Search results for "Design"
showing 10 items of 5885 documents
Pseudomonas corrugata crpCDE is part of the cyclic lipopeptide corpeptin biosynthetic gene cluster and is involved in bacterial virulence in tomato a…
2014
Summary: Pseudomonas corrugataCFBP 5454 produces two kinds of cyclic lipopeptides (CLPs), cormycin A and corpeptins, both of which possess surfactant, antimicrobial and phytotoxic activities. In this study, we identified genes coding for a putative non-ribosomal peptide synthetase and an ABC-type transport system involved in corpeptin production. These genes belong to the same transcriptional unit, designated crpCDE. The genetic organization of this locus is highly similar to other PseudomonasCLP biosynthetic clusters. Matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) analysis revealed that transporter and synthetase genomic knock-out mutants were u…
Connection between optimal control theory and adiabatic-passage techniques in quantum systems
2012
This work explores the relationship between optimal control theory and adiabatic passage techniques in quantum systems. The study is based on a geometric analysis of the Hamiltonian dynamics constructed from the Pontryagin Maximum Principle. In a three-level quantum system, we show that the Stimulated Raman Adiabatic Passage technique can be associated to a peculiar Hamiltonian singularity. One deduces that the adiabatic pulse is solution of the optimal control problem only for a specific cost functional. This analysis is extended to the case of a four-level quantum system.
Ascesa al cièlo
2020
Ascesa al cièlo è il titolo della cartolina progettata in omaggio a Dante Alighieri, in occasione del 700° anniversario della morte del poeta. La cartolina è stata pubblicata sul Corriere della Sera e poi inserita nel libro “Dantedì, visioni contemporanee del poeta” insieme ad altre 24 opere realizzate da professionisti della comunicazione visiva italiani. Il «cièlo» stellato è qui la fonte ispiratrice, declinato con tipografia neoclassica e richiami alla scuola siciliana, fondamentale nella nascita della lingua italiana, così come agli angeli e ai putti con cui Giacomo Serpotta decorò le chiese palermitane tra Seicento e Settecento. Il testo raccoglie i contributi di Paolo Di Stefano, Albe…
Biases in study design, implementation, and data analysis that distort the appraisal of clinical benefit and ESMO-Magnitude of Clinical Benefit Scale…
2021
BACKGROUND: The European Society for Medical Oncology-Magnitude of Clinical Benefit Scale (ESMO-MCBS) is a validated, widely used tool developed to score the clinical benefit from cancer medicines reported in clinical trials. ESMO-MCBS scores assume valid research methodologies and quality trial implementation. Studies incorporating flawed design, implementation, or data analysis may generate outcomes that exaggerate true benefit and are not generalisable. Failure to either indicate or penalise studies with bias undermines the intention and diminishes the integrity of ESMO-MCBS scores. This review aimed to evaluate the adequacy of the ESMO-MCBS to address bias generated by flawed design, im…
Analyzing big datasets of genomic sequences: fast and scalable collection of k-mer statistics
2019
Abstract Background Distributed approaches based on the MapReduce programming paradigm have started to be proposed in the Bioinformatics domain, due to the large amount of data produced by the next-generation sequencing techniques. However, the use of MapReduce and related Big Data technologies and frameworks (e.g., Apache Hadoop and Spark) does not necessarily produce satisfactory results, in terms of both efficiency and effectiveness. We discuss how the development of distributed and Big Data management technologies has affected the analysis of large datasets of biological sequences. Moreover, we show how the choice of different parameter configurations and the careful engineering of the …
New Author Guidelines for Displaying Data and Reporting Data Analysis and Statistical Methods in Experimental Biology
2019
The American Society for Pharmacology and Experimental Therapeutics has revised the Instructions to Authors for Drug Metabolism and Disposition, Journal of Pharmacology and Experimental Therapeutics, and Molecular Pharmacology These revisions relate to data analysis (including statistical analysis) and reporting but do not tell investigators how to design and perform their experiments. Their overall focus is on greater granularity in the description of what has been done and found. Key recommendations include the need to differentiate between preplanned, hypothesis-testing, and exploratory experiments or studies; explanations of whether key elements of study design, such as sample size and …
Acquisition, filtering and toll data processing system for obtaining origin-destination matrix and travel times on highways
2012
This paper presents an acquisition, filtering and real-time toll data processing system that provides a base for resolution and generation of studies and models of behavior on highways. Crossing points estimation, speed calculation, study traffic flow, travel time estimation and stopping points can also be provided. The complexity of processing with supplied data volume makes indispensable a less relevant information filtering. This filtering can be done through indicators such as speed or nullity of fields and a performance improvement job in database level using views, materializations, partitioning and parallelism. A web application called MODA has been developed. This application make e…
Automatic Customization Framework for Efficient Vehicle Routing System Deployment
2017
Vehicle routing systems provide several advantages over manual transportation planning and they are attracting growing attention. However, deployment of these systems can be prohibitively costly, especially for small and medium-sized enterprises: the customization, integration, and migration is laborious and requires operations research expetise. We propose an automated configuration workflow for vehicle routing system and data flow customization, which provides the necessary basis for more experimental work on the subject. Our preliminary results with learning and adaptive algorithms support the assumption of applicability of the proposed configuration framework. The strategies presented h…
Technology-Supported Guidance Models Stimulating the Development of Critical Thinking in Clinical Practice: Protocol for a Mixed Methods Systematic R…
2020
BackgroundCritical thinking is an essential skill that nursing students need to develop. Technological tools have opened new avenues for technology-supported guidance models, but the challenges and facilitators of such guidance models, as well as how they stimulate the development of critical thinking, remain unclear.ObjectiveWe developed a protocol for a mixed methods systematic review to investigate the use of technology-supported guidance models that stimulate the development of critical thinking in nursing education clinical practice.MethodsA convergent integrated design following the Joanna Briggs Institute Manual for Evidence Synthesis will be employed. A pair of authors will select t…
Guiding the modeller: organizing and selecting experimental data for single cell models using the CoCoDat database
2003
Collating, organizing and selecting quantitative experimental data are time-consuming tasks necessary for building and constraining biophysically realistic neuronal models. The CoCoDat (Collation of Cortical Data) database has been designed as an advanced environment for storing, organizing and retrieving detailed, uninterpreted quantitative data on morphology, electrophysiology and connectivity from the published literature according to neurophysiological concepts. All experimental data are linked to exact bibliographical references and detailed records of procedures used in the experiments that produced the data. We demonstrate the usefulness of CoCoDat for implementation of an example mo…