Search results for "Design"

Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2

2020

Abstract Inhibition of coronavirus (CoV)‐encoded papain‐like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure‐activity relationships (SAR) of the noncovalent active‐site directed inhibitor (R)‐5‐amino‐2‐methyl‐N‐(1‐(naphthalen‐1‐yl)ethyl) benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS‐CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PLpro inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS‐CoV‐2 replication in …

Efficient boundary integral-resonant mode expansion method implementation for full-wave analysis of passive devices based on circular waveguides with…

2013

In this study, the efficient full-wave analysis of passive devices composed of circular and arbitrarily-shaped waveguides is considered. For this purpose, the well-known boundary integral-resonant mode expansion (BI RME) method has been properly extended. Circular waveguides are used for resonant mode expansion, whereas the arbitrary contour is defined by any combination of straight, circular and elliptical segments, thus allowing the exact representation of the most widely used geometries. The proposed algorithm extends previous implementations of the BI RME method based on circular waveguides by considering circular and elliptical arcs for defining arbitrary geometries. Similarly, it allo…

Numerical methods in the design process of a sailing yacht

2014

Serious Games for Health and Safety Training

2011

EUROSTAT figures show that 5720 people die in the European Union every year as a consequence of work-related accidents. Training in Health and Safety is indeed a key aspect to reduce this figure, and serious games constitute an effective method to provide this training. However, the development of this type of computer applications is a complex issue, requiring cross discipline knowledge on different areas, including instructional design, psychology, sociology, law, and computer graphics. Beyond the challenges already present in the development of non-educational computer games, serious games for health and safety are instructional tools. Therefore, they require an instructional design to c…

A Random Trajectory Approach for the Development of Nonstationary Channel Models Capturing Different Scales of Fading

2017

This paper introduces a new approach to developing stochastic nonstationary channel models, the randomness of which originates from a random trajectory of the mobile station (MS) rather than from the scattering area. The new approach is employed by utilizing a random trajectory model based on the primitives of Brownian fields (BFs), whereas the position of scatterers can be generated from an arbitrarily 2-D distribution function. The employed trajectory model generates random paths along which the MS travels from a given starting point to a fixed predefined destination point. To capture the path loss, the gain of each multipath component is modeled by a negative power law applied to the tra…

Throughput and delay analysis of HARQ with code combining over double Rayleigh fading channels

2018

This paper proposes the use of hybrid automatic repeat request (HARQ) with code combining (HARQ-CC) to offer reliable communications over double Rayleigh channels. The double Rayleigh fading channel is of particular interest to vehicleto-vehicle communication systems as well as amplify-and-forward relaying and keyhole channels. This paper studies the performance of HARQ-CC over double Rayleigh channels from an information theoretic perspective. Analytical approximations are derived for the ϵ-outage capacity, the average number of transmissions, and the throughput of HARQ-CC. Moreover, we evaluate the delay experienced by Poisson-arriving packets for HARQ-CC. We provide analytical expression…

Modeling and Performance Analysis of Channel Assembling in Multichannel Cognitive Radio Networks With Spectrum Adaptation

2012

[EN] To accommodate spectrum access in multichannel cognitive radio networks (CRNs), the channel-assembling technique, which combines several channels together as one channel, has been proposed in many medium access control (MAC) protocols. However, analytical models for CRNs enabled with this technique have not been thoroughly investigated. In this paper, two representative channel-assembling strategies that consider spectrum adaptation and heterogeneous traffic are proposed, and the performance of these strategies is evaluated based on the proposed continuous-time Markov chain (CTMC) models. Moreover, approximations of these models in the quasistationary regime are analyzed, and closed-fo…

Location of navigation menus in websites: an experimental study with Arabic users

2015

Published online: 31 October 2015 While Arabic users represent by far the fastest growing language population on the Internet, research about how the peculiarities of Arabic language may shape users’ web interactions is still scarce. The preferences of Arabic users for menu location in websites have been studied. Two competing arguments have been proposed regarding the best location of menus in websites: conventional design (navigation menu should be placed on that side where users expect it based on previous experience) and reading direction (navigation menu should be placed on that side where readers are used to start off reading, so that the navigation menu is likely to be attended first…

Adaptive Service Offloading for Revenue Maximization in Mobile Edge Computing With Delay-Constraint

2019

Mobile Edge Computing (MEC) is an important and effective platform to offload the computational services of modern mobile applications, and has gained tremendous attention from various research communities. For delay and resource constrained mobile devices, the important issues include: 1) minimization of the service latency; 2) optimal revenue maximization; 3) high quality-of-service (QoS) requirement to offload the computational service offloading. To address the above issues, an adaptive service offloading scheme is designed to provide the maximum revenue and service utilization to MEC. Unlike most of the existing works, we consider both the delay-tolerant and delay-constraint services i…

SAGECELL: Software-Defined Space-Air-Ground Integrated Moving Cells

2018

Ultra-dense networks (UDNs) provide an effective solution to accommodate the explosively growing data traffic of multimedia services and real-time applications. However, the densification of large numbers of static small cells faces many fundamental challenges, including deployment cost, energy consumption and control, and so on. This motivates us to develop software-defined space-air-ground integrated moving cells (SAGECELL), a programmable, scalable, and flexible framework to integrate space, air, and ground resources for matching dynamic traffic demands with network capacity supplies. First, we provide a comprehensive review of state-of-the-art literature. Then the conceptual architectur…