Search results for "Disorder"
showing 10 items of 6405 documents
Profiles of mental well- and ill-being among elite athletes: Associations with sport-related demands and resources
2022
The aim of the present study was to identify profiles of elite athlete mental well- and ill-being and study how the profiles (i.e., subgroups of athletes) differed in sport-related demands and resources. A total of 259 Finnish elite athletes (n = 170 active and n = 89 retired) completed quantitative self-report inventories. Through cluster analysis, four profiles of mental well- and ill-being were identified. Profile 1 was overrepresented by retired, older, and male athletes, and characterized by good mental well-being. Profile 2 consisted mainly of active athletes who reported mild risk for alcohol abuse. Profile 3 consisted mainly of women who displayed possible presence of an eating diso…
Running a hybrid: mingling in-service and pre-service teachers in peer-mentoring groups
2020
his study examines a hybrid form of the Finnish Peer-Group Mentoring (PGM) merging student teachers and in-service teachers of different career stages in group meetings facilitated by an educated mentor. Experiences of the in-service participants were studied by interviewing them, and the data were analysed through thematic analysis. Four main themes were identified: 1) Enjoying group activities, 2) Personal professional development, 3) Attaching to the professional community and 4) Developing the teacher profession. The study shows that the hybrid model of peer-group mentoring enables opportunities for teacher learning that benefit both schools and teacher education institutions. peerRevie…
Thermal necrosis-aided dental implant removal:A rabbit model pilot study
2023
The significant advances in the materials and biological aspects of dental implants haven?t completely eradicated the implant failures. The removal of osseointegrated but otherwise failed implants present several challenges including adjacent tissues damage and necessity of bone augmentation for reimplantation. Controlled thermal necrosis has emerged as an alternative technique to aid removal of osseointegrated dental implants with minimal to no defect to healthy bone or surrounding tissues. This study aimed to evaluate the thermal necrosis-aided implant removal method in a rabbit osseointegration model. A total of 8 male New Zealand rabbits were used in the study. Two dental implants were …
Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
2012
Expansion of CAG repeats is a common feature of various neurodegenerative disorders, including Huntington's disease. Here we show that expanded CAG repeats bind to a translation regulatory protein complex containing MID1, protein phosphatase 2A and 40S ribosomal S6 kinase. Binding of the MID1-protein phosphatase 2A protein complex increases with CAG repeat size and stimulates translation of the CAG repeat expansion containing messenger RNA in a MID1-, protein phosphatase 2A- and mammalian target of rapamycin-dependent manner. Our data indicate that pathological CAG repeat expansions upregulate protein translation leading to an overproduction of aberrant protein and suggest that the MID1-com…
Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases
2021
Aging is a physiological process defined by decreased cellular and tissue functions. Reduced capacity of protein degradation is one of the important hallmarks of aging that may lead to misfolded protein accumulation and progressive loss of function in organ systems. Recognition of unfolded/misfolded protein aggregates via endoplasmic reticulum (ER) stress sensors activates an adaptive mechanism, the unfolded protein response (UPR). The initial step of UPR is defined by chaperone enhancement, ribosomal translation suppression, and misfolded protein degradation, while prolonged ER stress triggers apoptosis. MicroRNAs (miRNAs) are non-coding RNAs affecting various signaling pathways through de…
Profiling a spectrum of mental job demands and their linkages to employee outcomes
2020
Substance abuse, conduct disorder (CD) and attention deficit/hyperactivity disorder (ADHD) are all known risk factors for developing aggressive behaviors, criminality, other psychiatric comorbidity and substance use disorders (SUD). Since early age of onset is important for aggravating the impact of several of these risk factors, the aim of the present study was to investigate whether young adult violent offenders with different patterns of early onset externalizing problems (here: substance use < age 15, ADHD, CD) had resulted in different criminality profiles, substance use problem profiles and psychiatric comorbidity in young adult age. A mixed-method approach was used, combining a varia…
Cortical hypoactivity or reduced efficiency of cortical inhibition in migraine?. vol. 27, pp. 187-188.
2007
Walking Stroop carpet: an innovative dual-task concept for detecting cognitive impairment
2013
A Perrochon,1,2,5 G Kemoun,1,2 E Watelain,3,4 A Berthoz51ISIS, Research Institute on Handicap and Aging, Paris; 2Universit&eacute; de Poitiers, Laboratoire Mobilit&eacute;, Vieillissement et Exercice (MOVE), EA 6314, 3Universit&eacute; de Valenciennes, LAMIH, UMR CNRS 8201, 4Universit&eacute; Sud Toulon Var, HandiBio, EA 4322, La Garde, 5LPPA, UMR CNRS 7152, Coll&egrave;ge de France, Paris, FranceBackground: Several studies have reported the potential value of the dual-task concept during locomotion in clinical evaluation because cognitive decline is strongly associated with gait abnormalities. However, current dual-task tests appear to be insufficient for early diagnosi…
Brain Opioid Activity and Oxidative Injury: Different Molecular Scenarios Connecting Celiac Disease and Autistic Spectrum Disorder
2020
Celiac Disease (CD) is an immune-mediated disease triggered by the ingestion of wheat gliadin and related prolamins from other cereals, such as barley and rye. Immunity against these cereal-derived proteins is mediated by pro-inflammatory cytokines produced by both innate and adaptive system response in individuals unable to adequately digest them. Peptides generated in this condition are absorbed across the gut barrier, which in these patients is characterized by the deregulation of its permeability. Here, we discuss a possible correlation between CD and Autistic Spectrum Disorder (ASD) pathogenesis. ASD can be induced by an excessive and inappropriate brain opioid activity during the neon…
Smoking cessation, anxiety, mood and quality of life: reassuring evidences.
2014
A close and complex relationship between smoking and mental health problems was found. Different hypotheses have been proposed to explain these associations: 1) smoking and poor mental health may share common causes (genetic factors or environmental mechanisms); 2) for people with poor mental health smoking is a coping strategy to regulate psychiatric symptoms; 3) smokings worsen mental health. Moreover, smokers with psychiatric disorders may have more difficulty quitting and patients with mental diseases who received mental health treatment within the previous year were more likely to stop smoking than those not receiving treatment. Taylor et al. hypothesized that quitting smoking might im…