Search results for "Differential effects"

Variants associated with HHIP expression have sex-differential effects on lung function

2021

Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P<5x10-8) interactions with sex …

Adaptive modes of rumination: the role of subjective anger.

2015

Rumination has been demonstrated to have negative consequences on affect, behaviour, and physiological markers. Recent studies, however, suggest that distinct "modes" of anger-associated rumination may lead to several positive consequences. Previous research primarily used recall procedures of anger episodes to elicit anger. By contrast, the present study focused on the effect of subjective anger on the process of rumination and tested its effects in a "staged" social interaction where a confederate provoked participants. Subsequently, participants engaged in rumination about the anger-eliciting event either in an abstract-distanced or a concrete-immersed rumination mode. Results showed an …

Differential effects of age on subcomponents of response inhibition.

2013

Inhibitory deficits contribute to cognitive decline in the aging brain. Separating subcomponents of response inhibition may help to resolve contradictions in the existing literature. A total of 49 healthy participants underwent functional magnetic resonance imaging (fMRI) while performing a Go/no-go-, a Simon-, and a Stop-signal task. Regression analyses were conducted to identify correlations of age and activation patterns. Imaging results revealed a differential effect of age on subcomponents of response inhibition. In a simple Go/no-go task (no spatial discrimination), aging was associated with increased activation of the core inhibitory network and parietal areas. In the Simon task, whi…

Differential effects of exhaustive cycle ergometry on concentric and eccentric torque production.

2001

The purpose of this study was to investigate the potential differences in peak isokinetic concentric end eccentric torque following low- and high-intensity cycle exercise fatigue protocols. Ten healthy, recreationally-active men were tested in a balanced, randomized testing sequence for peak eccentric and concentric isokinetic torque (60 degrees/sec) immediately before and after three experimental conditions each separated by 48 hours: 1) a bout of high intensity cycling consisting of a maximal 90-second sprint; 2) a bout of low-intensity cycling at 60 rpm equated for total work with the high-intensity protocol: and 3) no exercise (control bout). Blood was drawn from an antecubital vein and…

When Affective (But Not Cognitive) Ambivalence Predicts Discrimination Toward a Minority Group

2013

Individuals often hold ambivalent attitudes (i.e., positive and negative attitudes at the same time) toward groups and social categories. The aim of the present research was to examine the differential effects of affective and cognitive dimensions of ambivalence on the (amplification of) responses towards a minority group. We asked 188 students from the University of Perugia to read a short description of a fictitious group of immigrants. After expressing their affective and cognitive attitudes toward the target group, participants received positive, negative, or no supplementary information about this group. Discrimination was assessed by asking participants to allocate to the target group…

Previous Training in the Water Maze

1999

It has been shown that acquisition rates in the water maze vary across strains of mice, although the differential effects of previous experience in this spatial task have been scarcely evaluated. The aim of the present study was to evaluate the effects of training in the water maze at an early age (2 months) in two strains of mice (NMRI and C57BL) using a longitudinal study. Mice with or without previous training were tested when they were 6 months, and retested when 10 months old. The results showed that trained NMRI mice performed better than all the other groups, both at test and retest, indicating that previous training had more beneficial effects in NMRI than in C57BL mice. These resul…

Arterial pCO2 and Blood Flow in Different Parts of the Central Nervous System of the Anesthetized Cat

1969

It cannot be regarded as proven that the mechanisms involved in the regulation of local circulation are identical in all parts of the central nervous system. Evidence has been presented that carbon dioxide exerts differential effects in different parts of the CNS [2, 3, 7, 10].

Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress

2007

R&D subsidies & external collaborative breadth: Differential gains and the role of collaboration experience

2018

The file attached to this record is the author's final peer reviewed version. External collaboration breadth is important for firms to acquire the knowledge needed to innovate. In this paper, we combine cross-sectional and longitudinal data from the Spanish Panel of Technological Innovation Survey (PITEC) to examine the indirect impact of R&D subsidies on firm external collaboration breadth. We contribute to understanding of the indirect impacts of R&D subsidies by first providing strong evidence of an economically significant average positive impact of R&D subsidies on firm external collaboration breadth. Second, our results advance understanding of the differential impacts of R&D subsidie…

Cooperation and Status in Organizations

2010

We report the results of experiments designed to test the effect of social status on contributions to a public good, with and without punishment. The experiments are conducted in four-person groups in a “star” network, where one central player observes and is observed by the others. This imposes a social structure on the game, and gives the central player a leadership role in the group, simply by virtue of being commonly observed. We further manipulate status by allocating the central position to the person who earns the highest, or the lowest, score on a trivia quiz. These high-status and low-status treatments are compared, and we find that the effect of organizational structure—the existe…