Search results for "Different"

Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells

2015

Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. We demonstrate how this combined effect can be used against canc…

Macrophage Migration Inhibitory Factor Induces Inflammation and Predicts Spinal Progression in Ankylosing Spondylitis

2017

Objective: To investigate the role of macrophage migration inhibitory factor (MIF) in the pathogenesis of ankylosing spondylitis (AS). Methods: Patients who met the modified New York criteria for AS were recruited for the study. Healthy volunteers, rheumatoid arthritis patients, and osteoarthritis patients were included as controls. Based on the annual rate of increase in modified Stoke AS Spine Score (mSASSS), AS patients were classified as progressors or nonprogressors. MIF levels in serum and synovial fluid were quantitated by enzyme-linked immunosorbent assay. Predictors of AS progression were evaluated using logistic regression analysis. Immunohistochemical analysis of ileal tissue was…

Characterization of Anodic Oxides on Titanium by Photocurrent and Differential Admittance Techniques

2010

Characterization of Anodic Oxides on Magnetron Sputtered Ta-Nb Alloys by Photocurrent Spectroscopy and Differential Admittance Measurements

2010

Digestion-free determination of heavy metals (Pb, Cd, Cu) in honey using anodic stripping differential pulse voltammetry and potentiometric stripping…

1995

Experiments have been carried out to assess the potential of differential pulse voltammetry and potential stripping analysis for determining Pb, Cu and Cd directly in dissolved honey samples using a flow-through cell. With the hanging mercury drop electrode Pb alone can be determined only if the electrode is first modified in-situ with Triton X 100 to increase the separation between the Pb peak and a broad, interfering adsorption peak which overlaps the Cu peak. If the (more sensitive) thin film mercury electrode is used the interference encountered is less so also Cu and Cd can be determined. With potentiometric stripping analysis Cu and Pb can be determined using normal procedures. The de…

Emotion regulation in adolescents with anorexia and bulimia nervosa: Differential use of adaptive and maladaptive strategies compared to healthy adol…

2021

Objective: Adolescents with anorexia (AN) and bulimia nervosa (BN) often struggle with emotion regulation (ER). These difficulties have predominantly been assessed across emotions, without considering adaptive and maladaptive ER separately.We compared adolescents with AN or BN to healthy adolescents (HCs) regarding the adaptive and maladaptive ER of three emotions. Methods: A treatment-seeking sample of 197 adolescents (atypical/full-threshold AN: N = 118, atypical/full-threshold BN: N = 32; HC: N = 47) reported emotion-specific ER with the FEEL-KJ questionnaire. Mixed models were calculated for adaptive and maladaptive ER to assess differences between emotions (anxiety, anger, sadness) and…

Altered Mitochondrial Function and Oxidative Stress in Leukocytes of Anorexia Nervosa Patients

2014

ContextAnorexia nervosa is a common illness among adolescents and is characterised by oxidative stress.ObjectiveThe effects of anorexia on mitochondrial function and redox state in leukocytes from anorexic subjects were evaluated.Design and settingA multi-centre, cross-sectional case-control study was performed.PatientsOur study population consisted of 20 anorexic patients and 20 age-matched controls, all of which were Caucasian women.Main outcome measuresAnthropometric and metabolic parameters were evaluated in the study population. To assess whether anorexia nervosa affects mitochondrial function and redox state in leukocytes of anorexic patients, we measured mitochondrial oxygen consumpt…

Molecular bases of anorexia nervosa, bulimia nervosa and binge eating disorder: shedding light on the darkness

2017

International audience; Eating-disorders (EDs) consequences to human health are devastating, involving social, mental, emotional, physical and life-threatening aspects, concluding on impairment and death in cases of extreme anorexia nervosa. It also implies that people suffering an ED need to find psychiatric and psychological help as soon as possible to achieve a fully physical and emotional recovery. Unfortunately, to date, there is a crucial lack of efficient clinical treatment to these disorders. In this review, we present an overview concerning the actual pharmacological and psychological treatments, the knowledge of cells, circuits, neuropeptides, neuromodulators and hormones in the h…

Electromagnetic Sensitivity Analysis and Shape Optimization Using Method of Moments and Automatic Differentiation

2009

Sensitivity analysis is an important part of gradient-based optimization of electromagnetic devices. We demonstrate how sensitivity analysis can be incorporated into an existing in-house method of moments solver with a relatively small amount of labor by using a technique called automatic differentiation (AD). This approach enables us to obtain (geometrical) sensitivities of the discrete solution with accuracy up to numerical precision. We compare the assembly time and memory usage of the modified and original solvers. Moreover, we optimize the shape of a dipole antenna and the dimensions of a Yagi-Uda array using the presented AD technique, traditional response level finite difference sens…

Effects of Extraction Conditions on Bioactive Anthocyanin Content of Vaccinium Corymbosum in the Perspective of Food Applications

2012

Abstract Bioflavonoids, in particular anthocyanins have made the topic of many scientific research, mainly for two reasons: their beneficial effects on human health and applications as potential sources of natural food dyes. Natural extracts of these pigments may also find useful application for textiles dying, as an eco-friendly alternative to synthetic dyes. The aim of the present paper was to apply conventional extraction procedures in order to isolate an enriched crude extract of pigments from highbush blueberries (Vaccinium corymbosum L.). Water, hydroalcoholic solution and acidified alcoholic solvent were tested to extract anthocyanins by a discontinuous process. Also, temperatures of…