Search results for "Disc"
showing 10 items of 19256 documents
Molecular Modelling Studies on Molecular Pathways Related to Tumorigenesis in the Discovery of New Lead Compounds.
2012
Luci e ombre delle modifiche alla disciplina della tutela cautelare
2023
La tutela cautelare nel processo tributario e` stata oggetto di ripetuti interventi di riforma, determinati sia dall’opportunita` di disciplinarne l’accesso anche nei giudizi di impugnazione, sia dalla necessita` di meglio bilanciare la posizione del contribuente a fronte della significativa accelerazione impressa dal legislatore all’esecuzione forzata. L’esame del contenuto e dei limiti della nuova disciplina consente di apprezzare la scelta di riservare norme specifiche alla tutela inibitoria nei gradi di giudizio successivi al primo e di ridurre la discrezionalita` del giudice nel concedere la tutela condizionata. Al contempo, l’indagine lascia emergere l’opportunita` di un nuovo ripensa…
1919-2019: ritorno all’entropia Un progetto pilota practice-oriented per una formazione transdisciplinare del designer
2020
In un articolo pubblicato da Domus nel 1998 John Thackara sosteneva che il destino del design sarebbe stato l’entropia, presentando possibili e stimolanti vie di fuga da tale dimensione. A 20 anni da questa affermazione e a 100 anni dal Bauhaus, si avverte la necessità di immaginare un’offerta formativa altrettanto visionaria e coraggiosa come quella di Weimar, in grado di assumere l’entropia descritta da Thackara in una nuova prospettiva. Se il progetto culturale di Gropius metteva al centro la trasversalità fra ambiti e saperi diversi, oggi occorre dare una nuova interpretazione a questo atto fondativo, in termini altrettanto ambiziosi, a partire da alcuni interrogativi: che sembianze ass…
Recursion at the crossroads of sequence modeling, random trees, stochastic algorithms and martingales
2013
This monograph synthesizes several studies spanning from dynamical systems in the statistical analysis of sequences, to analysis of algorithms in random trees and discrete stochastic processes. These works find applications in various fields ranging from biological sequences to linear regression models, branching processes, through functional statistics and estimates of risk indicators for insurances. All the established results use, in one way or another, the recursive property of the structure under study, by highlighting invariants such as martingales, which are at the heart of this monograph, as tools as well as objects of study.
Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening.
2015
In drug discovery the reliable prediction of binding free energies is of crucial importance. Methods that combine molecular mechanics force fields with continuum solvent models have become popular because of their high accuracy and relatively good computational efficiency. In this research we studied the performance of molecular mechanics generalized Born surface area (MM-GBSA), molecular mechanics Poisson-Boltzmann surface area (MM-PBSA), and solvated interaction energy (SIE) both in their virtual screening efficiency and their ability to predict experimentally determined binding affinities for five different protein targets. The protein-ligand complexes were derived with two different app…
Suitability of MMGBSA for the selection of correct ligand binding modes from docking results
2019
The estimation of the correct binding mode and affinity of a ligand into a target protein using computational methods is challenging. However, docking can introduce poses from which the correct binding mode could be identified using other methods. Here, we analyzed the reliability of binding energy estimation using the molecular mechanics‐generalized Born surface area (MMGBSA) method without and with energy minimization to identify the likely ligand binding modes within docking results. MMGBSA workflow (a) outperformed docking in recognizing the correct binding modes of androgen receptor ligands and (b) improved the correlation coefficient of computational and experimental results of rescor…
Sediment quality of the ecoregion Engure, Gulf of Riga, assessed by using ecotoxicity tests and biomarker responses
2014
Pētījuma mērķis bija novērtēt Engures ekoreģiona (Rīgas līča rietumu piekrastes) sedimentu kvalitāti, izmantojot sedimentu ekotoksicitātes testus. Lai noteiktu bioloģiskās atbildes reakcijas uz dažāda veida stresoriem, kā testorganismi pielietotas sānpeldes Monoporeia affinis and Pontogammarus robustoides, un izvēlēti biomarķieri (AChE, GST, GR, CAT, MT), kas noteikti gliemenēs Macoma balthica. Engures ekoreģionu varētu uzskatīt par nepiesārņotu rajonu, jo tā sedimentus raksturo salīdzinoši zemas smago metālu koncentrācijas. Engures ekoreģiona sedimentu ekotoksicitātes testu rezultāti neuzrādīja statistiski būtisku (>20% mirstība) toksisko efektu. Testorganismu izdzīvotība bija robežās no 8…
A Pilot Study on Developing Newsgames in Collaboration between Journalism and Computer Science Students
2019
Abstract Producing digital and interactive journalistic products offers unique and important new learning opportunities for journalism education. This study analysed the experiences of two pilot courses on so-called ‘newsgames’ in a Finnish university in 2015 and 2017. The data consisted of the newsgames and other materials produced by the students, student feedback concerning the course and observations of teachers throughout the project. Our analysis demonstrates how producing newsgames in the context of higher education may foster project-based learning experiences, something that has been relatively rare in traditional journalism education. Collaboration with media companies also offere…
Conceptualizing the role of multidisciplinarity and student perceptions of university-industry collaboration in project-based learning
2017
Project-based learning has a long history, especially in the disciplines of computer science and engineering. This approach is used to offer students a realistic view of their discipline, and this experience can be enhanced with industrial involvement as companies bring their real world problems to projects. One recent trend in project-based learning is utilizing multidisciplinary teams, enabling students to contrast their skills and experience with students from other disciplines. This thesis focuses on a project course involving multidisciplinary teams and real customers that has been organized at the University of Jyväskylä since 2011 focused on developing students’ general working life …
Introduction to next-generation engineering: Being human in the information society
2022
While adopting Information Technology (IT) may have been a goal in itself in the past, during the last decade the emphasis has shifted, and IT has instead become a tool that enables us to realize other needs. This also sets new requirements for IT education: skills in software engineering and computer science alone do not provide students with the professional abilities they will need after graduation. To answer this call, the University of Jyväskylä launched in autumn 2021 a new engineering B.Sc. and M.Sc. degree program in Information and Software Engineering with close ties to the Humanities. The degree program was established on three cornerstones: 1) the ability to implement IT systems…