Search results for "Direct"
showing 10 items of 2669 documents
Gastrointestinal disorders and dabigatran.
2012
Anticoagulants play an important role in the prevention and treatment of a variety of acute and chronic thromboembolic disorders such as primary prevention and treatment of venous thromboembolism or prevention of stroke and systemic embolism in atrial fibrillation just to name of few. Within recent years, a promising new oral anticoagulant, the direct thrombin inhibitor dabigatran etexilate (dabigatran) successfully underwent clinical development and has emerged as an alternative to vitamin K antagonists according to a variety of recently revised and updated international guidelines referring to the indication of stroke prevention in atrial fibrillation. Considering the intensive clinical u…
Directly measured and self-reported physical activity in a sample of Finnish secondary school students
2012
Previous studies based on self-reports show that a majority of children and adolescents in Western countries fail to achieve the recommendation of 60 minutes moderate to vigorous physical activity (PA) on a daily basis. The specific aim of the study was to analyze the relationship between directly measured and self-reported PA in a cross-sectional sample of Finnish secondary school students. Moreover, how large proportion of adolescents accumulate at least 60 minutes of moderate to vigorous PA on a daily basis using self-reports and direct measure scores. Methods: Participants were recruited from a secondary school located in Northeast Finland. The sample comprised 96 students (58 girls, 38…
Directional Control Mechanisms in Multidirectional Step Initiating Tasks.
2020
Typical anticipatory postural adjustments (APAs) in forward gait or step initiation tasks to prepare for possible disturbances caused by prime voluntary movements and to accelerate the body forward have been previously reported. However, it is not clear how wide the variations in step directions are differentiated and controlled in non-forward step initiation tasks during the APA phase. The main goal of this study is to explain the directional control mechanisms by investigating the APA of step initiation tasks in forward, diagonal, lateral, and posterior directions. The center of pressure (COP) trajectories and related muscle (soleus, tibialis anterior, and gluteus medius of both lower lim…
Cost-effectiveness analysis of statins in primary care: results from the Arteris cohort study.
2021
BACKGROUND The Swiss Federal Office of Public Health performed a health technology assessment regarding statins in primary care. The chosen models may lead to a situation where a clinically indicated statin therapy is estimated not to be cost effective. METHODS We performed a cohort study regarding cardiovascular events, comparing SCORE and AGLA risk categories with tertiles of carotid plaque burden and used two models for cost-effectiveness analysis of high-potency statins. RESULTS Subjects (n = 2842) were followed up for 5.9 ± 2.9 years with the occurrence of 154 cardiovascular events (extrapolated 10-year risk was 9.2%). Carotid plaque imaging (total plaque area, TPA) significantly impro…
Transcranial Direct Current Stimulation over the Right Inferior Parietal Cortex Reduces Transposition Errors in a Syllabic Reordering Task
2021
Evidence derived from functional imaging and brain-lesion studies has shown a strong left lateralization for language, and a complementary right hemisphere dominance for visuospatial abilities. Nevertheless, the symmetrical functional division of the two hemispheres gives no reason for the complexity of the cognitive operations involved in carrying out a linguistic task. In fact, a growing number of neuroimaging and neurostimulation studies suggest a possible right hemisphere involvement in language processing. The objective of this work was to verify the contribution of the left and right parietal areas in a phonological task. We applied anodal transcranial direct current stimulation (tDCS…
Effect of Different Display Types on Vection and Its Interaction With Motion Direction and Field Dependence
2017
Illusory self-motion (vection) can be generated by visual stimulation. The purpose of the present study was to compare behavioral vection measures including intensity ratings, duration, and onset time across different visual display types. Participants were exposed to a pattern of alternating black-and-white horizontal or vertical bars that moved either in vertical or horizontal direction, respectively. Stimuli were presented on four types of displays in randomized order: (a) large field of view dome projection, (b) combination of three computer screens, (c) single computer screen, (d) large field of view flat projection screen. A Computer Rod and Frame Test was used to measure field depen…
MRI of Pulmonary Ventilation
2008
Gas imaging has opened the new field of direct imaging of pulmonary ventilation by MRI. The use of hyperpolarised 3He gas for MRI of the lung has been pioneered by a number of groups worldwide. Due to the enormous progress in the fields of hyperpolarisation technology, administration of hyperpolarised 3He, MR hardware, and MR pulse sequences significant progress has been made and the translation into the clinical arena has been accomplished. This chapter gives an overview of the technical methods for HP 3He MRI for human lung imaging, focusing on gas polarisation methods, background physics, MRI hardware considerations, MRI pulse sequence considerations, safety considerations for imaging in…
Tutorial in oral antithrombotic therapy: biology and dental implications.
2013
Objectives: Recent developments of new direct oral anticoagulants that target specific clotting factors necessitate understanding of coagulation biology. The objective of this tutorial is to offer dental professionals a review of coagulation mechanisms and the pharmacodynamics of the conventional and new oral anticoagulants. Also, we summarized the dental implications of the conventional and new anticoagulants. Method: We searched Medline using search terms “antithrombotic”, “antihemostasis” or “anticoagulation” and combined them with the search results of “dental”, “oral surgery” or “periodontal”. We restricted the results to “human” and “English”. Results: The early coagulation cascade, t…
Association of transcatheter direct mitral annuloplasty with acute anatomic, haemodynamic, and clinical outcomes in severe mitral valve regurgitation.
2020
Abstract Aims Several approaches for transcatheter mitral valve repair for functional mitral valve regurgitation are established. Interventional direct annuloplasty is a novel trans‐venous, trans‐septal approach. While feasibility was proven recently, knowledge on its influence on cardiac dimensions, pressures, biomarkers, and clinical outcomes is sparse. Methods and results Patients consecutively treated with direct annuloplasty‐only procedures between December 2015 and April 2018 were included in this monocentric analysis. Echocardiographic measurements, biomarker levels, clinical status [New York Heart Association (NYHA) class and 6 min walk test] were assessed at baseline, at discharge,…
Combined Behavioral and Mismatch Negativity Evidence for the Effects of Long-Lasting High-Definition tDCS in Disorders of Consciousness: A Pilot Study
2020
Objective: To evaluate the effects of long-term High-definition transcranial direct current stimulation (HD-tDCS) over precuneus on the level of consciousness (LOC) and the relationship between Mismatch negativity (MMN) and the LOC over the therapy period in patients with Disorders of consciousness (DOCs). Methods: We employed a with-in group repeated measures design with an anode HD-tDCS protocol (2 mA, 20 min, the precuneus) on 11 (2 vegetative state and nine minimally conscious state) patients with DOCs. MMN and Coma Recovery Scale-Revised (CRS-R) scores were measured at four time points: before the treatment of HD-tDCS (T0), after a single session of HD-tDCS (T1), after the treatment of…