Search results for "Dino"

Tissue reaction to sealing materials: different view at biocompatibility

2010

Abstract The biodegradability of root canal sealers in areas other than the root canal system is crucial to the overall success rate of endodontic treatment. The aim of the present study was to investigate, the cell and tissue reaction to GuttaFlow and AHPlus, both in vitro and in vivo. For the in vitro experiments the materials were incubated with Human Periodontal Ligament Fibroblasts and cell proliferation and cytotoxicity analyses were performed. Additional fluorescence-microscope stainings were carried out in order to visualize cell growth and morphology. For assessment of the tissue reaction to the materials a subcutaneous implantation model in Wistar rats was employed and the inflamm…

Extracellular calcium-sensing receptor mediates human bronchial epithelial wound repair

2010

The airway epithelium routinely undergoes damage that requires repair to restore epithelial barrier integrity. Cell migration followed by proliferation are necessary steps to achieve epithelial repair. Calcium-sensing receptor (CaSR) is implicated in cell migration and proliferation processes. Thus we hypothesized that CaSR mediates lung epithelial wound repair. We detected CaSR expression in human lung and in well-differentiated human bronchial epithelial cells (HBEC). To test the CaSR functionality, HBEC loaded with fura-2 were stimulated with extracellular Ca(2+) ([Ca(2+)](out)) which resulted in a concentration-dependent intracellular Ca(2+) ([Ca(2+)](i)) increase (potency approximately…

Evaluation of alprazolam-induced behavioural effects: differences with chlordiazepoxide after interaction with desipramine and rolipram, a cAMP phosp…

1989

Head-twitch and forepaw-shake responses after single and repeated treatment with rolipram: interaction with noradrenergic and dopaminergic agonists a…

1988

Cardiovascular effects induced by rolipram, a selective cAMP phosphodiesterase inhibitor: Interaction with adrenergic and calcium affecting drugs

1990

H2-antihistaminics. 20. Structure-activity relationships in H2-receptor antagonists containing a 4-pyrimidone moiety.

1984

In a series of 5,6-substituted 4- pyrimidones 1 a-v the H2-antihistaminic activity was determined (guinea-pig atrium) and lipophilicity data are given in form of Rmo -values. The influence of different substituents at position 5 or 6 of a pyrimidone moiety has been studied. Quantitative structure-activity analyses showed the importance of lipophilicity for drug activity. Additionally other physicochemical substituent-properties may play a major role.

Dinoflagellates from marine algal blooms produce neurotoxic compounds: effects on free calcium levels in neuronal cells and synaptosomes

2000

In this report, evidence is presented that the marine unicellular eukaryotic dinoflagellates can cause neurotoxicity very likely by an increase in intracellular free calcium ions ([Ca(2+)](i)). Determinations of the effects of culture supernatants from different clones of the dinoflagellate Alexandrium sp. isolated from algal blooms on the viability of rat primary neuronal cells revealed that all clones tested were toxic for these cells. In addition, all Alexandrium clones tested, except for A. ostenfeldii BAH ME-141, were found to be toxic for rat pheochromocytoma PC12 cells. No toxicity was observed for culture supernatants from Gonyaulax and Coolia monotis. Calcium ions are important in …

The Molecular Analysis of the Light Adaptation Reactions in the Yellow‐green Alga Pleurochloris meiringensis (Xanthophyceae)

1988

The xanthophycean alga Pleurochloris meiringensis was homocontinuously cultured under high light (16 W/m2) and low light (2 W/m2) conditions. In low light cells, the chlorophyll a content and the dry weight on per cell basis is increased, the maximal photosynthetic capacity per chlorophyll is decreased. The content of chlorophyll c, vaucheriaxanthin-ester and heteroxanthin is similar in both cultures, whereas the content of diadinoxanthin and s-carotene is twice as high in high light cultures. High light cells contain more photosystem I and cytochrome f per chlorophyll than low light cells, whereas the QB content is found to be unchanged. Therefore, the ratio reaction center II/reaction cen…

Protective effect of apocynin in a mouse model of chemically-induced colitis.

2013

Apocynin, a constituent of Picrorhiza kurroa, successfully inhibits NADPH oxidase and shows promise as an anti-inflammatory drug. Now, we report anti-inflammatory effects of apocynin in an experimental colitis model induced by dextran sulfate sodium as well as the effects on the mediators involved in this process. Apocynin reduced the colitis induced in mice by administration of 5 % dextran sulfate sodium during 7 days. Mice were fed a control diet or a diet supplemented with 2 % of apocynin or 2 % of rutin. Sulfasalazine (50 mg/kg, p. o.) was used as a positive control. Treatment with apocynin and rutin ameliorated the course of colonic inflammation with results similar to those of the ref…

Lo spazio del potere civile e religioso nella Palermo normanna. S. Maria dell'Ammiraglio, S. Maria del Cancelliere, S. Maria Nuova o dei Marturano

2009

L'A. affronta lo studio dei poli urbani del potere in epoca normanna, in particolare quello del grande emiro Giorgio di Antiochia, ove sorge la Chiesa di Santa Maria, detta dell'Ammiraglio, di rito greco, e quello del gran cancelliere Matteo di Salerno, ove fonda il monastero di Santa Maria de Latinis o del Cancelliere, in relazione alla configurazione storica della città ed alle trasformazioni cui va incontro.