Search results for "Design"
showing 10 items of 5885 documents
Tempting to Tag : An Experimental Comparison of Four Tagging Input Mechanisms
2010
Tagging helps achieve improved indexing and recommendation of resources (e.g., videos or pictures) in large data collections. In order to reap the benefits of tagging, people must be persuaded to label the resources they consume. This paper reports on a study in which four different tagging input mechanisms and their effect on users’ motivation to tag were compared. The mechanisms consisted of a standard tag input box, a chatbot-like environment, a bookmarking mechanism, and a “tag and vote” game. The results of our experiment show that the use of the nonstandard tagging input mechanisms does not affect users’ motivation to tag. In some instances tagging mechanisms were found to distract us…
Conocimiento, traza e ingenio en la arquitectura valenciana del siglo XV
2012
In the last decades historiography of gothic architecture in the Crown of Aragon has focused on buildings monographs, documentary research and technical change in stone building. On the other hand, historians of technology have given special attention to the issue of innovation and its diffusion in the late Middle Ages, considering building techniques as a particular field of research. This essay studies transmission of technical knowledge in building trades in order to explain architectural changes in an outstanding environment of innovation such as the kingdom of Valencia in the 14th and 15th centuries, especially from 1430 onwards. Having account of previous research and some cases of st…
Pareto frontier in economic-statistical design of a dynamic c chart
2015
The present paper proposes an economic-statistical multi-objective design procedure for a dynamic c control chart. In detail, a mixed integer non-linear constrained mathematical model is formulated to solve the treated problem, whereas the Pareto frontier is described by the ε-constraint method. To show the employment of the proposed procedure a numerical case is solved and the related considerations are given.
Structural Design of Frames Able to Prevent Element Buckling
2012
Two formulations of a special multicriterion optimal design problem devoted to elastic perfectly plastic steel frame structures subjected to different combinations of static and dynamic loads are presented. In particular, two minimum volume design problem formulations are proposed: in the first one the structure is designed so as to be able to elastically behave for the assigned fixed loads, to elastically shakedown for serviceability seismic load conditions and to prevent the instantaneous collapse for suitably chosen combinations of fixed and ultimate seismic loadings; in the second one the structure must also satisfy further appropriate constraints related to element buckling. The action…
Myotonic dystrophy: candidate small molecule therapeutics
2017
Myotonic dystrophy type 1 (DM1) is a rare multisystemic neuromuscular disorder caused by expansion of CTG trinucleotide repeats in the noncoding region of the DMPK gene. Mutant DMPK transcripts are toxic and alter gene expression at several levels. Chiefly, the secondary structure formed by CUGs has a strong propensity to capture and retain proteins, like those of the muscleblind-like (MBNL) family. Sequestered MBNL proteins cannot then fulfill their normal functions. Many therapeutic approaches have been explored to reverse these pathological consequences. Here, we review the myriad of small molecules that have been proposed for DM1, including examples obtained from computational rational …
The Retrograde Tibial Nail: presentation and biomechanical evaluation of a new concept in the treatment of distal tibia fractures.
2013
Displaced distal tibia fractures require stable fixation while minimizing secondary damage to the soft tissues by the surgical approach and implants. Antegrade intramedullary nailing has become an alternative to plate osteosynthesis for the treatment of distal metaphyseal fractures over the past two decades. While retrograde intramedullary nailing is a standard procedure in other long bone fractures, only few attempts have been made on retrograde nailing of tibial fractures. The main reasons are difficulties of finding an ideal entry portal and the lack of an ideal implant for retrograde insertion. The Retrograde Tibial Nail (RTN) is a prototype intramedullary implant developed by our group…
A ten-year follow-up of the Reflection cementless acetabular component.
2008
We reviewed the long-term results at ten to 12 years of 118 total hip replacements in 109 patients using a second-generation hemispherical cementless acetabular component (Reflection) designed to address the problem of backside wear. Five patients (five hips) died and six patients (seven hips) were lost to follow-up. The remaining 98 patients (106 hips) had a mean age of 62.9 years (34.0 to 86.2) A rate of revision for aseptic loosening of 0.9%, and predictable results were found with respect to radiological evidence of fixation, lack of pain, walking ability, range of movement and function. One component was revised for aseptic loosening, and of the 101 hips (95.2%) that did not have a rev…
The influence of lateral release on patello-femoral joint loading in knee arthroplasty
1992
Eight fresh, cadaveric knees have been fitted with four different total knee cemented prostheses. Loading forces at the bone implant fixation interface of the patella component have been measured in a knee joint testing rig by four miniaturized force transducers, before and after a lateral release of the patellar retinaculum. The lateral release resulted in a significant local force reduction in the lateral and/or proximal quadrant of the patella resection plane depending on the knee flexion angle, quadriceps tensile force direction, and the patellar prosthesis design.
Biomechanical effectiveness of a distraction-rotation knee brace in medial knee osteoarthritis: preliminary results.
2013
Abstract Background Non-pharmacological therapies are recommended for the care of knee osteoarthritis patients. Unloader knee braces provide an interesting functional approach, which aims to modulate mechanical stress on the symptomatic joint compartment. We aimed to confirm the biomechanical effects and evaluate functional benefits of a new knee brace that combines a valgus effect with knee and tibial external rotation during gait in medial osteoarthritis patients. Methods Twenty patients with unilateral symptomatic medial knee osteoarthritis were included and they performed two test sessions of 3D gait analysis with and without the brace at the initial evaluation (W0) and after 5weeks (W5…
Optimal positioning of the humeral component in the reverse shoulder prosthesis.
2014
Total reverse shoulder arthroplasty is becoming more and more the standard therapeutic practice for glenohumeral arthropathy with massive lesions of the rotator cuff. The biomechanical principle of this prosthesis is represented by the reversion of the normal anatomy of the shoulder joint. This non-anatomical prosthesis leads to a medialization of the rotation centre of the glenohumeral joint and also to a distalization of the humeral head. All that causes a deltoid tension increasing so allowing a larger abduction of the arm. Main complications of the reverse shoulder prosthesis are due to the joint instability, the scapular notching and the wear of the polyethylene insert. The main goal o…