Search results for "Dino"

Isotopic ordering in eggshells reflects body temperatures and suggests differing thermophysiology in two Cretaceous dinosaurs

2015

International audience; Our understanding of the evolutionary transitions leading to the modern endothermic state of birds and mammals is incomplete, partly because tools available to study the thermo-physiology of extinct vertebrates are limited. Here we show that clumped isotope analysis of eggshells can be used to determine body temperatures of females during periods of ovulation. Late Cretaceous titanosaurid eggshells yield temperatures similar to large modern endo-therms. In contrast, oviraptorid eggshells yield temperatures lower than most modern endotherms but B6 °C higher than co-occurring abiogenic carbonates, implying that this taxon did not have thermoregulation comparable to mod…

Synthesis and biological evaluation of 1,4-oxadiazole analogues of Linezolid

2012

MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate

2019

Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory function for kinase activity and substrate recognition. We report on 3-bromomethyl-benzofuran-2-carboxylic acid ethyl ester (designated: MCC1019) as selective PLK1 inhibitor targeting PLK1 PBD. Cytotoxicity and fluorescence polarization-based screening were applied to a library of 1162 drug-like compounds to identify potential inhibitors of PLK1 PBD. The activity of compound MC1019 against the PLK1…

PRP in the treatment of Achilles tendinopaty

2013

VALUTAZIONE DELL'EFFICACIA DELL'INFILTRAZIONE ECO-GUIDATA DEL PRP (PLATELET RICH PLASMA) SULL’OUT-COME DEI PAZIENTI CON DOLORE E LIMITAZIONE FUNZIONA…

Trattamento con PRP (platelet rich plasma) nelle tendinopatie dell'arto inferiore. Nostra esperienza.

2011

Reconstruction of the internal structure of the pore system of a complex dinosaur eggshell (Megaloolithus siruguei)

2013

Despite the many reconstructions of fossil material that have recently appeared in the literature, dinosaur eggshells have never been reconstructed using computing techniques. Using the EMAC 3-D modelling methodology, we reconstruct a section of the Late Cretaceous Megaloolithus siruguei eggshell, which has a particularly complex pore system, exhibiting an intricate network of vertical, oblique, and horizontal pores.

Dinosauroid footprints of French Upper Triassic. Discrimination, interpretation and comparison

2005

Abstract Dinosauroid tracks are common in France. They are mainly tridactyl II–IV feet tracks, sometimes with those of hands. A lot of these latter Coelurosaurichnus grancieri Courel & Demathieu, 2000 was discovered by MG near the village of Payzac (Ardèche department) in beds belonging to the “Ensemble gréso-dolomitique gris” (= EGDG) (fig. 1. 2). They are dated Carnian from palynological data [Fauconnier et al., 1996]. C. grancieri are tracks of feet and hands respectively 10 cm and 2.5 cm long (fig. 1. 3–5, 7–21; tabl. I-1, tabl. II). From the trackways characters, it was inferred that trackmakers were long legged, bipedal-quadrupedal reptiles, 1–2 m long. New discoveries made by M…

Palynological variations and sedimentary cycles in the Jurassic from the Paris basin

1995

Abstract Two studies, one on Hettangian dolomitic cap rocks over “Gaz de France” gas storage reservoir rocks at Sologne, and the other on two separate sections in Dogger formations in Burgundy, conducted at the Palynology Laboratory of Strasbourg, illustrate that a palynological approach can lead to a considerable refinement of knowledge in sequence stratigraphy. The palynological study of the dolomitic cap rocks at Sologne dates them as Hettangian, distinguishes microfloristical assemblage types within the sequence, and establishes palynofacies variations with basin evolution. The evidence suggests that palynological variations in the Hettangian rocks are attenuated, reflecting restricted …

Lung myofibroblasts are characterized by down-regulated cyclooxygenase-2 and its main metabolite, prostaglandin E2.

2013

Background: Prostaglandin E2 (PGE(2)), the main metabolite of cyclooxygenase (COX), is a well-known anti-fibrotic agent. Moreover, myofibroblasts expressing alpha-smooth muscle actin (alpha-SMA), fibroblast expansion and epithelial-mesenchymal transition (EMT) are critical to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Our aim was to investigate the expression of COX-2 and PGE(2) in human lung myofibroblasts and establish whether fibroblast-myofibroblast transition (FMT) and EMT are associated with COX-2 and PGE(2) down-regulation. Methods: Fibroblasts obtained from IPF patients (n = 6) and patients undergoing spontaneous pneumothorax (control, n = 6) and alveolar epithelial ce…