Search results for "Dios"
showing 10 items of 1322 documents
GTVcut for neuro-radiosurgery treatment planning: an MRI brain cancer seeded image segmentation method based on a cellular automata model
2018
Despite of the development of advanced segmentation techniques, achieving accurate and reproducible gross tumor volume (GTV) segmentation results is still an important challenge in neuro-radiosurgery. Nowadays, magnetic resonance imaging (MRI) is the most prominent modality in radiation therapy for soft-tissue anatomical districts. Gamma Knife stereotactic neuro-radiosurgery is a minimally invasive technology for dealing with inaccessible or insufficiently treated tumors with traditional surgery or radiotherapy. During a treatment planning phase, the GTV is generally contoured by experienced neurosurgeons and radiation oncologists using fully manual segmentation procedures on MR images. Unf…
Europa marcha atrás / 1. El malentendido de la ampliación
2004
Bomberos pirómanos (1)
2008
Two-step radiosynthesis of [18F]FE-β-CIT and [18F]PR04.MZ
2013
The cocaine-derived dopamine reuptake inhibitors FE-β-CIT (8-(2-fluoroethyl)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester) (1) and PR04.MZ(8-(4-fluorobut-2-ynyl)-3-p-tolyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester) (2) were labelled with (18)F-fluorine using a two-step route. 2-[(18)F]Fluoroethyltosylate and 4-[(18)F]fluorobut-2-yne-1-yl tosylate were used as labelling reagents, respectively. Radiochemically pure (>98%) [(18)F]FE-β-CIT and [(18)F]PRD04.MZ (32-86 GBq/µmol) were obtained after a synthesis time of 100 min in about 25% non-decay-corrected overall yield.
Synthesis and radiosynthesis of N5-[18F]fluoroethyl-Pirenzepine and its metabolite N5-[18F]fluoroethyl-LS 75
2009
The well established M1 selective muscarinergic antagonist Pirenzepine 11-[2-(4-methyl-piperazin-1-yl)-acetyl]-5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one (1) exhibits an unusual behaviour in vivo, which cannot be explained with M1 antagonism exclusively. One of the aspects discussed is a specific interaction with poly ADP-ribose polymerase (PARP-1). 1 undergoes metabolism to form LS 75 5,11-dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one (2). In order to study deviations in Pirenzepine efficacy from pure M1 binding in vivo using PET, appropriate positron emitter labelled analogues of 1 and 2 were synthesised. Non-radioactive reference compounds 3 and 4 were tested for PARP-1 inh…
Binding and activation of human and mouse complement by Cryptosporidium parvum (Apicomplexa) and susceptibility of C1q- and MBL-deficient mice to inf…
2008
Cryptosporidium parvum is a protozoan parasite (Apicomplexa) that causes gastrointestinal disease in animals and humans. Whereas immunocompetent hosts can limit the infection within 1 or 2 weeks, immunocompromised individuals develop a chronic, life-threatening disease. The importance of the adaptive cellular immune response, with CD4+ T-lymphocytes being the major players, has been clearly demonstrated. Several non-adaptive immune mechanisms have been suggested to contribute to the host defence, such as interferon-gamma (IFN-gamma) from NK cells, certain chemokines, beta-defensins and pro-inflammatory cytokines, but the influence of the complement systems has been less well studied. We ana…
La destitución del mito. Christa Wolf y la reescritura de la memoria histórica
2018
En este ensayo se reconstruye el recorrido narrativo de Christa Wolf desde una perspectiva que propongo definir como destitución mitológica. Se fijan cuatro estaciones correspondientes con las cuatro novelas cruciales en la biografía literaria de la autora. La primera es El cielo partido, en la que Wolf trabaja con el concepto de Vergangenheitsbewältigung, es decir: una elaboración del pasado que permite su superación. La segunda es Muestra de infancia, en la que aparece la figura de la precisión fantástica, entendida como la única auténtica posibilidad de memoria histórica colectiva. Finalmente Casandra y Medea, donde este trabajo de rememoración encuentra su aplicación en la deconstrucció…
Los cibermedios valencianos : Cartografía, características y contenidos
2008
167 p.
Trails and Vestiges in the Stories and Travels of Eduardo L. Holmberg venezolano
2010
Este trabajo pretende estudiar la narrativa breve de Eduardo Holmberg, la manera cómo el escritor argentino traza, mediante acotaciones metaliterarias sobre los procesos constructivos del relato, fantasías científi cas y juguetes policiales desde una conciencia fi ccional que asume el estatuto literario como artifi cio y simulación. No sólo en este pliegue metafi ccional se funda el orden fantástico de las fábulas de este escritor, pues de una u otra manera, ese orden se nutre de los juegos alrededor del paradigma de la representación, del poder del simulacro, la pérdida del control narrativo y la posibilidad de una refl exión sobre el límite de la ficción. This paper is an analysis of the …