Search results for "Disc"
showing 10 items of 19256 documents
Fragment‐ and Negative Image‐Based Screening of Phosphodiesterase 10A Inhibitors
2019
A novel virtual screening methodology called fragment‐ and negative image‐based (F‐NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A‐specific small‐molecule inhibitors are actively sought after for their antipsychotic and neuroprotective effects. The F‐NiB combines features from both fragment‐based drug discovery and negative image‐based (NIB) screening methodologies to facilitate rational drug discovery. The selected structural parts of protein‐bound ligand(s) are seamlessly combined with the negative image of the target's ligand‐binding cavity. This cavity‐ and fragment‐based hybrid model, namely its shape and electr…
Skolu un AS “Latvijas valsts meži” partnerība kompetenču pieejas īstenošanā
2020
Maģistra darba mērķis ir izpētīt skolu un AS “Latvijas valsts meži” partnerību starpdisciplinārā mācību temata “Pētījums mežā” īstenošanā un izstrādāt teorijā un praksē pamatotus ieteikumus šīs partnerības pilnveidei. Pētījumā iekļautas 2 partnerorganizācijas: AS “Latvijas valsts meži” un LU Starpnozaru izglītības inovāciju centrs, 6 temata izstrādes eksperti no minētajām partnerorganizācijām un 3 pilotskolām, kā arī 120 temata aprobācijā iesaistītie pedagogi no 68 vispārizglītojošajām skolām. Darbības pētījums balstās uz ekspertu fokusgrupas diskusiju, pedagogu snieguma novērojumu tālākizglītības kursos un aptauju pēc temata aprobācijas skolās, kā arī iegūto datu kontentanalīzi. Pētījuma r…
Sports teams as complex adaptive systems: manipulating player numbers shapes behaviours during football small-sided games
2016
Small-sided and conditioned games (SSCGs) in sport have been modelled as complex adaptive systems. Research has shown that the relative space per player (RSP) formulated in SSCGs can impact on emergent tactical behaviours. In this study we adopted a systems orientation to analyse how different RSP values, obtained through manipulations of player numbers, influenced four measures of interpersonal coordination observed during performance in SSCGs. For this purpose we calculated positional data (GPS 15 Hz) from ten U-15 football players performing in three SSCGs varying in player numbers (3v3, 4v4 and 5v5). Key measures of SSCG system behaviours included values of (1) players’ dispersion, (2) …
Antennal lobe representations are optimized when olfactory stimuli are periodically structured to simulate natural wing beat effects
2014
Animals use behaviors to actively sample the environment across a broad spectrum of sensory domains. These behaviors discretize the sensory experience into unique spatiotemporal moments, minimize sensory adaptation, and enhance perception. In olfaction, behaviors such as sniffing, antennal flicking, and wing beating all act to periodically expose olfactory epithelium. In mammals, it is thought that sniffing enhances neural representations; however, the effects of insect wing beating on representations remain unknown. To determine how well the antennal lobe produces odor-dependent representations when wing beating effects are simulated, we used extracellular methods to record neural units an…
Des théories pour repenser le contrôle de gestion : des dispositifs discursifs et instrumentaux ancrés dans un contexte social et institutionnel
2014
Los "femminielli" napolitanos: algunas reflexiones antropológicas
2021
The essay explores the anthropological meanings of Neapolitan "femminielli" and their gender implications
Les responsables de résidences très sociales : des professionnels tiraillés entre différents cadres d’appréhension de la réalité
2022
Cet article porte sur les responsables de résidences très sociales, entendons des responsables de structures locatives destinées à des individus et familles très modestes qui ne sont pas intégrés dans le logement social « traditionnel ». Le propos souligne les tensions relatives au métier en dégageant plus précisément divers formats et cadres d’appréhension de la réalité dans lesquels les agents de terrain ici concernés sont engagés d’une façon ou d’une autre. Ce faisant, il s’agit d’identifier diverses formes de contrôle (gestionnaire, discrétionnaire, sécuritaire...) qui ponctuent les journées de professionnels à la fois proches et éloignés aussi bien de « leurs » résidents que de leur in…
Interdiscursive Hybridity of European Social Dialogue
2011
The European social dialogue, which is the name given to the bipartite/tripartite work of the representative social partner organizations, has evolved significantly since it was first introduced in 1985 and constitutes one of the pillars of the European Union (artt.137-139 of the Treaty establishing the European Community). The European dialogue, which is based on the principles of responsibility, solidarity and participation, is now structured within the governance of the Union and allows the social partners to make an important contribution to the definition of European social standards (COM(2002)341 final; COM(2004)557 final). However, the system of social partnership and independent soc…
Greeks and Latins: a Disciplining Case in Monreale Archdiocese
2022
El objetivo de este artículo consiste en analizar la manera en que fueron articuladas las políticas de disciplinamiento en un contexto tan peculiar come el de la archidiócesis de Monreale, caracterizado por la coexistencia de dos comunidades de ritos diferentes, precisamente griego y latino. El estudio consta de dos partes principales: en la primera se reconstruye la llegada de los griegos-albaneses a Sicilia y la fundación de los asentamientos específicos para dichas poblaciones en el territorio de Monreale; en la segunda, mediante el análisis de las visitas pastorales llevadas a cabo en Piana dei Greci a caballo entre los siglos XVI y XVII, se analizan los diferentes mecanismos de discipl…
Double Marginalized Lives as Woman and as Refugee: Syrian Female Refugees in Ankara
2020
Este tesis establece cómo las refugiadas sirias son social, económica, cultural, étnica y sexualmente marginadas y lo que piensan acerca de los eventos en curso, su estado y los pasos que el gobierno y las ONGs han tomado hasta ahora para dar soluciones a la invisibilización de las mujeres en la esfera pública. Para ello, he llevado a cabo esta investigación en los suburbios de Ankara con un grupo de refugiadas sirias que están socialmente excluidas como “mujer'” y como “refugiada” y con un grupo de mujeres locales. La atención se centrará en la relación entre los discursos producidos en la sociedad de acogida y la exclusión social de las refugiadas sirias. Cabe señalar que la fuente de los…