Search results for "Dios"

Erythropoietin restores the anemia-induced reduction in radiosensitivity of experimental human tumors in nude mice

2003

Abstract Purpose The effect of recombinant human erythropoietin (rhEPO) on the radiosensitivity of human tumor xenografts growing in anemic and nonanemic nude mice was studied. Methods and materials Anemia was induced by total body irradiation ([TBI], 2 × 4 Gy) of mice before tumor implantation into the subcutis of the hind leg. The development of anemia was prevented by rhEPO (750 U/kg s.c.) given 3 times weekly starting 2 weeks before TBI. Fourteen days after fractionated TBI (tumor volume of approx. 40 mm 3 ), single-dose irradiation of the tumor with varying doses was performed so that in full dose–response relationship for the probability of tumor cure was obtained. Results Radiation-i…

In Regard to Chung et al

2015

Growth rates or radiobiological hypoxia are not correlated with local metabolite content in human melanoma xenografts with similar vascular network.

1995

Investigations were carried out on two lines of human melanomas (MF; n = 12 and EE; n = 13) xenografted in nude mice. The tumours were characterised by a similar vascular supply but showed a pronounced difference in the rate of volume growth and in the radiobiologically hypoxic fraction. The distribution of ATP, glucose and lactate in the tumours was investigated using quantitative bioluminescence and single photon imaging. Concentrations of the metabolites were obtained as global values for the entire tumour mass, in regions with densely packed, structurally intact tumour cells ('viable zones'), in areas with necrosis, stromal cells and fibrous material ('necrotic zones') and in adjacent n…

Pharmacogenomics of Cameroonian traditional herbal medicine for cancer therapy

2011

Abstract Ethnopharmacological relevance A socio-economic burden associated with cancers is reported in Africa. Ethnopharmacological usages such as immune and skin disorders, inflammatory, and others chould be considered when selecting plants used to treat cancer, since these reflect disease states bearing relevance to cancer or a cancer symptoms. Materials and methods Documented compounds of Cameroonian medicinal plants were used as keywords in the National Cancer Institute (NCI) database to establish a library of cytotoxic compounds. Cellular and pharmacogenomic profiling was then performed for the 10 most cytotoxic natural products. By COMPARE and hierarchical cluster analyses, candidate …

Más allá del voto

2007

Surface to boundary layer coupling in the urban area of Lisbon comparing different urban canopy models in WRF

2019

Abstract This work presents a sensitivity study to evaluate different Urban Canopy Models (UCM) existing within the Weather Research and Forecasting Model (WRF) in the urban area of Lisbon, Portugal. Several hind-cast simulations were carried out for a selected period in July 2010, in which synoptic conditions favoured urban heat island formation. We aim to gain knowledge on the feedback of modified urban canopy representation in WRF on local scale meteorology and the boundary-layer dynamics over the urban area, by comparing a single layer urban canopy model (SLUCM) and a more sophisticated multi-layer building effect parametrisation (BEP). We find significant differences in the characteris…

Por qué a Deivid le gusta Madonna. Imágenes de una "star" entre clásica y moderna

2004

Este artículo es una breve meditación sobre el nacimiento y el posterior desarrollo de una de las más importantes formas de comunicación visual de finales del siglo XX, el vídeo musical pop, y su consiguiente explotación por Madonna. La cantante estadounidense ha reciclado las iconografías clásicas del siglo XX para ofrecer en sus vídeos e imágenes promocionales un envoltorio artístico a su carrera musical dirigida a la sociedad de consumo y de los grandes medios de comunicación. (A)

Una propuesta sobre enseñanza de la relatividad en el bachillerato como motivación para el aprendizaje de la física

2007

Relativity is a very important part of modern physics. In this paper we analyze the teaching and learning of the theory of relativity in secondary education and we show some reasoned arguments against traditional methods to teach it. Finally, a didactic proposal for the teaching of relativity is presented; it comes as a conclusion that it is possible a suitable teaching of the principles of relative which should bring into the students a change in attitude, concepts and methodology.

El héroe mediático

2005

Natural Course, Clinical Profile, and Treatment Strategies for Cerebral Cavernous Malformations

2022

A large body of evidence has suggested that the natural biology for symptomatic cerebral cavernous malformations (CCMs) is dynamic. These lesions exhibit a temporal clustering epiphenomenon and usually manifest with multispectral clinical patterns, the most relevant being hemorrhagic and seizurogenic events. Most patients with cerebral cavernous malformations are asymptomatic, and the lesions are detected as incidentalomas. However, association with the CCM3 gene, Zabramski type I and II lesions, and brainstem location have the propensity to increase the bleeding events. The rebleeding risk is 20%/year per lesion, which supports the need for surgical strategies for brainstem cavernous malfo…