Search results for "Dog"

Incipient genome erosion and metabolic streamlining for antibiotic production in a defensive symbiont

2021

Significance Genome reduction is commonly observed in bacteria of several phyla engaging in obligate nutritional symbioses with insects. In Actinobacteria, however, little is known about the process of genome evolution, despite their importance as prolific producers of antibiotics and their increasingly recognized role as defensive partners of insects and other organisms. Here, we show that “Streptomyces philanthi,” a defensive symbiont of digger wasps, has a G+C-enriched genome in the early stages of erosion, with inactivating mutations in a large proportion of genes, causing dependency on its hosts for certain nutrients, which was validated in axenic symbiont cultures. Additionally, overe…

Anaplastic Thyroid Carcinoma: A ceRNA Analysis Pointed to a Crosstalk between SOX2, TP53, and microRNA Biogenesis.

2014

It has been suggested that cancer stem cells (CSC) may play a central role in oncogenesis, especially in undifferentiated tumours. Anaplastic thyroid carcinoma (ATC) has characteristics suggestive of a tumour enriched in CSC. Previous studies suggested that the stem cell factorSOX2has a preeminent hierarchical role in determining the characteristics of stem cells in SW1736 ATC cell line. In detail, silencing SOX2 in SW1736 is able to suppress the expression of the stem markers analysed, strongly sensitizing the line to treatment with chemotherapeutic agents. Therefore, in order to further investigate the role of SOX2 in ATC, a competing endogenous RNA (ceRNA) analysis was conducted in order…

On the origin of mongrels: evolutionary history of free-breeding dogs in Eurasia

2015

Although a large part of the global domestic dog population is free-ranging and free-breeding, knowledge of genetic diversity in these free-breeding dogs (FBDs) and their ancestry relations to pure-breed dogs is limited, and the indigenous status of FBDs in Asia is still uncertain. We analyse genome-wide SNP variability of FBDs across Eurasia, and show that they display weak genetic structure and are genetically distinct from pure-breed dogs rather than constituting an admixture of breeds. Our results suggest that modern European breeds originated locally from European FBDs. East Asian and Arctic breeds show closest affinity to East Asian FBDs, and they both represent the earliest branching…

ROOT-KNOT NEMATODES FROM ASPARAGUS AND ASSOCIATED BIOLOGICAL ANTAGONISTS IN PERU

2012

A research study on the parasitic nematodes of asparagus and several associated antagonists was carried out in Northern Peru. Nematodes were identified by means of light microscopy and sequencing of the ITS1-2 regions. Nematophagous fungi were isolated from nematode-infested roots or soil, cultured in vitro and maintained in a culture collection for further characterization. The species recovered were mainly root-knot nematodes including Meloidogyne incognita and M. ethiopica. Nematophagous fungi identified through standard morphological methods as well as by ITS sequencing included Drechslerella brochopaga, Lecanicillium psalliotae and Monacrosporium sp. Meloidogyne ethiopica and the antag…

"Introduzione" in Merenda A, Mainardi, L., Tura, G (a cura di) La cinoterapia e le relazioni di cura

2019

On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro

1986

1. Guinea-pig isolated atria were incubated and loaded with 3H-(−)-noradrenaline. The intrinsic nerves were stimulated with trains of 5 or 35 field pulses (4 Hz), and the evoked efflux of 3H-noradrenaline and of total tritium was determined in the presence of atropine, corticosterone, desipramine, and phentolamine by liquid scintillation spectrometry. 2. Ethylketocyclazocine (1.4 nmol/l, IC50), MR 2033 (9.1 nmol/l), dynorphin A (1–13) (25 nmol/l, peptidase inhibitors present), etorphine (71 nmol/l), and [d-Ala2, d-Leu5]-enkephalin (>10 μmol/l, peptidase inhibitors present) inhibited the stimulation-evoked efflux of 3H-noradrenaline in a concentration-dependent manner, but not morphine up to…

Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

2019

Este es el artículo que se ha publicado de forma definitiva en: https://molecularautism.biomedcentral.com/articles/10.1186/s13229-019-0262-8 En este artículo también participa Joan Climent, Vera Pancaldi, Lourdes Fañanás, Celso Arango, Mara Parellada, Anaïs Baudot, Daniel Vogt, John L. Rubenstein, Alfonso Valencia y Rafael Tabarés-Seisdedos. Background: Epidemiological and clinical evidence points to cancer as a comorbidity in people with autism spectrum disorders (ASD). A significant overlap of genes and biological processes between both diseases has also been reported. Methods: Here, for the first time, we compared the gene expression profiles of ASD frontal cortex tissues and 22 cancer t…

Autocorrelation Metrics to Estimate Soil Moisture Persistence From Satellite Time Series: Application to Semiarid Regions

2021

Satellite-derived soil moisture (SM) products have become an important information source for the study of land surface processes in hydrology and land monitoring. Characterizing and estimating soil memory and persistence from satellite observations is of paramount relevance, and has deep implications in ecology, water management, and climate modeling. In this work, we address the problem of SM persistence estimation from microwave sensors using several autocorrelation metrics that, unlike traditional approaches, build on accurate estimates of the autocorrelation function from nonuniformly sampled time series. We show how the choice of the autocorrelation estimator can have a dramatic impac…

PRODUCTION OF CANINE MESENCHYMAL STEM CELLS FROM ADIPOSE TISSUE AND APPLICATION IN DOGS WITH CHRONIC OSTEOARTHRITIS OF THE HUMERORADIAL JOINTS

2012

Autoritarisme de dretes: antecedents i perspectives de futur

2012

Aquest article presenta els principals antecedents per a l'estudi psicològic de l'autoritarisme de dretes. Per a tal fi es parteix dels treballs del Grup de Berkeley (1950) sobre la personalitat autoritària, posteriorment s'introdueix el concepte de dogmatisme proposat per Rokeach (1960) i després es comenten les aportacions d'Altemeyer (1981, 2004) sobre l'autoritarisme de dretes. Després es discuteix la possibilitat de l'estudi de l'autoritarisme en el continu ideològic d'esquerres i finalment s'exposen alguns dels avanços de l'última dècada sobre la dimensionalitat del constructe (Funke 2005, Mavor, Louis & Laythe 2011, Smith & Winter 2002), que permetrà avançar en l'esclariment del conf…