Search results for "Design"

Theoretical studies of HIV-1 reverse transcriptase inhibition

2012

Computational methods for accurately calculating the binding affinity of a ligand for a protein play a pivotal role in rational drug design. We herein present a theoretical study of the binding of five different ligands to one of the proteins responsible for the human immunodeficiency virus type 1 (HIV-1) cycle replication; the HIV-1 reverse transcriptase (RT). Two types of approaches are used based on molecular dynamics (MD) simulations within hybrid QM/MM potentials: the alchemical free energy perturbation method, FEP, and the pathway method, in which the ligand is physically pulled away from the binding site, thus rendering a potential of mean force (PMF) for the binding process. Our com…

A note about 2-(v,5,lambda) designs

2010

Yo logo(s): On the icono-plastic configuration of brand symbols

2015

Among the various areas with which the vast research field of branding is concerned, brand image is recognized as a territory most pertinently analyzed with semiotic tools, since it is populated by symbols that are amenable to interpretation, such as brand logos. According to Henderson and Cote (1998), logos are graphic designs that companies uses, with or without their name, to identify themselves or their products. Semiotics, and particularly structuralist semiotics (e.g., Floch 1990,1995; Landowski 1989; Fabbri 1998; Marrone 2001, 2007), has largely abandoned the scrutiny of symbols and signs as standalone objects of analysis, in favour of the conditions of meaning that underlie brand na…

Suomalaisten designyritysten brändiviestintä

2010

Tutkimuksen tarkoituksena oli kuvata suomalaisten designyritysten ylimmän johdon käsityksiä ja kokemuksia brändiviestinnästä. Lisäksi haluttiin selvittää brändistrategian ja viestintästrategian ominaispiirteitä, niiden merkitystä designyritysten toiminnalle ja vaikutusta brändiviestinnän sisältöön ja toteutukseen. Brändiviestintää tutkittiin kansainvälisyyden, vaikuttamisen keinojen, vaikuttamisen haasteiden ja niiden hallinnan kautta. Lopuksi haluttiin vielä selvittää, millaisena designyrityksen ylin johto näkee oman roolinsa viestinnän johtamisessa. Tutkimus toteutettiin teema-haastatteluna. Tutkimuksessa haastateltiin seitsemän suomalaisen designyrityksen kahdeksaa ylimmän johdon edustaj…

Geometry control of the junction between two fractal curves

2012

International audience; The general objective of our work is to create a geometric modeller based on iterative processes. With this objective in mind, we have to provide tools that work with fractal objects in the same manner as with objects of classical topology. In this article we focus on the constructing of an intermediate curve between two other curves defined by different iterative construction processes. A similar problem often arises with subdivision surfaces, when the goal is to connect two surfaces with different subdivision masks. We start by dealing with curves, willing to later generalise our approach to surfaces. We formalise the problem with the Boundary Controlled Iterated F…

Fast 3D Ray Tracing for Indoor Coverage Solutions

2016

Optimal wireless indoor network planning requires huge number of iterations and evaluations of indoor coverage for each antenna location until an optimal solution is reached. Consequently, accurate and scalable calculation of power strength for indoor scenarios becomes necessary. The contribution in this paper is to reduce the complexity of 3D ray tracing for deterministic indoor power prediction. In order to achieve that while preserving the accuracy, image theory with feasible reflection volume as preprocessing approach is introduced. This proposed algorithm stores the image, its feasible reflection volume and valid area of receiving points. Significant complexity reduction is achieved by…

Use of a new aneurysm clip with an inverted-spring mechanism to facilitate visual control during clip application. Technical note.

1995

✓ When operating on deep-seated cerebral aneurysms, the surgeon's visual control of clip application may be impaired by the clip holder unless adjacent structures are retracted. To improve visual control and reduce the necessity for retraction, the senior author (A.P.) developed a new concept: an aneurysm clip with an inverted-spring mechanism. The clip has two jaws that point away from the clip blades. The jaws of the clip holder articulate with the inner side of the clip jaws. By distending the jaws of the clip holder the blades of the clip are opened and vice versa. Thus the visual field increases while the clip application is proceeding. This instrumentation is useful, especially in cas…

Localization-Free Power Cartography

2018

Author's accepted manuscript (postprint). © 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. Spectrum cartography constructs maps of metrics such as channel gain or received signal power across a geographic area of interest using measurements of spatially distributed sensors. Applications of these maps include network planning, interference coordination, power con…

Automating statistical diagrammatic representations with data characterization

2017

The search for an efficient method to enhance data cognition is especially important when managing data from multidimensional databases. Open data policies have dramatically increased not only the volume of data available to the public, but also the need to automate the translation of data into efficient graphical representations. Graphic automation involves producing an algorithm that necessarily contains inputs derived from the type of data. A set of rules are then applied to combine the input variables and produce a graphical representation. Automated systems, however, fail to provide an efficient graphical representation because they only consider either a one-dimensional characterizat…

Novel Three-Phase Multilevel Inverter With Reduced Components for Low- and High-Voltage Applications

2021

In this article, a novel multilevel topology for three-phase applications, having three-level and hybrid N -level modular configurations, enabling low-, medium-, and high-voltage operations, is presented. The proposed topology has several attractive features, namely reduced component count, being capacitor-, inductor-, and diode-free, lowering cost, control-complexity, and size, and can operate in a wide range of voltages and powers. Selected simulation and experimental results are presented to verify the performance of the proposed topology. Further, the overall efficiency of the topology and loss distribution in switches are studied. Finally, the key features of the proposed topology in t…