Search results for "Disorders"
showing 10 items of 4560 documents
Additional file 2: of Novel subpopulations in date palm (Phoenix dactylifera) identified by population-wide organellar genome sequencing
2019
Mitochondrial and Chloroplast Haplotype SNP Positions. Table containing genotypes for all intra-date palm SNP positions in the Mitochondrial and Chloroplast haplotypes identified in this study. (XLSX 18 kb)
Running a hybrid: mingling in-service and pre-service teachers in peer-mentoring groups
2020
his study examines a hybrid form of the Finnish Peer-Group Mentoring (PGM) merging student teachers and in-service teachers of different career stages in group meetings facilitated by an educated mentor. Experiences of the in-service participants were studied by interviewing them, and the data were analysed through thematic analysis. Four main themes were identified: 1) Enjoying group activities, 2) Personal professional development, 3) Attaching to the professional community and 4) Developing the teacher profession. The study shows that the hybrid model of peer-group mentoring enables opportunities for teacher learning that benefit both schools and teacher education institutions. peerRevie…
Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
2012
Expansion of CAG repeats is a common feature of various neurodegenerative disorders, including Huntington's disease. Here we show that expanded CAG repeats bind to a translation regulatory protein complex containing MID1, protein phosphatase 2A and 40S ribosomal S6 kinase. Binding of the MID1-protein phosphatase 2A protein complex increases with CAG repeat size and stimulates translation of the CAG repeat expansion containing messenger RNA in a MID1-, protein phosphatase 2A- and mammalian target of rapamycin-dependent manner. Our data indicate that pathological CAG repeat expansions upregulate protein translation leading to an overproduction of aberrant protein and suggest that the MID1-com…
Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases
2021
Aging is a physiological process defined by decreased cellular and tissue functions. Reduced capacity of protein degradation is one of the important hallmarks of aging that may lead to misfolded protein accumulation and progressive loss of function in organ systems. Recognition of unfolded/misfolded protein aggregates via endoplasmic reticulum (ER) stress sensors activates an adaptive mechanism, the unfolded protein response (UPR). The initial step of UPR is defined by chaperone enhancement, ribosomal translation suppression, and misfolded protein degradation, while prolonged ER stress triggers apoptosis. MicroRNAs (miRNAs) are non-coding RNAs affecting various signaling pathways through de…
Profiling a spectrum of mental job demands and their linkages to employee outcomes
2020
Substance abuse, conduct disorder (CD) and attention deficit/hyperactivity disorder (ADHD) are all known risk factors for developing aggressive behaviors, criminality, other psychiatric comorbidity and substance use disorders (SUD). Since early age of onset is important for aggravating the impact of several of these risk factors, the aim of the present study was to investigate whether young adult violent offenders with different patterns of early onset externalizing problems (here: substance use < age 15, ADHD, CD) had resulted in different criminality profiles, substance use problem profiles and psychiatric comorbidity in young adult age. A mixed-method approach was used, combining a varia…
Cortical hypoactivity or reduced efficiency of cortical inhibition in migraine?. vol. 27, pp. 187-188.
2007
Walking Stroop carpet: an innovative dual-task concept for detecting cognitive impairment
2013
A Perrochon,1,2,5 G Kemoun,1,2 E Watelain,3,4 A Berthoz51ISIS, Research Institute on Handicap and Aging, Paris; 2Universit&eacute; de Poitiers, Laboratoire Mobilit&eacute;, Vieillissement et Exercice (MOVE), EA 6314, 3Universit&eacute; de Valenciennes, LAMIH, UMR CNRS 8201, 4Universit&eacute; Sud Toulon Var, HandiBio, EA 4322, La Garde, 5LPPA, UMR CNRS 7152, Coll&egrave;ge de France, Paris, FranceBackground: Several studies have reported the potential value of the dual-task concept during locomotion in clinical evaluation because cognitive decline is strongly associated with gait abnormalities. However, current dual-task tests appear to be insufficient for early diagnosi…
Influence of Musical Context on the Perception of Emotional Expression of Music
2013
Factors determining and influencing the perception of emotional expression of music include those related to music itself, to the listener, and to the context. Among the latter there is also music, as we rarely listen to a single piece. A simple experimental study has been carried out into the effect of music listened to immediately beforehand on the perception of the emotional expression of a musical piece. The following variables were involved: type of emotional expression of music conceived in terms of a most basic sad-joyful dimension, initial and final mood of the listeners, their professional musical education vs. lack thereof, age, and gender. The subjects were students of three age …
Influence of voluntary work intervention on the mood status of older volunteers
2012
The aim of this study was to investigate the positive and depressive mood changes in older volunteers after a three-month voluntary work intervention through a one-group experimental research design. The participants were drawn from the Volunteering, access to Outdoor activities and Wellbeing in older people (VOW) project. The participants were recently retired group, aged 50 and above (N=47, 42 female). Prior training sessions were arranged for the participants before the intervention period. Pre and post assessment of depressive mood was measured through applying the original form of Center for Epidemiologic Studies Depression Scale (CES-D) and positive mood was measure through the positi…