Search results for "Dino"
showing 10 items of 490 documents
Effects of SCA40 on human isolated bronchus and human polymorphonuclear leukocytes: comparison with rolipram, SKF94120 and levcromakalim
1996
1. SCA40 (0.1 nM-0.1 mM) produced concentration-dependent suppression of the spontaneous tone of human isolated bronchus (-log EC50 = 6.85 +/- 0.09; n = 10) and reached a maximal relaxation similar to that of theophylline (3 mM). The potency (-log EC50 values) of SCA40 compared to other relaxants was rolipram (7.44 +/- 0.12; n = 9) > SCA40 > or = levcromakalim (6.49 +/- 0.04; n = 6) > SKF94120 (5.87 +/- 0.10; n = 9). 2. When tested against the activity of the isoenzymes of cyclic nucleotide phosphodiesterase (PDE) isolated from human bronchus, SCA40 proved highly potent against PDE III (-log IC50 = 6.47 +/- 0.16; n = 4). It was markedly less potent against PDE IV (4.82 +/- 0.18; n = 4) and …
Developments and contributions in the study of La Rioja dinosaur footprints (Spain)
2020
In this paper the study of dinosaur tracks of La Rioja, which began in 1970, is presented as an example of knowledge development, achievements, and events occurring around a paleontological resource having strong media impact. Fieldwork, research, and dissemination since the publication of the first scientific works have been accompanied by activities to protect sites and consider them as natural and cultural heritage. Finally it is shown how a paleontological resource has also led to the development of the tourist infrastructure in the area
Hoeflea alexandrii sp. nov., isolated from the toxic dinoflagellate Alexandrium minutum AL1V
2006
A Gram-negative, aerobic, non-symbiotic bacterium (AM1V30(T)) was isolated from the toxic dinoflagellate Alexandrium minutum AL1V. On the basis of 16S rRNA gene sequence similarity, strain AM1V30(T) was most closely related (97.4 % similarity) to the type strain of Hoeflea marina, which belongs to the family Phyllobacteriaceae within the order Rhizobiales of the class Alphaproteobacteria. A polyphasic approach was used to clarify the taxonomic position of strain AM1V30(T). During the course of this study, a second species was described by others as belonging to the genus Hoeflea, namely Hoeflea phototrophica; it showed a somewhat higher level of 16S rRNA gene sequence similarity with respec…
Cold stress defense in the freshwater sponge Lubomirskia baicalensis
2007
The endemic freshwater sponge Lubomirskia baicalensis lives in Lake Baikal in winter (samples from March have been studied) under complete ice cover at near 0 degrees C, and in summer in open water at 17 degrees C (September). In March, specimens show high metabolic activity as reflected by the production of gametes. L. baicalensis lives in symbiosis with green dinoflagellates, which are related to Gymnodinium sanguineum. Here we show that these dinoflagellates produce the toxin okadaic acid (OA), which is present as a free molecule as well as in a protein-bound state. In metazoans OA inhibits both protein phosphatase-2A and protein phosphatase-1 (PP1). Only cDNA corresponding to PP1 could …
Traditionally used Thai medicinal plants: in vitro anti-inflammatory, anticancer and antioxidant activities.
2009
In order to assess traditional Thai claims about the therapeutic potential of medicinal plants and to select plants for future phytochemical research, nine plant species with anti-inflammatory uses were selected from Thai textbooks and assessed for their in vitro anti-inflammatory, antiproliferative and antioxidant activities.Nuclear factor-kappaB (NF-kappaB) inhibitory effects in stably transfected HeLa cells were determined by luciferase assay, and effects on LPS-induced pro-inflammatory mediators prostaglandin E2 (PGE2), interleukin (IL)-6, IL-1beta, and tumour necrosis factor (TNF)alpha in primary monocytes were assessed by ELISA. Cytotoxic activities were examined against HeLa cells, h…
On-line preconcentration strategies for analyzing pesticides in fruits and vegetables by micellar electrokinetic chromatography.
2007
Five pesticides (fludioxonil, procymidone, pyriproxyfen, dinoseb and carbendazim) were separated in reversed migration micellar electrokinetic chromatography (RM-MEKC) using 20 mmol l(-1) phosphate buffer at pH 2.3, containing 25 mmol l(-1) sodium dodecylsulfate and 10% methanol. Three on-line concentration strategies, sweeping (SW), normal stacking with reversed migration and a water plug (SRW) and stacking with reverse migration and removal of sample matrix using polarity switching (SRMM), were compared. About 10-, 30- and 50-fold increases in detection sensitivity, compared with standard hydrodynamic injection (5 s at 0.5 psi), were observed with SW, SRW and SRMM, respectively. Limits of…
Between Atoms and Humours. Lucretius' Didactic Poetry as a Model of Integrated and Bifocal Physiology
2012
Lucretius has often been regarded as one of the fathers of modern science, and also in recent years several studies have explored his influence far beyond a merely literary perspective. In this paper I analyse specifically the importance of the poet's 'eclectic' attitude in physiology from the point of view of his 'Fortleben' in early modern thought. I suggest that the typical eclectic combination of physics and biology, atomism and macroscopy, which the 'De rerum natura' shows in its didactic structure both through its images and even more through its conscious scientific reflection, built an attractive basis for attempts in the modern period at harmonising corpuscularian theories and qual…
The importance of a highly active and DeltapH-regulated diatoxanthin epoxidase for the regulation of the PS II antenna function in diadinoxanthin cyc…
2005
The present study focuses on the regulation of diatoxanthin (Dtx) epoxidation in the diadinoxanthin (Ddx) cycle containing algae Phaeodactylum tricornutum, Thalassiosira pseudonana, Cyclotella meneghiniana and Prymnesium parvum and its significance for the control of the photosystem II (PS II) antenna function. Our data show that Dtx epoxidase can exhibit extremely high activities when algal cells are transferred from high light (HL) to low light (LL). Under HL conditions, Dtx epoxidation is strongly inhibited by the light-driven proton gradient. Uncoupling of the cells during HL illumination restores the high epoxidation rates observed during LL. In Ddx cycle containing algae, non-photoche…
Diclofenac sodium and cyclosporin A inhibit human lens epithelial cell proliferation in culture.
1997
• Purpose: To investigate the effect of diclofenac sodium salt and cyclosporin A (CsA) on human lens epithelial cell (HLEC) growth in culture. • Methods: Cultures of HLEC were obtained from anterior capsules from extracapsular cataract surgery. Third-passage cells were seeded in 96-well plates in 0.1 ml culture medium. Cytotoxicity was estimated by the tetrazolium test in confluent monolayers after 24 h exposure to a wide range of concentrations of diclofenac and CsA. The effect of subcytotoxic concentrations of diclofenac and CsA on HLEC proliferation in subconfluent cultures was evaluated after 24 and 72 h of exposure. To investigate the relationship between PGEZ synthesis and the inhibit…
Valentina Polcini, Dino Buzzati and Anglo-American Culture. The Re-use of Visual and Narrative Text in his Fantastic Fiction”, Forme, strategie e mut…
2016
Il volume di Polcini s’iscrive in questo nuovo interesse anglo-americano per lo scrittore italiano e intende rilanciare il dibattito internazionale su Buzzati. Un primo merito del volume infatti consiste nell’avere rintracciato, con dovizia di esempi e attraverso una puntuale analisi della copiosa produzione narrativa di Buzzati, il debito verso la tradizione anglosassone e americana – e per inciso anche quella del Nord Europa. Conrad, Rachkam, Dickens e Melville vengono riconosciuti i suoi grandi maestri. Strettamente intrecciato al primo è il secondo merito del volume. Come è evidente anche dalla fortuna anglosassone dell’autore, non è facile ignorare la componente visuale nell’opera di B…