Search results for "Disc"
showing 10 items of 19256 documents
Enhancing Metastability by Dissipation and Driving in an Asymmetric Bistable Quantum System.
2018
The stabilizing effect of quantum fluctuations on the escape process and the relaxation dynamics from a quantum metastable state are investigated. Specifically, the quantum dynamics of a multilevel bistable system coupled to a bosonic Ohmic thermal bath in strong dissipation regime is analyzed. The study is performed by a non-perturbative method based on the real-time path integral approach of the Feynman-Vernon influence functional. We consider a strongly asymmetric double well potential with and without a monochromatic external driving, and with an out-of-equilibrium initial condition. In the absence of driving we observe a nonmonotonic behavior of the escape time from the metastable regi…
Valore probatorio della quietanza rilasciata per conto del (con)creditore e nullità del contratto preliminare ex art. 30 co. 2 TU edilizia. Considera…
2016
A poco più di un anno dall’intervento nomofilattico che ha ricondotto a mera analogia legis l’ascrizione alla quietanza di pagamento del regime della confessione stragiudiziale (Cass. Sez. Un., 22 settembre 2014, n. 19888, in I Contratti, 2015, 147 e ss.), la Corte di Cassazione, con la sentenza n. 23128 del 12 novembre 2015 resa dalla Sezione II, è tornata sull’argomento, muovendo però in questo caso da premesse ricostruttive -ed approdando ad esiti - che, a ben vedere, non solo deflettono dal solco dell’autorevole precedente, ma a tal punto esasperano alcune tensioni interne alla tessitura concettuale della fattispecie di cui all’art. 1199 c.c. da mettere capo ad autentici paradossi.
De venta en venta hasta El Quijote. Un viaje europeo por la literatura de Mesón
2007
On these pages travel from the Canterbury Tales to the Quijote going from inn to inn throughout a European literary geography. We stop and lodge in the italian series of novelle (Sacchetti, Bandello), in the Chevalry Poems of the Renaissance (Pulci, Ariosto), in the Sixteenth Century theatre (from Gil Vicente to Lope de Rueda and the Intronati di Siena), in the Comedia Nueva and especially in the comedias de meson de Lope de Vega, in the Elizabethan Theatre (Shakesperare above all), in the Guzmán de Alfarache, in La ilustre fregona (the novel and also the commedy), and so on until the Quijote, where the multiple experience of inns and roads is closely examined. At every stop I reflecton the…
Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors
2011
Radiotherapy (RT) plays a key role in cancer treatment. Although the benefit of ionizing radiation (IR) is well established, some findings raise the possibility that irradiation of the primary tumor not only triggers a killing response but also increases the metastatic potential of surviving tumor cells. Here we addressed the question of whether irradiation of normal cells outside of the primary tumor augments metastasis by stimulating the extravasation of circulating tumor cells. We show that IR exposure of human endothelial cells (EC), tumor cells (TC) or both increases TC-EC adhesion in vitro. IR-stimulated TC-EC adhesion was blocked by the HMG-CoA reductase inhibitor lovastatin. Glycyrr…
Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth
2010
Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases. However, the molecular mechanisms through which NGF regulates cytoskeletal changes and neurite outgrowth are not totally understood. In this work, we identify the Rac1-specific guanine exchange factor (GEF) Tiam1 as a novel mediator of NGF/TrkA-dependent neurite elongation. In particular, we report that knockdown of Tiam1 causes a significant reduction in Rac1 activity and neurite outgrowth induced by NGF. Physical interaction between Tiam1 and active Ras (Ras- GTP), but not tyrosine phosphorylation of Tiam1, plays a central role in Rac1 activation by NGF. In add…
Molecular Mechanisms of the Blockage of Glioblastoma Motility
2021
Glioblastoma (GBM) is the most common and lethal brain tumor. GBM has a remarkable degree of motility and is able to infiltrate the healthy brain. In order to perform a rationale-based drug-repositioning study, we have used known inhibitors of two small Rho GTPases, Rac1 and Cdc42, which are upregulated in GBM and are involved in the signaling processes underlying the orchestration of the cytoskeleton and cellular motility. The selected inhibitors (R-ketorolac and ML141 for Cdc42 and R-ketorolac and EHT 1864 for Rac1) have been successfully employed to reduce the infiltration propensity of GBM in live cell imaging studies. Complementarily, all-atom simulations have elucidated the molecular …
Verdad y racionalidad en Michel Foucault
1990
Este trabajo se propone establecer la teoría de la verdad tal y como ha sido concebida y puesta en práctica por la obra de Michel Foucault. El material bibliográfico utilizado es muy diverso, incluyendo libros y artículos publicados por el propio Foucault, entrevistas revisadas y publicadas con su autorización, entrevistas no revisadas y publicadas tras su muerte, conferencias transcritas estando Foucault en vida, conferencias transcritas después de su muerte, cursos de los que hay transcripción escrita y cursos de los que tan solo existen las grabaciones, textos de los que hay versión original francesa y textos que están solo en lenguas a las que fue traducido el original francés hablado y…
Razzismi, discriminazioni, confinamenti, Convegno Internazionale, Agrigento, 17-18 gennaio 2013
2013
Minoranze migranti
2013
Si affronta la doppia valenza dei nuclei di migranti extracomunitari: popoli in movimento da una parte e minoranze etniche dall'altra. Con conseguenze proprie della doppia valenza: esigenza di integrarsi e bisogno di coltivare la propria identità. The double value of migrant peoples: peoples in migration, by one hand, and ethnic minorities, by the other. With specific consequencies of the double value: to integrate to the majorities and to reaffirm originary identity.
Phenolic Profiles, Antioxidant and Anti-Inflammatory Activities of Hydrodistillation Wastewaters from Five Lamiaceae Species
2022
Distillation is the most widely used method to obtain an essential oil from plant material. The biomass used in the process is returned as a solid residue together with variable amounts of water rich in water-soluble compounds, which currently are not addressed to any further application. The scope of this work was to evaluate the phytochemical composition of wastewaters coming from hydrodistillation (DWWs) of five aromatic plants belonging to the Lamiaceae family, and to assess their in vitro antioxidant and anti-inflammatory activities. The phenolic profiles of the DWWs were determined by HPLC-DAD and HPLC-ESI/MS. Free radical scavenging ability, oxygen radical antioxidant capacity and su…