Search results for "Design"
showing 10 items of 5885 documents
Proposal of an innovation framework in an international manufacturing company
2017
Nowadays, companies have to innovate to cope with competition. Several types of innovation exist and have been studied for decades by many authors. However, not many types of innovation are really set up in manufacturing companies operating in a B2B market, and even less the innovation led by users. As far as we know, the specific features of innovation in companies operating in a B2B market have not been greatly studied. Thus, managing innovation in these companies becomes a challenge. The aim of our paper is to analyze the types of innovation which are really set up in a manufacturing company. We also propose an innovation framework. An exploratory experimental study in an international m…
Competition Logics during Digital Platform Evolution
2018
How are platforms built and how do they evolve? This is a salient question in digital ecosystems, where the competition has moved from traditional one-sided business logics to multi-sided platforms. In this paper, we explore how a digital platform evolves when the organization of the multilayered platform architecture, and related control points, is modified through competitive moves. We also examine how a firm may be able to manage the increased complexity of the platform. We show that when technical and strategic bottlenecks are solved, the platform owner can expand control to strategically important layers of the platform stack. The findings indicate that the complexity of the platform i…
Goalkeeper: A Zero-Sum Exergame for Motivating Physical Activity
2021
Incentives and peer competition have so far been employed independently for increasing physical activity. In this paper, we introduce Goalkeeper, a mobile application that utilizes deposit contracts for motivating physical activity in group settings. Goalkeeper enables one to set up a physical exercise challenge with a group of peers that deposit a fixed amount of money for participating. If a peer fails to complete the challenge, Goalkeeper redistributes their deposit to those who managed to complete it (i.e., zero-sum game). We evaluated the potential of Goalkeeper in increasing physical activity with a total of 50 participants over the course of 2 months. Our findings suggest that deposi…
The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: A systematic review wi…
2017
Background Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed psychiatric disorders in childhood. A wide variety of treatments have been used for the management of ADHD. We aimed to compare the efficacy and safety of pharmacological, psychological and complementary and alternative medicine interventions for the treatment of ADHD in children and adolescents. Methods and findings We performed a systematic review with network meta-analyses. Randomised controlled trials (≥ 3 weeks follow-up) were identified from published and unpublished sources through searches in PubMed and the Cochrane Library (up to April 7, 2016). Interventions of interest were pharmacolo…
The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: protocol for a systema…
2015
[Background] Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of children and adolescents, with a significant impact on health services and the community in terms of economic and social burdens. The objective of this systematic review will be to evaluate the comparative efficacy and safety of pharmacological and non-pharmacological treatments in children and adolescents with ADHD.
Are there any differences in various polyaxial locking systems? A mechanical study of different locking screws in multidirectional angular stable dis…
2012
Numerous angular stable plates for the distal radius exist, and technically based comparisons of the polyaxial locking interfaces are lacking. The aim of this mechanical study was to investigate three different locking interfaces of angular stable volar plates by cantilever bending: VA-LCP Two-Column Distal Radius Plates 2.4 mm (Synthes® GmbH, Oberdorf, Switzerland), IXOS® P4 (Martin, Tuttlingen, Germany) and VariAX™ (Stryker®, Duisburg, Germany). We assessed the strength of 0°, 5°, 10° and 15° screw locking angles and tested the bending strength from 10° to 5° angles by cyclic loading until breakage. The final setup repeated the above assessments by inclusion of four locking screws. The si…
Achieving energy efficiency in data centers with a performance-guaranteed power aware routing
2017
Nowadays, data centers are designed to offer the highest performance in case of high traffic load and peak utilisation of the network. However, in a realistic data center environment, the peak capacity of the network is rarely reached and the average utilisation of devices varies between 5% and 25% which results into a huge loss of energy since most of the time links and servers are idle or under-utilized. The high impact of this wasted power on environmental effects, energy needs and electricity costs raised the concerns to seek for an efficient solution to make data centers more power effective while keeping the desired quality of service. In this paper, we propose a power-aware routing a…
Efficient estimation of tuned liquid column damper inerter (TLCDI) parameters for seismic control of base‐isolated structures
2022
This paper presents an enhanced base-isolation (BI) system equipped with a novel passive control device composed of a tuned liquid damper and an inerter (TLCDI). With the aim of reducing the seismic response of BI systems, this contribution focuses on the design of the TLCDI providing analytical solutions for the optimal TLCDI parameters, easily implementable in the design phase. The effectiveness of the proposed approach in terms of seismic response reduction and computational gain is validated by comparison with classical numerical optimization techniques. The control performance of two different base-isolated TLCDI-controlled structures is assessed by employing real-ground motion records…
Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics
2021
To date, computational approaches have been recognized as a key component in drug design and discovery workflows. Developed to help researchers save time and reduce costs, several computational tools have been developed and implemented in the last twenty years. At present, they are routinely used to identify a therapeutic target, understand ligand–protein and protein–protein interactions, and identify orthosteric and allosteric binding sites, but their primary use remains the identification of hits through ligand-based and structure-based virtual screening and the optimization of lead compounds, followed by the estimation of the binding free energy. The repurposing of an old drug for the tr…