, controlled, double-blinded clinical trial. Forty-two patients were randomly assigned in the test group (SCTG plus EMD) and in the control group (SCTG). Patients had at least one gingival recession ≥ 2 mm. The clinical parameters were evaluated at baseline and at 14 d, 1, 3, 6 and 12 mo follow-up time poin…
Synthesis and Characterization of a Novel Series of Agonist Compounds as Potential Radiopharmaceuticals for Imaging Dopamine D-2/3 Receptors in Their…
2014
Imaging of dopamine D2/3 receptors (D2/3R) can shed light on the nature of several neuropsychiatric disorders in which dysregulation of D2/3R signaling is involved. Agonist D2/3 tracers for PET/SPECT imaging are considered to be superior to antagonists because they are more sensitive to dopamine concentrations and may selectively label the high-affinity receptor state. Carbon-11-labeled D2/3R agonists have been developed, but these short-lived tracers can be used only in centers with a cyclotron. Here, we report the development of a series of novel D2R agonist compounds based on the 2-aminomethylchromane (AMC) scaffold that provides ample opportunities for the introduction of longer-lived […
Synthesis of 2-Prenylated Alkoxylated Benzopyrans by Horner–Wadsworth–Emmons Olefination with PPARα/γ Agonist Activity
2021
[Image: see text] We have synthesized series of 2-prenylated benzopyrans as analogues of the natural polycerasoidol, a dual PPARα/γ agonist with anti-inflammatory effects. The prenylated side chain consists of five or nine carbons with an α-alkoxy-α,β-unsaturated ester moiety. Prenylation was introduced via the Grignard reaction, followed by Johnson–Claisen rearrangement, and the α-alkoxy-α,β-unsaturated ester moiety was introduced by the Horner–Wadsworth–Emmons reaction. Synthetic derivatives showed high efficacy to activate both hPPARα and hPPARγ as dual PPARα/γ agonists. These prenylated benzopyrans emerge as lead compounds potentially useful for preventing cardiometabolic diseases.
AN EXTENDED KALMAN FILTER BASED TECHNIQUE FOR ON-LINE IDENTIFICATION OF UAS PARAMETERS.
2015
The present article deals with the identification,at the same time, of aircraft stability and control parameters taking into account dynamic damping derivatives. Such derivatives,due to the rate of change of the angle of attack, are usually neglected. So the damping characteristics of aircraft dynamics are attributed only on pitch rate derivatives. To cope with the dynamic effects of these derivatives, authors developed devoted procedures to estimate them. In the present paper, a complete model of aerodynamic coefficients has been tuned-up to identify simultaneously the whole set of derivatives. Besides, in spite of the employed reduced order model and/or decoupled dynamics, a six degrees o…
An Extended Kalman Filter-Based Technique for On-Line Identification of Unmanned Aerial System Parameters
2015
ABSTRACT: The present article deals with the identification, at the same time, of aircraft stability and control parameters taking into account dynamic damping derivatives. Such derivatives, due to the rate of change of the angle of attack, are usually neglected. So the damping characteristics of aircraft dynamics are attributed only on pitch rate derivatives. To cope with the dynamic effects of these derivatives, authors developed devoted procedures to estimate them. In the present paper, a complete model of aerodynamic coefficients has been tuned-up to identify simultaneously the whole set of derivatives. Besides, in spite of the employed reduced order model and/or decoupled dynamics, a s…
Synthesis, characterization of diorganotin(IV) complexes of N-(2-hydroxyarylidene)aminoacetic acid and antitumour screening in vivo in ehrlich ascite…
2001
Some new diorganotin(IV) complexes have been prepared by reacting potassium N-(2-hydroxyarylidene)aminoacetate with R2SnCl2(R = Me,nBu,Ph). The complexes have been characterized by 1H,13C,119Sn NMR, IR and 119mSn Mössbauer spectroscopic techniques in combination with elemental analysis. In the solid state, the complexes possess penta- and hexa-coordinated tin centres. The hexa-coordinated tin complexes were found to dissociate in solution, giving rise to penta-coordinated species as revealed by 119Sn NMR spectroscopy. Antitumour screening in vivo of the complexes L4snPh2,L4SnPh2· Ph3SnCl and L4SntBU2·t Bu2SnCl2 (L4 = N-(2-hydroxyacetophenone)aminoacetate) is also reported. Copyright © 2001 …
On the critical behavior for time-fractional pseudo-parabolic type equations with combined nonlinearities
2022
AbstractWe are concerned with the existence and nonexistence of global weak solutions for a certain class of time-fractional inhomogeneous pseudo-parabolic-type equations involving a nonlinearity of the form $|u|^{p}+\iota |\nabla u|^{q}$ | u | p + ι | ∇ u | q , where $p,q>1$ p , q > 1 , and $\iota \geq 0$ ι ≥ 0 is a constant. The cases $\iota =0$ ι = 0 and $\iota >0$ ι > 0 are discussed separately. For each case, the critical exponent in the Fujita sense is obtained. We point out two interesting phenomena. First, the obtained critical exponents are independent of the fractional orders of the time derivative. Secondly, in the case $\iota >0$ ι > 0 , we show that the gradie…
Functional Derivative Approach
2001
Let us now leave the path integral formalism temporarily and reformulate operatorial quantum mechanics in a way which will make it easy later on to establish the formal connection between operator and path integral formalism. Our objective is to introduce the generating functional into quantum mechanics. Naturally we want to generate transition amplitudes. The problem confronting us is how to transcribe operator quantum mechanics as expressed in Heisenberg’s equation of motion into a theory formulated solely in terms of c-numbers. This can be achieved either by Schwinger’s action principle or with the aid of a generation functional defined as follows:
Initial Data for Non-Linear Evolution Equations and Differentiable Vectors of Group Representations
1995
Regularity properties of non-linear Lie algebra representations are defined. These properties are satisfied in examples given by evolution equations. We prove that this regularity implies that the set of C ∞ vectors for the non-linear group representation obtained by integration of the Lie algebra representation coincide with the set of C ∞ vectors of the linear part (the order one term) of this group representation.