Search results for "Development"
showing 10 items of 26949 documents
Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits
2014
In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48, via the editing of a single nucleotide in the APOB mRNA by the APOBEC1 enzyme. The APOB48 protein is mandatory for the synthesis of chylomicrons by intestinal cells to transport dietary lipids and cholesterol. We produced transgenic rabbits expressing permanently and ubiquitously a small hairpin RNA targeting the rabbit APOBEC1 mRNA. These rabbits exhibited a moderately but significantly reduced …
Yhtenäisyyttä rakentava peruskoulu – yhtenäisen perusopetuksen ehdot ja mahdollisuudet
2007
Koulu ja perusopetus ovat toiveiden, vaateiden ja odotusten myllerryskenttä. Koulun ja perusopetuksen kehittäminen on myös keskeinen tulevaisuuden haasteisiin vastaamisen keino. Lapselle ja nuorelle koulu näyttäytyy puolestaan arkisina kohtaamisina, joissa vertaisryhmän ja aikuisten maailma lomittuu ja usein myös törmää toisiinsa. Tässä teoksessa raportoitu tutkimus on tarttunut uusimpaan suomalaisen peruskoulun uudistukseen: yhtenäisen perusopetuksen kehittämiseen. Yhtenäistä perusopetusta tarkastellaan kirjassa koulun kehittämisen pedagogisena ja yhteisöllisenä haasteena. Tutkimushankkeen tarkoituksena on ollut ymmärrettävän kuvan luominen suomalaista perusopetusta päivittäin toteuttavist…
Isolation of Four Lytic Phages Infecting Klebsiella pneumoniae K22 Clinical Isolates from Spain
2020
This article belongs to the Special Issue Bacteriophage—Molecular Studies.
Career experts’ conceptions of innovation in career development
2021
AbstractThis article reports the findings from a phenomenographic investigation into career experts’ conceptions of innovation in career development. The results show that conceptions of innovation in career development varied from (1) initiating service, (2) developing demographic-based programmes, (3) professionalising the sector to (4) exploiting cross-sectoral synergies. The findings give us a more profound understanding of critical aspects that may have an important role in improving innovation in career development.
Neural phoneme discrimination in variable speech in newborns – associations with dyslexia risk and later language skills
2023
AbstractA crucial skill in infant language acquisition is learning of the native language phonemes. This requires the ability to group complex sounds into distinct auditory categories based on their shared features. Problems in phonetic learning have been suggested to underlie language learning difficulties in dyslexia, a developmental reading-skill deficit. We investigated auditory abilities important for language acquisition in newborns with or without a familial risk for dyslexia with electrophysiological mismatch responses (MMRs). We presented vowel changes in a sequence of acoustically varying vowels, requiring grouping of the stimuli to two phoneme categories. The vowel changes elicit…
Children in the visual coverage of the European refugee crisis: A case study of the World Press Photo 2016
2018
Shifts in the visual coverage of refugees arriving in Europe and prominent compassion fatigue emphasize the need to examine visual strategies utilized to report on the crisis. This study focuses on representations of refugee children using a case of the World Press Photo (WPP) 2016. The material was interpreted with a model for visual rhetorical interpretation of journalistic photographs. Findings indicate the main visual elements involved in representing refugee children: visual trope of the migrant father, relation between children and barriers, visual oxymoron (juxtaposition of contradictory elements) and atmosphere in photographs. Findings suggest that photographs address polemics speci…
Ground-Mounted Photovoltaic and Crop Cultivation: A Comparative Analysis
2022
Human civilization depends on energy sources, mainly fossil fuels. An increase in the prices of fossil fuels and their exhaustibility limit economic growth. Carbon dioxide emission causes global environmental problems. Global crises (including COVID-19) have sharpened food and energy supply problems. The decentralized energy supply systems as well as the expedition of the application of renewable energy may solve these challenges. The economic shift to renewable power generation intensifies the competition between food crop production and green energy for land. This paper applied an open-source spatial-based model to quantify the solar power generation (the ground-mounted photovoltaic panel…
Maternally‐transferred thyroid hormones and life‐history variation in birds
2022
1. In vertebrates, thyroid hormones (THs) play an important role in the regulation of growth, development, metabolism, photoperiodic responses and migration. Maternally transferred THs are important for normal early-phase embryonic development when embryos are not able to produce endogenous THs. Previous studies have shown that variation in maternal THs within the physiological range can influence offspring phenotype. 2. Given the essential functions of maternal THs in development and metabolism, THs may be a mediator of life-history variation across species. 3. We tested the hypothesis that differences in life histories are associated with differences in maternal TH transfer across species…
Initial validation of the Psychobiosocial States in Physical Education (PBS-SPE) scale
2018
The purpose of this cross-sectional investigation was to examine the item characteristics, factor structure, reliability, convergent validity, and nomological validity of the Psychobiosocial States in Physical Education (PBS-SPE) scale. In Study 1, a sample of 1,030 students (582 girls and 448 boys, 10 to 19-year-olds), drawn from middle or high schools, rated the intensity of the 20 items version of the PBS-SPE scale thinking about the feelings they had usually experienced in physical education classes. In Study 2, an additional sample of 1,025 students (578 girls, 447 boys, 10 to 19-year-olds), rated the 16 items of the final version of the scale. Two subsamples also completed an affectiv…
Motorisen oppimisen vaikeuden tunnistaminen ja tukeminen kouluympäristössä
2018
Motorisen oppimisen vaikeudella, kuten kehityksellisellä koordinaatiohäiriöllä (DCD), tarkoitetaan huomattavaa vaikeutta oppia uusia motorisia taitoja ja soveltaa jo opittuja taitoja uusiin tilanteisiin. Tämän tutkimuksen tarkoituksena oli kehittää opettajien käyttöön havainnointityökalu, joka auttaa tunnistamaan motorisen oppimisen vaikeuden esi- ja alkuopetusikäisillä lapsilla. Lisäksi tutkimus selvitti, miten opettajat voivat kouluympäristössä tukea lapsia, joilla on haasteita motorisessa oppimisessa. Tutkimus muodostui neljästä osatutkimuksesta. Ensimmäisessä tutkittiin systemaattisen kirjallisuuskatsauksen avulla maailmalla käytössä olevien havainnointilomakkeiden psykometrisiä ominais…