Search results for "Dihydralazine"

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Propyldazine is mutagenic inSalmonella typhimurium and Escherichia coli: Distinct specificity for strains TA1537 AND TA97

1985

The antihypertensive drug propyldazine (Atensil) was demonstrated to be muta- genic with auxotrophic mutants of Salmonella typhimurium and Escherichia coli. Addition of liver S9 mix (postmitochondrial supernatant fraction supplemented with an NADPH-generating system) had little, if any, effect on the mutagenicity. The mutagenicity showed an unusual pattern of strain specificity. Increased fre- quencies of reversion were observed with all strains whose auxotrophy was caused by frame-shift mutations: the number of revertant colonies per plate from S. typhimurium TA98, TA1538, TA97, and TA1537 was increased up to 5-, 9-, 43-, and 160-fold, respectively, above background. Among the strains that…

MaleSalmonella typhimuriumSalmonellaHealth Toxicology and MutagenesisAuxotrophyReversionMutagenBiologyToxicologymedicine.disease_causeAmes testMicrobiologySpecies SpecificityEscherichia coliGeneticsmedicineAnimalsEscherichia coliBiotransformationGenetics (clinical)DihydralazineStrain (chemistry)Mutagenicity Testsfood and beveragesRats Inbred StrainsHydralazineDihydralazineRatsPyridazinesOncologyMutationMicrosomes LiverMutagensmedicine.drugTeratogenesis, Carcinogenesis, and Mutagenesis

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