Search results for "Development"

Zrównoważony rozwój w aspekcie zasady jednomyślności i zasady większości w parlamentaryźmie polskim XVI i XVII wieku (1505-1697)

2017

Nie można mówić o zasadach jednomyślności i większości w parlamentaryźmie polskim XVI i XVII wieku, abstrahując od struktury organów przedstawicielskich, ich kompetencji i konkretnych metod podejmowania decyzji. Przedstawione w artykule analizy pozwalają na stwierdzenie, że pomimo tego, że zasada jednomyślności była charakterystyczna dla społeczeństwa stanowego, to już w wieku XVI w praktyce parlamentarnej decydowano w oparciu o zasadę większości. Objawy kryzysu, tj. konfrontacji pomiędzy zasadami, widoczne są już w dwóch ostatnich dziesięcioleciach XVI w. Od połowy wieku XVII prace parlamentu zdominowała zasada jednomyślności, a właściwie jej konsekwencja - liberum veto, decyzja nie zostaj…

On the Choice of the Extracellular Vesicles for Therapeutic Purposes

2019

Extracellular vesicles (EVs) are lipid membrane vesicles released by all human cells and are widely recognized to be involved in many cellular processes, both in physiological and pathological conditions. They are mediators of cell-cell communication, at both paracrine and systemic levels, and therefore they are active players in cell differentiation, tissue homeostasis, and organ remodeling. Due to their ability to serve as a cargo for proteins, lipids, and nucleic acids, which often reflects the cellular source, they should be considered the future of the natural nanodelivery of bio-compounds. To date, natural nanovesicles, such as exosomes, have been shown to represent a source of diseas…

MTOR inhibitor-based combination therapies for pancreatic cancer

2018

Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…

Self-reported reflective functioning mediates the association between attachment insecurity and well-being among psychotherapists.

2020

Objective: Subjective well-being is a crucial variable for mental health practitioners. This study examines the influence of therapists’ attachment dimensions and self-reported reflective functioning on their perceived well-being. Further, it examines if reflective functioning mediates the association between attachment insecurity and well-being. Method: A total of 416 experienced psychotherapists were enrolled in this cross-sectional study, and completed self-report measures of attachment insecurity, reflective functioning, and well-being. We tested the hypothesized mediation model with path analysis that examined indirect effects. Results: Both attachment anxiety and avoidance dimensions …

Exergoeconomics as a Cost-Accounting Method in Thermal Grids with the Presence of Renewable Energy Producers

2022

Thermal grids are efficient, reliable, and sustainable technologies for satisfying the thermal demands of buildings. The capability to operate at a low temperature allows not only for the integration of heat produced by renewable energy sources but also for the storage of surplus electricity from the grid via “power to heat” technologies. Besides, in the future, heat consumers are expected to behave increasingly as “prosumers”, supplying in some periods heat produced by renewable energy plants on site. In this scenario, it is important to propose a method for the cost allocation among producers connected to the grid. In this regard, this paper proposes Exergoeconomic…

Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.

2013

The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…

The new face of university–business cooperation in Finland

2016

This paper analyses the development of university-business cooperation (UBC) in Finland in the context of the University Reform Act of 2009, drawing on the experience of four universities: Aalto University, University of Jyvaskyla, University of Turku, and Lappeenranta University of Technology. Six UBC dimensions are examined: institutional context, stakeholders, motivations, facilitators/inhibitors, benefits, and drawbacks. We find that UBC, while a relatively recent process, is growing fast in dynamic local innovation and entrepreneurship ecosystems. The University Act of 2009 had an uneven effect on the six UBC dimensions, with the most visible impact being manifested on motivations. Aal…

Editorial: Thymic Epithelial Cells: New Insights Into the Essential Driving Force of T-Cell Differentiation.

2021

Kotimaisilla kielillä julkaistu tutkimus palvelee monia

2022

Pääkirjoitus 3/2022

Information, Communications and Media Technologies for Sustainability: Constructing Data-Driven Policy Narratives

2021

This paper introduces the idea of data-driven narratives to examine how the use of information, communications, and media technologies (ICMTs) impacts the sustainable growth of economies. While ICMTs have regularly been advocated as a policy tool for growth and development, there is a research gap in empirical studies validating how such policies may be effective. This analysis is based on historical panel data from 39 economies across the developed North (19) and developing South (20). The industry-standard Cross-Industry Standard Process for Data Mining (CRISP-DM) methodology was applied to construct narratives that weave extant theories with empirical data. The art of developing data-dri…