Search results for "Dication"

A pilot study demonstrating how inhaled furosemide enhances the bronchodilator effect of salbutamol

1993

Abstract To investigate whether inhaled furosemide can improve the bronchodilator effect of salbutamol, a single-blind crossover study in 10 subjects with stable asthma was designed. Each subject inhaled two puffs of salbutamol (200 μg) 1 hour after premedication with an aerosol preparation of either furosemide or placebo. Forced expiratory volume in 1 second (FEV 1 ) was measured before premedication, again before inhalation of salbutamol, and again 30, 60, and 90 minutes after, and 2, 3, 4, and 5 hours after inhalation of salbutamol. The FEV 1 at each time interval was greater on furosemide days but the difference was significant at 1, 4, and 5 hours after salbutamol inhalation. The areas…

Die Wirkung von Pharmaka auf die Elimination von Noradrenalin aus der Perfusionsfl�ssigkeit und die Noradrenalinaufnahme in das isolierte Herz

1964

Patients' satisfaction with medication during psychiatric inpatient treatment

2000

Die Noradrenalin-Abgabe aus dem isolierten Kaninchenherzen bei sympathischer Nervenreizung und ihre pharmakologische Beeinflussung

1962

Effects on Arterial Blood Pressure of the Methanol and Dichloromethanol Extracts from Schinus molle L. in Rats

1996

The effects on arterial blood pressure of the methanol and dichloromethanol extracts from Schinus molle L. were analysed in urethane anaesthetized rats. In normotensive rats, the mean arterial blood pressure was significantly reduced by the i.v. administration of both extracts. The dichloromethanol extract inhibited the effects of noradrenaline on arterial blood pressure in the anaesthetized rat and it reduced the maximal contractile effect (Emax) induced by noradrenaline on rat vas deferens in the organ bath. However, the methanol extract did not modify the effects of noradrenaline in the evaluated tests.

Cardiovascular effects of the methanol and dichloromethanol extracts fromTeucrium cartaginenses L.

1998

Methanol and dichloromethanol extracts of the leaves and stems of Teucrium cartaginensesL. have been tested for their effects on resting arterial blood pressure, heart rate and noradrenaline induced hypertension. Both extracts administered i.v. to urethane anaesthetized normotensive rats reduced mean arterial blood pressure and heart valve, while only the dichloromethanol extract prevented noradrenaline induced hypertension. © 1998 John Wiley & Sons, Ltd.

Prescription patterns of angiotensin-converting enzyme inhibitors for various indications: A UK population-based study

2018

AIM: Angiotensin‐converting enzyme inhibitors (ACEIs) are widely prescribed for several cardiovascular indications. This study investigated patterns of ACEI use for various indications. METHODS: A descriptive, retrospective population‐based study was conducted using data from the UK Clinical Practice Research Datalink. Patients starting ACEIs (2007–2014) were selected and ACEI indications were retrieved from electronically recorded medical records. Stratified by indication, we distinguished between persistent and nonpersistent ACEI use, considering a 6‐month interval between two prescription periods as a maximum for persistent use. Five‐year persistence rates for various indications were ca…

Pentoxifylline in liver ischemia and reperfusion.

2013

Pentoxifylline is a methylxanthine compound which was first filed in 1973 and registered in 1974 in the United States by Sanofi-Aventis Deustchland Gmbh for the treatment of intermittent claudication for chronic occlusive arterial disease. This methylxanthine was later discovered to be a phosphodiesterase inhibitor. Furthermore, its hemorheological properties and its function as an inhibitor of inflammatory cytokines, like TNF- α, allowed researchers to study its effects in organ ischemia and reperfusion and transplantation. Although this drug has demonstrated beneficial effects, the mechanisms by which Pentoxifylline exerts a protective effect are not fully understood. This paper focuses o…

In vivo investigations on microcirculatory disturbances induced by crenated erythrocytes following norepinephrine application

1974

Using a special apparatus for high resolution cinephotomicrography, which allows simultaneous observation and recording of microcirculatory changes, alterations in blood flow patterns and in red cell shape during norepinephrine acting have been studied. Under physiological conditions, and during slowing of capillary blood flow due to gradual removing of 20–25% of the circulating blood volume, the normal red cells are extremely deformable while passing through mesenteric capillaries. After application of norepinephrine a general arteriolar constrictive response in the bowel wall occurs, causing a further slowing of the capillary blood flow in the mesentery. Under these circumstances the eryt…

Is unintentional doping real, or just an excuse?

2017

Although some athletes who engage in doping do so willingly in order to gain an unfair advantage (ie, ‘to cheat’), the possibility of athletes doping inadvertently or unintentionally cannot be discounted. In this article, we aim to address common misconceptions of the notion of ‘unintentional doping’, and discuss this topic with reference to statistics, reports and recommendations (eg, anti-doping codes) produced by the World Anti-Doping Agency (WADA), together with evidence from recent empirical research. Unintentional doping (also known as ‘inadvertent’ or ‘accidental’ doping) refers to the accidental consumption of performance-enhancing substances included on WADA’s banned list.1 It ofte…