Search results for "Diols"
showing 10 items of 10 documents
Efficacy of mometasone furoate microemulsion in the treatment of erosive-ulcerative oral lichen planus: pilot study
2004
Background: Oral lichen planus (OLP) is a frequent immunological chronic disease, having different clinical forms: asymptomatic and symptomatic. Symptomatic OLP has been palliated with topical corticosteroids with different levels of efficacy and safety. The purpose of this pilot phase II clinical trial was to determine the efficacy of mometasone furoate microemulsion upon the symptoms and signs of erosive-ulcerative OLP. Methods: Forty-nine patients with clinical and histologically confirmed erosive-ulcerative OLP were enrolled in this study (36 women and 13 men). Their average age was 56.4 years (from 28 to 78). The treatment consisted of 0.1% mometasone furoate microemulsion mouthwash …
Diastereoselective Synthesis of 2-Phenylselenenyl-1,3-anti-Diols and 2-Phenylselenenyl-1,3-anti-Azido-Alcohols via Hydroxy- and Azido-Selenenylation …
2005
A method to synthesize 2-phenylselenenyl-1,3-anti-diols and 2-phenyl- selenenyl-1,3-anti-azidoalcohols via hydroxy- or azido-selenenylation of trans-allylic alcohols is reported. Moreover, the first example of hydroxyl-selenenylation of an allylic azide is presented. Yields ranging from moderate to good and diastereomeric ratios up to 95:5 are achieved.
Farmaceitisko savienojumu noteikšana apkārtējās vides paraugos ar augstas izšķirtspējas masspektrometrijas metodēm
2016
Farmaceitisko savienojumu noteikšana apkārtējās vides paraugos ar augstas izšķirtspējas masspektrometrijas metodēm. Pērkons I., zinātniskie vadītāji: Dr. ķīm., asoc. prof. Bartkevičs V., Dr. ķīm. Začs Dz.. Maģistra darbs, 51 lappuse, 16 attēli, 16 tabulas, 54 literatūras avoti, 1 pielikums. Latviešu valodā. Darbā tika izstrādāta jutīga UHPLC-Q-Orbitrap-HRMS metode divdesmit četru plaša diapazona farmaceitisko savienojumu noteikšanai ūdens paraugos. Papildus tika izstrādāta selektīva GC-HRMS metode steroīdo estrogēnu, 17β-estradiola un 17α-etenilestradiola, noteikšanai, kurai paralēli tika veikts salīdzinājums ar identisku GC-MS2 metodi. Izstrādātās metodes tika optimizētas, validētas un vei…
NOTCH, a new signaling pathway implicated in holoprosencephaly.
2011
International audience; Genetics of Holoprosencephaly (HPE), a congenital malformation of the developing human forebrain, is due to multiple genetic defects. Most genes that have been implicated in HPE belong to the sonic hedgehog signaling pathway. Here we describe a new candidate gene isolated from array comparative genomic hybridization redundant 6qter deletions, DELTA Like 1 (DLL1), which is a ligand of NOTCH. We show that DLL1 is co-expressed in the developing chick forebrain with Fgf8. By treating chick embryos with a pharmacological inhibitor, we demonstrate that DLL1 interacts with FGF signaling pathway. Moreover, a mutation analysis of DLL1 in HPE patients revealed a three-nucleoti…
Stereoselective synthesis and application of tridentate aminodiols derived from (+)-pulegone
2016
Abstract A library of tridentate aminodiols, derived from naturally occurring (R)-(+)-pulegone, was synthesized and applied as chiral catalysts in the addition of diethylzinc to benzaldehyde. The reduction of pulegone furnished pulegol, which was transformed into allylic trichloroacetamide via Overman rearrangement of the corresponding trichloroacetimidate. The protected enamine was subjected to dihydroxylation with OsO4/NMO system resulting in a 1:1 mixture of (1R,2R,4R)- and (1S,2S,4R)-aminodiol diastereomers. After the removal of the trichloroacetyl protecting groups, the obtained primary aminodiols were transformed into secondary ones. The regioselectivity of the ring closure of the N-b…
Nanoencapsulation in Lipid-Core Nanocapsules Controls Mometasone Furoate Skin Permeability Rate and Its Penetration to the Deeper Skin Layers
2013
<b><i>Aims:</i></b> The influence of nanoencapsulation of mometasone furoate (MF) in poly(ε-caprolactone) lipid-core nanocapsules (LNC) on its in vitro human skin permeation and penetration was evaluated. <b><i>Methods:</i></b> Semisolid formulations were prepared by increasing the viscosity of LNC using a carbomer (Carbopol® Ultrez at 0.5% w/v). Two complementary techniques (the static Franz diffusion cell model and the Saarbrücken penetration model) were used to evaluate skin permeation/penetration. <b><i>Results:</i></b> The drug release rate was decreased by nanoencapsulation. The skin permeability of MF was control…
Studies on the Stereoselective Selenolactonization, Hydroxy and Methoxy Selenenylation of α- and β-Hydroxy Acids and Esters. Synthesis of δ- and γ-La…
2003
Abstract The diastereoselective synthesis of hydroxy substituted γ- and δ-lactones was accomplished following two approaches. A 5- or 6-endo cyclization promoted by electrophilic selenium reagents of α- or β-hydroxy acids and a 5- or 6-exo cyclization of hydroxy esters obtained through a diastereoselective hydroxy selenenylation reaction of α- or β-hydroxy esters. Moreover, the diastereoselective methoxy selenenylation of the above compounds was investigated showing a case in which the compound that was unreactive in the hydroxy selenenylation conditions gave, in the methoxy selenenylation conditions, the deprotected diol. The usefulness of the methoxy selenenylation procedure was proven by…
Latvijā legālie kaņepju preparāti un to izmantošana Latvijas iedzīvotāju vidū
2022
Kaņepju preparāti ir gan vēsturiski, gan mūsdienās aktuāls līdzeklis, ko izmanto gan skaistumkopšanā, gan medicīniskiem nolūkiem, gan arī uzturā. Tie kļuvuši īpaši populāri kā uztura bagātinātāji ikdienas dzīvēs cilvēkiem, lai uzlabotu dzīves kvalitāti, papildinot uzturu ar vērtīgajām vielām, ko satur kaņepes. Kanabinoīdi no kaņepju auga uz organismu iedarbojas caur endokanabinoīdu sistēmu. Pētījuma mērķis ir apkopot datus par Latvijas iedzīvotāju informētību par legālajiem kaņepju preparātiem un par parametriem, kas saistīti ar šo preparātu lietošanu. Rezultāti liecina, ka arī starp Latvijas iedzīvotajiem kaņepju preparāti ir zināmi un tiek izmantoti dažādiem potenciāliem ieguvumiem, kurie…
Kaņepju auga iegūšanas, izplatīšanas, izmantošanas uzturā un medicīniskiem nolūkiem - tiesiskais regulējums Eiropas Savienībā, starptautiskajās tiesī…
2020
Kaņepju augu šķiedra, sēklas, ziedi un lapas jau tūkstošiem gadu ir tikušas izmantotas gan dažādu sadzīves, gan pārtikas produktu pagatavošanai, kā arī medicīniskiem un atpūtas nolūkiem, tomēr daudzu politisku iemeslu dēļ 20.gs vidū daudzviet pasaulē šī auga izmantošana tika aizliegta, jo kaņepju sastāvā tika atklāta viela tetrahidrokanabinols, kas ir psihoaktīva un atkarību izraisoša viela. Turklāt 20.gs. 60.gados kaņepju izmantošanas aizliegumu sāka noteikt starptautiskā līmenī, tomēr vēlāk kaņepes atļāva audzēt šķiedras un sēklu ieguvei, kā arī dārzkopības mērķiem. Neraugoties uz pastāvošajiem ierobežojumiem, interese par kaņepju augiem sabiedrībā nav zudusi, tieši pretēji – palielinājus…
Evolving European guidance on the medical management of neovascular age related macular degeneration
2006
BACKGROUND: Until recently, only two options were available for the treatment of choroidal neovascularisation (CNV) associated with age related macular degeneration (AMD)-thermal laser photocoagulation and photodynamic therapy with verteporfin (PDT-V). However, new treatments for CNV are in development, and data from phase III clinical trials of some of these pharmacological interventions are now available. In light of these new data, expert guidance is required to enable retina specialists with expertise in the management of AMD to select and use the most appropriate therapies for the treatment of neovascular AMD. METHODS: Consensus from a round table of European retina specialists was obt…