Search results for "Design"
showing 10 items of 5885 documents
Crystal structure of human gamma-butyrobetaine hydroxylase.
2010
Gamma-butyrobetaine hydroxylase (GBBH) is a 2-ketoglutarate-dependent dioxygenase that catalyzes the biosynthesis of l-carnitine by hydroxylation of gamma-butyrobetaine (GBB). l-carnitine is required for the transport of long-chain fatty acids into mitochondria for generating metabolic energy. The only known synthetic inhibitor of GBBH is mildronate (3-(2,2,2-trimethylhydrazinium) propionate dihydrate), which is a non-hydroxylatable analog of GBB. To aid in the discovery of novel GBBH inhibitors by rational drug design, we have solved the three-dimensional structure of recombinant human GBBH at 2.0A resolution. The GBBH monomer consists of a catalytic double-stranded beta-helix (DBSH) domai…
From cars to bikes – the feasibility and effect of using e-bikes, longtail bikes and traditional bikes for transportation among parents of children a…
2017
Abstract Background The present study aims to increase bicycling and level of physical activity (PA), and thereby promote health in parents of toddlers, by giving access to different bicycle types. There is a need for greater understanding of e-bikes and their role in the transportation network, and further effects on PA levels and health. Moreover, longtail bikes could meet certain practical needs not fulfilled by e-bikes or traditional bikes, hence increased knowledge regarding their feasibility should be obtained. No previous studies have investigated whether providing an e-bike or a longtail bike over an extended period in a sample of parents of toddlers influence objectively assessed a…
Power Density Optimization of EMI Filters for Power Electronic Converters
The switching power converters are used in a broad variety of applications, from the consumer electronics to the DC distribution systems, from the vehicle applications (road vehicles, marine vehicles, aircraft) to the industrial automation. In each of these application fields, the conversion systems which present more compact size and reduced weight, at the same power, are strongly required in relation to stringent design constraints. In this context, the optimization of the power density of the converter becomes an essential requirement. The increase of the switching frequency of the static devices allows an improvement of the power density, thanks to the possibility of reducing the sizes …
Impressing my friends: The role of social value in green purchasing attitude for youthful consumers
2021
Abstract Prior studies predominantly use cross-sectional designs to determine effects of pro-environmental beliefs on green purchasing attitudes, thereby limiting the possibility for causal inferences and examining mediation effects. We overcome these gaps by adopting a two-wave longitudinal design to test a moderated-mediation model that draws on consumer choice theory, positing that the effect of implicit pro-environmental beliefs on green purchasing attitudes is mediated by perceived social value from buying green, while the relationship between pro-environmental beliefs and perceived social value is moderated by perceived inconvenience of buying green. Findings from a sample of Polish y…
EXPA, Galleria di Architettura, Grafica e Design
2006
EXPA é l'acronimo di Exhibition Palermo, un esplicito riferimento alla principale attività che si svolge nella galleria, quella espositiva, e alla sua precisa identità territoriale. La Galleria di architettura, grafica e design, é posta lungo la via Alloro nel quartiere storico della Kalsa. La sua collocazione geografica è uno dei fattori determinanti la scelta del caso, in quanto, insieme al complesso delle attività culturali' che vi si svolgono, costituisce i due aspetti non separabili del processo di valorizzazione e di diffusione della cultura del design, che si sviluppa attraverso una sinergia di collaborazioni tra enti pubblici e privati, dipartimenti e facoltà, studenti, laureati, pr…
¿Qué aprenden unos estudiantes en una experiencia formativa de Didáctica de las Ciencias Experimentales en el Grado de Educación Infantil?
2020
Esta investigación pretende conocer si evolucionan los conocimientos iniciales de unas maestras de Educación Infantil en su formación inicial en el ámbito de la didáctica de las ciencias. La experiencia se realizó con estudiantes de 3º del Grado de Educación Infantil, tras trabajar la propuesta “Cómo enseñar el cuerpo humano y los hábitos saludables en Educación Infantil”. Se utilizó un diseño cuantitativo no experimental con pretest y postest. Los resultados ponen de manifiesto los logros conseguidos, pero también revelan, de modo preocupante, las carencias con la que llegan y la insuficiente evolución tras esta primera intervención. Esto supone una llamada de atención para plantearnos qué…
A Survey of Active Learning for Quantifying Vegetation Traits from Terrestrial Earth Observation Data
2021
The current exponential increase of spatiotemporally explicit data streams from satellite-based Earth observation missions offers promising opportunities for global vegetation monitoring. Intelligent sampling through active learning (AL) heuristics provides a pathway for fast inference of essential vegetation variables by means of hybrid retrieval approaches, i.e., machine learning regression algorithms trained by radiative transfer model (RTM) simulations. In this study we summarize AL theory and perform a brief systematic literature survey about AL heuristics used in the context of Earth observation regression problems over terrestrial targets. Across all relevant studies it appeared that…
Seismic behavior of exterior RC beam-column joints without code-specified ties in the joint core
2021
Abstract Beam-column joint design for reinforced concrete (RC) buildings is a critical issue for modern earthquake engineering, because for these structural elements, the current codes provide several geometrical constraints and reinforcement provisions, which may be very complex to implement during the construction phase. To investigate how a construction error might influence the joint behavior, two identical full-scale exterior beam-column joints specimens are built, according to Italian Building Code specifications for the high ductility class, but without the required horizontal ties inside the joint panel. This construction error could be plausible because, according to the design dra…
TERREMOTO E RICOSTRUZIONE: MESSINA 1908, VERSO UNA PROGETTAZIONE “CONSAPEVOLE” : La teoria della maggiore resistenza delle strutture “circolari” e il…
2019
TERREMOTO E RICOSTRUZIONE: MESSINA 1908, VERSO UNA PROGETTAZIONE “CONSAPEVOLE” La teoria della maggiore resistenza delle strutture “circolari” e il contributo della pubblicistica al dibattito sulla costruzione antisismica. Le storie raccontate in questo volume esaminano congiuntamente il duplice sguardo della ricerca sulla progettazione orientata in senso antisismico e sviluppata nell’ambito del dibattito nato a Messina dopo il terremoto del 1908. Se ampie si rivelano le testimonianze di forme di progettazioni “consapevoli”, cioè di accorgimenti che integrano il problema sismico all’interno di convenzioni costruttive di durata secolare, durante le fasi che hanno preceduto le molteplici rico…
Life cycle assessment of roads: Material and process related energy savings
2018
The need for climate change mitigation calls for significant actions to match the sustainable development goals and, in this context, road construction and management play a relevant role (cf. EU Green Public Procurement Criteria for Road Design, Construction and Maintenance and Environmental Product Declarations - EPD). In such a context, the role of the Life Cycle Assessment (LCA) methodology is broadly recognized as a tool to quantify sustainability of processes and systems. This study aims at calculating the life-cycle energy and carbon footprint of a typical Italian urban road, including materials production, transportation, construction, maintenance, and rehabilitation. The LCA approa…