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showing 10 items of 19256 documents
Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors
2012
Herein we report the synthesis of a set of constrained peptidomimetics endowed with an electrophilic vinyl ester warhead and structurally related to a previously identified lead compound, a potent and irreversible inhibitor of falcipain-2 (FP-2). FP-2 is the main hemoglobinase of the malaria parasite P. falciparum. The new compounds were evaluated for their inhibition against FP-2, and the results were rationalized on the basis of docking experiments. These studies underscore the pivotal role of both the ester function at the P1' site and the trifluoromethyl group of the P3 side chain in determining the correct orientation of the Michael acceptor warhead in the catalytic site, and as a cons…
Psychometric properties of the Assessment Tool for Perceived Agency (ATPA-22) - utility for the rehabilitation of young adults not in education, empl…
2020
Background: Promoting and supporting agency have been at the heart of the debate multidisciplinary. To promote self-awareness of young people’s agency and identify persons in need of support the Assessment Tool for Perceived Agency (ATPA-22) was developed. Aim: This study aims to evaluate the psychometric properties of the ATPA-22. Participants were young adults not in education, employment or training (NEETs) and students in higher education (HEI). Materials and methods: The main data analysis was implemented by Many Faceted Rasch (MFR) analysis. Results: The ATPA-22 items defined a unidimensional construct with reasonable internal consistency and separation ability. The ATPA-22 was capabl…
Discapacitat intel·lectual i fenotip conductual: perfil psicopatològic i trastorns de conducta
2012
Es descriu el fenotip conductual (perfil psicopatològic i trastorns del comportament) en la discapacitat intel·lectual.
I linguaggi intermediali di Bruce Nauman
2007
<p>Barriers and enablers to the implementation of perioperative hypothermia prevention practices from the perspectives of the multidisciplinary…
2019
Judy Munday,1,2 Alana Delaforce,1,3 Gillian Forbes,4 Samantha Keogh11School of Nursing and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia; 2Department of Health and Nursing Science, University of Agder, Grimstad, Norway; 3Clinical Governance Unit, Mater Health, South Brisbane, QLD 4101, Australia; 4Department of Clinical, Educational and Health Psychology, UCL Centre for Behaviour Change, London WC1E 6BT, UKPurpose: Inadvertent perioperative hypothermia is a significant problem for surgical patients globally, and is associated with many detrimental side-effects. Despite the availability of rigorously developed internatio…
Paternidade e licença-paternidade no Brasil: uma análise crítica do processo de formulaçao da licença-paternidade na CF/88
2022
En el marco de la igualdad de género y considerando el ámbito privado como un nodo estructural crítico para el logro de esta igualdad, esta tesis tiene como cuestión de investigación analizar los supuestos ideológicos de género que fundamentaron la formulación del permiso de paternidad en la Asamblea Nacional Constituyente y a raíz de eso institucionalizaron la paternidad en Brasil. Para eso partimos de dos ejes conceptuales centrales. El primero establece el marco teórico-metodológico de la investigación y se basa en las premisas ontológicas y epistemológicas del Constructivismo Social. ―Ideas‖ y ―discurso‖ son los conceptos centrales, considerándose las ideas como variables explicativas p…
Las personas con discapacidad como consumidores vulnerables en el comercio electrónico: el problema de la accesibilidad digital
2022
Este trabajo aborda el estudio de la accesibilidad de las personas con discapacidad al comercio electrónico y su especial situación de vulnerabilidad en este ámbito. Toda contratación de consumo comporta siempre la existencia de una parte débil en la relación contractual debido al fenómeno de la asimetría informativa y a la unilateralización de las cláusulas generales que componen los contratos de consumo. Pero cuando el comercio es electrónico, la participación de las personas con discapacidad supone adicionalmente, por un lado, la existencia de problemas de accesibilidad digital o electrónica que reclaman solución (problemas tales que no son solo de adaptabilidad de los equipos electrónic…
Gender differences in theory-based predictors of physical activity in university students with disabilities
2021
Abstract University students with disabilities engage in physical activity to a lesser extent than their able-bodied peers, with women reporting less physical activity than men. The present study aimed to examine gender differences in theory-based predictors of physical activity in this population. Spanish university students with different disabilities (n = 1076) completed measures of the Theory of Planned Behaviour constructs and the reduced Spanish version of the Barriers to Physical Activity Questionnaire for People with Mobility Impairments. Self-efficacy and controllability were significantly lower in women and gender differences on the barriers predicting controllability were obtaine…
Pārliecināšana kā stratēģija politiskās runās
2020
Pārliecināšana ir viena no mijiedarbes procesos bieži lietotajām komunikācijas metodēm. Vēlēšanu kampaņu laikā kandidāti nereti savās runās izmanto retorikas rīkus, lai manipulētu ar savu mērķauditoriju un iegūtu potenciālo vēlētāju atbalstu. Šī darba mērķis ir izpētīt un pamatot, kā retorika un pārliecināšana izpaužas valodas lietojumā. Pētījuma metode ir diskursa analīze. Pētījums veikts divos līmeņos (micro un meta), pamatojoties uz amerikāņu sociologa Ārona Sikurela (Aaron Cicourel) izstrādāto satura un nozīmes analīzes struktūru. Tika analizētas un pētītas piecas prezidenta Trampa runas. Pētījumu rezultāti norādīja uz deklaratīvo un komisīvo runas aktu izmantojumu, lai radītu pragmatis…
Metonymy in Spanish and American parliamentary speeches: Obama’s State of the Union Address versus Rajoy’s State of the Nation Address
2018
This study attempts to analyze the metonymies used in the Economy section of two equivalent parliamentary speeches: the 2015 State of the Union Address in the US and the 2015 State of the Nation Debate in Spain, which belong to two different debate traditions. The present study aims at answering the following research questions:What metonymies do President Obama and Prime Minister Rajoy use in their American and Spanish parliamentary speeches in an attempt to convince the public of economic victory?What are the similarities and differences between the role of metonymy in shaping public opinion about economic recovery in America and Spain in both speeches?To answer these questions, we use th…