Search results for "Development"
showing 10 items of 26949 documents
Illness perceptions of COVID-19 in Europe: Predictors, impacts and temporal evolution
2021
Objective: Illness perceptions (IP) are important predictors of emotional and behavioral responses in many diseases. The current study aims to investigate the COVID-19-related IP throughout Europe. The specific goals are to understand the temporal development, identify predictors (within demographics and contact with COVID-19) and examine the impacts of IP on perceived stress and preventive behaviors. Methods: This was a time-series-cross-section study of 7, 032 participants from 16 European countries using multilevel modeling from April to June 2020. IP were measured with the Brief Illness Perception Questionnaire. Temporal patterns were observed considering the date of participation and t…
An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development.
2010
Abstract Fetal trophoblast cells invading the decidua in the early phase of pregnancy establish complex interaction with the maternal extracellular matrix. We discovered that C1q was widely distributed in human decidual stroma in the absence of C4 and C3 and was actively synthesized by migrating extravillous trophoblasts. The cells expressed the messages for the three chains of C1q and secreted this complement component that interacted with the proteins of the decidual extracellular matrix. Solid phase-bound C1q promoted trophoblast adhesion and migration, and cell binding to C1q resulted in activation of ERK1/2 MAPKs. Ab inhibition experiments showed that the receptors for the globular hea…
Arterial thrombosis in Philadelphia-negative myeloproliferative neoplasms predicts second cancer: a case-control study.
2020
Abstract Patients with Philadelphia-negative myeloproliferative neoplasm (MPN) are prone to the development of second cancers, but the factors associated with these events have been poorly explored. In an international nested case-control study, we recruited 647 patients with carcinoma, nonmelanoma skin cancer, hematological second cancer, and melanoma diagnosed concurrently or after MPN diagnosis. Up to 3 control patients without a history of cancer and matched with each case for center, sex, age at MPN diagnosis, date of diagnosis, and MPN disease duration were included (n = 1234). Cases were comparable to controls for MPN type, driver mutations and cardiovascular risk factors. The freque…
Neuropsychological correlates of emotional lability in children with ADHD
2012
Background: Emotional lability (EL) is commonly seen in patients with attention-deficit/hyperactivity disorder (ADHD). The reasons for this association remain currently unknown. To address this question, we examined the relationship between ADHD and EL symptoms, and performance on a range of neuropsychological tasks to clarify whether EL symptoms are predicted by particular cognitive and/or motivational dysfunctions and whether these associations are mediated by the presence of ADHD symptoms. Methods: A large multi-site sample of 424 carefully diagnosed ADHD cases and 564 unaffected siblings and controls aged 618 years performed a broad neuropsychological test battery, including a Go/No-Go …
Heritability of corneal refraction and corneal astigmatism: a population-based twin study among 66- to 79-year-old female twins.
2012
. Purpose: To examine the heritability of corneal refraction power (CR) and corneal astigmatism (AST) in older women. Methods: Corneal refraction and AST were measured by IOL master in 52 monozygotic (MZ) and 47 dizygotic (DZ) female twin pairs aged 66–79 years. The relative contribution of genetic and environmental factors to individual differences in CR was estimated by applying an independent pathway model to the twin data and AST by intraclass correlations (ICC). Results: For the right eye, mean CR was 44.58 dioptres (D) (standard deviation (SD) ±1.28) When comparing CR of the right and left eye between MZ and DZ, no significant difference was found. Mean AST was 0.77 D (SD ±0.44) wi…
Testosterone and cortisol responses to competitive fighting in human males: A pilot study
1987
Departamento de Psicologia Fisiologica (A.S., V.S., F.S.) and Laboratorio de MedicinaNuclear e Isotopos (L.L.), Hospital Clinico Universitario, Universitat de Valencia, Valencia,SpainSerum testosterone and cortisol levels were measured by radioimmunoassay in 14young male judo competitors, in samples taken 10 minutes before and 45 minutes aftertwo different pr(Redures. The first involved physical exercise and the second competi-tive fighting. Both procedures were of 5 minutes duration and sessions took plate atthe same time (between 10:00 \.M. and 12:00 P.M. liR-al lime) but on different days.Comparing the two situations over all subjects revealed that testosterone increasedafter exercise an…
Transient expression of synaptogyrin in the ganglionic eminence of the human fetal brain
2000
Summary The ganglionic eminence (GE) representing a conspicuous bulb-like elevation of the telencephalic proliferative zone has recently been shown to be involved in the establishment of cortical connections. This study demonstrates the presence of synaptogyrin-immunoreactivity in a large number of cell bodies of the human GE between 12 and 20 weeks of gestation. From the 20 th week onwards synaptogyrin expression sharply declines. No immunoreactive structures are detectable in the 23 rd week or later. As the GE persists nearly throughout the entire fetal period these results show that its neurochemical features change distinctly in the course of development. The synaptogyrin-immunoreactive…
El consumo abusivo de alcohol en inmigrantes latinoamericanos que participan en programas de intervención para maltratadores: importancia de la adher…
2016
En este estudio se analizan las tasas de abandono del tratamiento en hombres inmigrantes latinoamericanos con problemas de consumo de alcohol (PCA) derivados a programas de intervención con maltratadores y se explora si aquellos que consiguen finalizar la intervención se diferencian de los que no tienen PCA en variables resultado de la intervención. La muestra la componen 107 hombres latinoamericanos condenados por violencia contra la mujer. Al contrario de lo esperado, no se confirman mayores tasas de abandono entre los participantes con PCA. Independientemente de tener o no PCA, los participantes que finalizaron el programa mostraron mejoría en todas las variables objetivo de la intervenc…
Reliability Assessment of Scores from Video-Recorded TGMD-3 Performances
2017
This study examined the intrarater and interrater reliability of the Test of Gross Motor Development—3rd Edition (TGMD-3). Participants were 60 Finnish children aged between 3 and 9 years, divided into three separate samples of 20. Two samples of 20 were used to examine the intrarater reliability of two different assessors, and the third sample of 20 was used to establish interrater reliability. Children’s TGMD-3 performances were video-recorded and later assessed using an intraclass correlation coefficient, a kappa statistic, and a percent agreement calculation. The intrarater reliability of the locomotor subtest, ball skills subtest, and gross motor total score ranged from 0.69 to 0.77, a…
Dietary polyunsaturated fatty acids, intraocular pressure, and glaucoma
2014
Abstract Glaucoma is a progressive optic neuropathy and is the second leading cause of blindness worldwide. Estimations predict that nearly 80 million people will be affected by the disease in 2020. Increased intraocular pressure (IOP) has been recognized as a major risk factor for developing glaucoma. Although IOP-lowering agents have been shown to be effective for decreasing the progression of glaucoma, extensive research has been done to identify modifiable lifestyle factors involved in the pathogenesis of this disease. Among these factors, dietary lipids and particularly dietary polyunsaturated fatty acids (PUFAs) represent a promising approach. The aim of this chapter is to summarize t…