Search results for "Design"

The reporting of study and population characteristics in degenerative cervical myelopathy: A systematic review

2017

OBJECT: Degenerative cervical myelopathy [DCM] is a disabling and increasingly prevalent condition. Variable reporting in interventional trials of study design and sample characteristics limits the interpretation of pooled outcomes. This is pertinent in DCM where baseline characteristics are known to influence outcome. The present study aims to assess the reporting of the study design and baseline characteristics in DCM as the premise for the development of a standardised reporting set. METHODS: A systematic review of MEDLINE and EMBASE databases, registered with PROSPERO (CRD42015025497) was conducted in accordance with PRISMA guidelines. Full text articles in English, with >50 patients (p…

A systematic literature review of participatory design studies involving teachers

2021

Modular organization in the reductive evolution of protein-protein interaction networks

2006

Analysis of the reduction in genome size of Buchnera aphidicola from its common ancestor E. coli shows that the organization of networks into modules is the property that seems to be directly related with the evolutionary process of genome reduction.

Dark Design Patterns : An End-User Perspective

2020

The number of websites and mobile applications available is growing continually, as are the persuasive approaches to influence human behavior and decision making. Although designing for persuasion offers several potential benefits, recent developments expose various deceptive designs, that is, dark patterns, that utilize psychological factors to nudge people toward, from someone else’s perspective, desired directions. This paper contributes to an increased awareness of the phenomenon of dark patterns through our exploring how users perceive and experience these patterns. Hence, we chose a qualitative research approach, with focus groups and interviews, for our exploration. Our analysis show…

Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocyte…

2008

A small series of aminobisphosphonates (N-BPs) structurally related to zoledronic acid was synthesized with the aim of improving activity toward activation of human gammadelta T cells and in turn their in vivo antitumor activity. The absence of the 1-OH moiety, together with the position and the different basicity of the nitrogen, appears crucial for antitumor activity. In comparison to zoledronic acid, compound 6a shows a greater ability to activate gammadelta T cells expression (100 times more) and a proapoptotic effect that is better than zoledronic acid. The potent activation of gammadelta T cells, in addition to evidence of the in vivo antitumor activity of 6a, suggests it may be a new…

Design procedure for prestressed concrete beams

2014

Abstract. The theoretical basis and the main results of a design procedure, which attempts to provide the optimal layout of ordinary reinforcement in prestressed concrete beams, subjected to bending moment and shear force are presented. The difficulties encountered in simulating the actual behaviour of prestressed concrete beam in presence of coupled forces bending moment - shear force are discussed; particular emphasis is put on plastic models and stress fields approaches. A unified model for reinforced and prestressed concrete beams under axial force - bending moment - shear force interaction is provided. This analytical model is validated against both experimental results collected in li…

A Viscoelastic Model for the Long-Term Deflection of Segmental Prestressed Box Girders

2017

Most of segmental prestressed concrete box girders exhibit excessive multidecade deflections unforeseeable by past and current design codes. To investigate such a behavior, mainly caused by creep and shrinkage phenomena, an effective finite element (FE) formulation is presented in this article. This formulation is developed by invoking the stationarity of an energetic principle for linear viscoelastic problems and relies on the Bazant creep constitutive law. A case study representative of segmental prestressed concrete box girders susceptible to creep is also analyzed in the article, that is, the Colle Isarco viaduct. Its FE model, based on the aforementioned energetic formulation, was succ…

A practical methodology to perform global sensitivity analysis for 2D hydrodynamic computationally intensive simulations

2021

Sensitivity analysis is a commonly used technique in hydrological modeling for different purposes, including identifying the influential parameters and ranking them. This paper proposes a simplified sensitivity analysis approach by applying the Taguchi design and the ANOVA technique to 2D hydrodynamic flood simulations, which are computationally intensive. This approach offers an effective and practical way to rank the influencing parameters, quantify the contribution of each parameter to the variability of the outputs, and investigate the possible interaction between the input parameters. A number of 2D flood simulations have been carried out using the proposed combinations by Taguchi (L27…

Optimal Configuration for N-Dimensional Twin Torus Networks

2014

Torus topology is one of the most common topologies used in the current largest supercomputers. Although 3D torus is widely used, recently some supercomputers in the Top500 list have been built using networks with topologies of five or six dimensions. To obtain an nD torus, 2n ports per node are needed. These ports can be offered by a single or several cards per node. In the second case, there are multiple ways of assigning the dimension and direction of the card ports. In a previous work we proposed the 3D Twin (3DT) torus which uses two 4-port cards per node, and obtained the optimal port configuration. This paper extends and generalizes that work in order to obtain the optimal port confi…

Clinical outcomes of patients with diabetes mellitus treated with Absorb bioresorbable vascular scaffolds: a subanalysis of the European Multicentre …

2017

Background Data on the clinical performance of bioresorbable scaffolds in patients with diabetes mellitus (DM) are still limited. The present study reported 1-year clinical outcomes associated with the use of everolimus-eluting bioresorbable vascular scaffolds (Absorb BVS; Abbott Vascular, Santa Clara, CA) in DM patients. Methods and Results This was a subanalysis from the GHOST-EU (Gauging coronary Healing with biOresorbable Scaffolding plaTforms in Europe) multicenter retrospective registry including patients treated with Absorb BVS between November 2011 and September 2014. In this study, a comparative analysis stratified according to DM was performed. The primary endpoint was target lesi…