Search results for "Disruption"
showing 10 items of 52 documents
A CASCADE of effects of bisphenol A
2009
International audience
Two Enhancers Control Transcription of Drosophila muscleblind in the Embryonic Somatic Musculature and in the Central Nervous System
2014
The phylogenetically conserved family of Muscleblind proteins are RNA-binding factors involved in a variety of gene expression processes including alternative splicing regulation, RNA stability and subcellular localization, and miRNA biogenesis, which typically contribute to cell-type specific differentiation. In humans, sequestration of Muscleblind-like proteins MBNL1 and MBNL2 has been implicated in degenerative disorders, particularly expansion diseases such as myotonic dystrophy type 1 and 2. Drosophila muscleblind was previously shown to be expressed in embryonic somatic and visceral muscle subtypes, and in the central nervous system, and to depend on Mef2 for transcriptional activatio…
Entrapment of A Beta 1-40 peptide in unstructured aggregates
2012
Recognizing the complexity of the fibrillogenesis process provides a solid ground for the development of therapeutic strategies aimed at preventing or inhibiting protein-protein aggregation. Under this perspective, it is meaningful to identify the possible aggregation pathways and their relative products. We found that Aβ-peptide dissolved in a pH 7.4 solution at small peptide concentration and low ionic strength forms globular aggregates without typical amyloid β-conformation. ThT binding kinetics was used to monitor aggregate formation. Circular dichroism spectroscopy, AFM imaging, static and dynamic light scattering were used for structural and morphological characterization of the aggre…
Transcription of genes in the biosynthetic pathway for fumonisin mycotoxins is epigenetically and differentially regulated in the fungal maize pathog…
2012
ABSTRACT When the fungal pathogen Gibberella moniliformis (anamorph, Fusarium verticillioides ) colonizes maize and maize-based products, it produces class B fumonisin (FB) mycotoxins, which are a significant threat to human and animal health. FB biosynthetic enzymes and accessory proteins are encoded by a set of clustered and cotranscribed genes collectively named FUM, whose molecular regulation is beginning to be unraveled by researchers. FB accumulation correlates with the amount of transcripts from the key FUM genes, FUM1 , FUM21 , and FUM8 . In fungi in general, gene expression is often partially controlled at the chromatin level in secondary metabolism; when this is the case, the deac…
Chitin synthetase activity in Candida albicans: subcellular distribution in yeast cells and protoplasts
1991
Chitin synthetase activity was detected in a partly zymogenic form in cell-free homogenates obtained from C. albicans yeast cells and protoplasts of the same type of cells. By isopycnic centrifugation on sucrose gradients of the cell-free homogenates two fractions with chitin synthetase activity were obtained: one was associated with the plasma membrane (labelled with [ 3 H]concanavalin A (con A) and buoyant density 1·195 g ml −1 ) in a partly active state, and the second was in the cytoplasm, where the enzyme was in a particulate fully zymogenic form, lacking affinity to con A. The buoyant density of the enzyme found in this location depended on the method of cell breakage. Lysis of partly…
REMITTANCES IMPACTS ON SCHOOLING IN JORDAN: ANALYSES WITH RESPECT TO MIGRANT DESTINATION
2019
The two channels that explain how migration of a household member affects human capital formation of those left-behind are income and family disruption effects. In this study, remittances and migration impacts on human capital formation in Jordan is researched with respect to preferred migrant destinations and to the originating governorates of migrants. Jordan’s Labour Market Panel Survey-2010 is used to carry out the analyses. Remittances are found to have a positive impact on “schooling”, and findings do not change significantly across households with respect to the host country. There is no solid evidence of family disruption, except in households where both parents are absent; however,…
Frisian as an Endangered Language: An Overview
2019
The main goal of the paper is to answer the questions whether Frisian can be referred to as an endangered language and if it managed to survive the constant influence of the surrounding larger cultures and languages. The first point to be analyzed is the geographic distribution of Frisian. The second issue to be considered is the historical and present cultural and social status of the Frisian language. The third matter to be analysed is the lexical variety of Frisian language and its complexity, which made its survival possible. The article takes the diachronic perspective and expounds upon all the mentioned factors and their role in the preservation of Frisian until today. The paper prese…
Long-Term Behavioral Programming Induced by Peripuberty Stress in Rats Is Accompanied by GABAergic-Related Alterations in the Amygdala
2014
Stress during childhood and adolescence is a risk factor for psychopathology. Alterations in γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain, have been found following stress exposure and fear experiences and are often implicated in anxiety and mood disorders. Abnormal amygdala functioning has also been detected following stress exposure and is also implicated in anxiety and social disorders. However, the amygdala is not a unitary structure; it includes several nuclei with different functions and little is known on the potential differences the impact of early life stress may have on this system within different amygdaloid nuclei. We aimed here to evaluate pote…
Implications for dark matter direct detection in the presence of LIGO-motivated primordial black holes
2019
We discuss formation of dark matter (DM) mini-halos around primordial black holes (PBHs) and its implication on DM direct detection experiments, including axion searches. Motivated by LIGO observations, we consider $f_{\textrm{DM}} \simeq 0.01$ as the fraction of DM in PBHs with masses $10 M_{\odot} - 70 M_{\odot}$. In this case, we expect the presence of dressed PBHs after Milky Way halo formation with mini-halo masses peaked around $M_{\textrm{halo}} \sim (50-55) M_{\textrm{PBH}}$. We analyze the effect of tidal forces acting on dressed PBHs within the Milky Way galaxy. In the solar neighborhood, the mini-halos are resistant against tidal disruption from the mean-field potential of the ga…
The THESEUS space mission concept: science case, design and expected performances
2018
THESEUS is a space mission concept aimed at exploiting Gamma-Ray Bursts for investigating the early Universe and at providing a substantial advancement of multi-messenger and time-domain astrophysics. These goals will be achieved through a unique combination of instruments allowing GRB and X-ray transient detection over a broad field of view (more than 1sr) with 0.5¿1 arcmin localization, an energy band extending from several MeV down to 0.3¿keV and high sensitivity to transient sources in the soft X-ray domain, as well as on-board prompt (few minutes) follow-up with a 0.7¿m class IR telescope with both imaging and spectroscopic capabilities. THESEUS will be perfectly suited for addressing …