Search results for "Development"

Classifying economics for the common good : a note on the links between sustainable development goals and JEL codes

2021

Purpose This brief note sheds light on the links between Journal of Economic Literature (JEL) codes and the Sustainable Development Goals (SDGs) of the United Nations. Design/methodology/approach Three alternative methods based on keyword overlap to establish links between SDGs and JEL codes are presented. Findings These simple linkages illustrate that the themes of SDGs have corresponding closely related JEL classification codes. Research limitations/implications The mappings presented in this note are based on simple keyword overlap and are therefore necessarily imperfect and incomplete. There is plenty of room for further development. Practical implications Despite the demonstrated possi…

Retinal Straylight Before and After Penetrating Keratoplasty in an Eye with a Post-Herpetic Corneal Scar

2008

Objetivo: Estudio in vivo de la luz dispersa que alcanza la retina en un paciente antes y despues de someterse a una queratoplastia penetrante (o sus siglas en ingles, PKP). Metodos: En un paciente varon de 65 anos con una ulcera corneal herpetica se midio la proporcion de luz dispersa que alcanza la retina tanto antes como despues de una PKP, utilizando para ello un metodo psicometrico denominado "de comparacion por compensacion" («Compensation comparison method», C-Quant straylightmeter, Oculus GmbH, Alemania). Resultados: La cantidad de luz dispersa que alcanza la retina medida antes de la cirugia fue elevada en comparacion con los valores obtenidos en estudios previos en sujetos normale…

Differences in intercellular communication during clinical relapse and gadolinium-enhanced MRI in patients with relapsing remitting multiple sclerosi…

2018

This study was designed based on the hypothesis that changes in both the levels and surface marker expression of extracellular vesicles (EVs) isolated from the cerebrospinal fluid (CSF) may be associated with the clinical form, disease activity, and severity of multiple sclerosis (MS). The analyzes were performed on subjects affected by MS or other neurological disorders. EVs, which were isolated by ultracentrifugation of CSF samples, were characterized by flow cytometry. A panel of fluorescent antibodies was used to identify the EV origin: CD4, CCR3, CCR5, CD19, and CD200, as well as isolectin IB4. The Mann–Whitney U-test and Kruskal–Wallis test were used for statistical analyzes. EVs isol…

Discovery of Retinoic Acid-Related Orphan Receptor γt Inverse Agonists via Docking and Negative Image-Based Screening

2018

Retinoic acid-related orphan receptor γt (RORγt) has a vital role in the differentiation of T-helper 17 (TH17) cells. Potent and specific RORγt inverse agonists are sought for treating TH17-related diseases such as psoriasis, rheumatoid arthritis, and type 1 diabetes. Here, the aim was to discover novel RORγt ligands using both standard molecular docking and negative image-based screening. Interestingly, both of these in silico techniques put forward mostly the same compounds for experimental testing. In total, 11 of the 34 molecules purchased for testing were verified as RORγt inverse agonists, thus making the effective hit rate 32%. The pIC50 values for the compounds varied from 4.9 (11 μ…

Teaching sourcing during online inquiry – adolescents with the weakest skills benefited the most

2022

AbstractSourcing - identifying, evaluating, and using information about the sources of information - assists readers in determining what to trust when seeking information on the Internet. To survive in the post-truth era, students should be equipped with sufficient sourcing skills. This study investigated the efficacy of a teacher-led intervention aimed at fostering upper secondary school students’ (N = 365) sourcing during online inquiry. The intervention (4 × 75 min) was structured in accordance with the phases of online inquiry: locating, evaluating, synthesizing, and communicating information. During the intervention, teachers demonstrated why and how to source, and students practiced s…

ATTACHMENT TO PLACE AND COMMUNITY TIES IN TWO SUBURBS OF JYVÄSKYLÄ, CENTRAL FINLAND

2023

This article describes varied place attachments manifested in public (communal) places in the two socioeconomically weakest suburbs of the city of Jyväskylä in central Finland. We conducted ethnographic research and observations, interviewed local experts on their views of the suburbs, and analysed discourses from various places where residents’ experiences of identity and social relations are connected to residential and community attachment. Our results show a strong connection to place evolving in both suburbs through bonds to the physical and the social environment. The local experts reported social connectedness and sense of belonging among the residents of both suburbs. The strength o…

The Correlation Between Human Capital and Gross Added Value in the Bioeconomy Sectors at the European Union (EU) Country Level

2019

Abstract The paper aims to prove the link between human capital and gross added value in bioeconomy sectors in the EU countries. Data from EUROSTAT data base regarding employment and gross added value in 6 bioeconomy sectors were used in a cross-country regression analysis. The econometric analysis of cross-country data shows a positive correlation between human capital in bioeconomy sectors and their gross output in 2015 in 26 European countries. It is found also that the correlation is stronger in the highly developed economies as in the central-eastern countries, as well as in the European economy.

Xrn1 influence on gene transcription results from the combination of general effects on elongating RNA pol II and gene-specific chromatin configurati…

2020

mRNA homoeostasis is favoured by crosstalk between transcription and degradation machineries. Both the Ccr4-Not and the Xrn1-decaysome complexes have been described to influence transcription. While Ccr4-Not has been shown to directly stimulate transcription elongation, the information available on how Xrn1 influences transcription is scarce and contradictory. In this study we have addressed this issue by mapping RNA polymerase II (RNA pol II) at high resolution, using CRAC and BioGRO-seq techniques in Saccharomyces cerevisiae. We found significant effects of Xrn1 perturbation on RNA pol II profiles across the genome. RNA pol II profiles at 5ʹ exhibited significant alterations that were com…

Kuvien maaseutu : maaseutumaisemakuvaston luomat mielikuvat suomalaisesta maaseutukulttuurista

2013

The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A

2021

Protein phosphatase 2A (PP2A) activity is critical for maintaining normal physiological cellular functions. PP2A is inhibited by endogenous inhibitor proteins in several pathological conditions including cancer. A PP2A inhibitor protein, ARPP-19, has recently been connected to several human cancer types. Accordingly, the knowledge about ARPP-19—PP2A inhibition mechanism is crucial for the understanding the disease development and the therapeutic targeting of ARPP-19—PP2A. Here, we show the first structural characterization of ARPP-19, and its splice variant ARPP-16 using NMR spectroscopy, and SAXS. The results reveal that both ARPP proteins are intrinsically disordered but contain transient…