Search results for "Dol"
showing 10 items of 13430 documents
Projecte d'investigació-acció: Violència escolar i integració social
2006
En aquest treball es presenta el Projecte d'Investigació-Acció realitzat pel grup Lisis de la Universitat de València. Des del model ecològic, l'interès està a analitzar i prevenir la conducta violenta entre iguals a l'escola. Per a això s'ha aplicat en una mostra de 1319 adolescents d'edats compreses entre els 11 i els 16 anys una bateria d'instruments. En aquest article s'exposa, a tall d'exemple, un dels models d'equacions estructurals calculats en aquesta investigació. En concret s'analitza l'efecte directe i l'indirecte del clima familiar en la conducta violenta entre iguals i en el context escolar.
Intégration d’une prospection géophysique dans la démarche de cartographie des sols : Exemple de l’unité expérimentale d’Epoisses
2016
Intégration d’une prospection géophysique dans la démarche de cartographie des sols : Exemple de l’unité expérimentale d’Epoisses. 13. Journées d'Etudes des Sols
Frecuencia del consumo de drogas legales: Diferencias de edad en la adolescencia
2007
El consumo de drogas es especialmente relevante por sus efectos negativos sobre la salud psicofísica y el funcionamiento social de los jóvenes. El objetivo de este estudio fue analizar las diferencias de edad respecto a las frecuencias de consumo de alcohol y tabaco en una muestra de 354 escolares (50.85% varones) de 12 a 18 años (M = 14.66; DT = 1.08) que cumplimentaron el Questionnarie about Consume of Alcohol and Tobacco (TNT). Los resultados muestran que el 82.4% de los adolescentes ha consumido bebidas alcohólicas en alguna ocasión y el 25.6% es consumidor actualmente. Respecto al consumo de tabaco, el 40.4% de estudiantes afirma haber fumado en alguna ocasión, siendo consumidores actu…
Evaluation of the impact of different odour notes on typicality of caramel aroma by recombination studies
2013
Poster (1 page); International audience; Aroma is one of the main factors that contribute to the consumer acceptability of a food product. Gas Chromatography/Olfactometry (GC/O) followed by accurate quantitation and recombination studies are usually carried out to evaluate key aroma compounds. The aim of this study is to develop a new approach taking into account odor qualities and to evaluate their impact on the typicality of caramel aroma. First, 58 aroma compounds, previously identified by GC/O analyses, were sorted into 8 odorant categories: animal, caramel, sour, vegetal, roasted, floral, fruity and nutty according to GC/O descriptors. For each category, a blend of compounds was prepar…
Neural Networks in ECG Classification
2011
In this chapter, we review the vast field of application of artificial neural networks in cardiac pathology discrimination based on electrocardiographic signals. We discuss advantages and drawbacks of neural and adaptive systems in cardiovascular medicine and catch a glimpse of forthcoming developments in machine learning models for the real clinical environment. Some problems are identified in the learning tasks of beat detection, feature selection/extraction, and classification, and some proposals and suggestions are given to alleviate the problems of interpretability, overfitting, and adaptation. These have become important problems in recent years and will surely constitute the basis of…
Bioactivation of the Fungal Phytotoxin 2,5-Anhydro-D-glucitol by Glycolytic Enzymesisan Essential Component of itsMechanism of Action
2002
An isolate of Fusarium solani, NRRL 18883, produces the natural phytotoxin 2,5-anhydro-ᴅ-glucitol (AhG). This fungal metabolite inhibited the growth of roots (I50 of 1.6 mᴍ), butit did nothave any in vitro inhibitory activity. The mechanism of action of AhG requires enzymatic phosphorylation by plant glycolytic kinases to yield AhG-1,6-bisphosphate (AhG-1,6- bisP), an inhibitor of Fru-1,6-bisP aldolase. AhG-1,6-bisP had an I50 value of 570 μᴍ on aldolase activity, and it competed with Fru-1,6-bisP for the catalytic site on the enzyme, with a Ki value of 103 μᴍ. The hydroxyl group on the anomeric carbon of Fru-1,6-bisP is required for the formation of an essential covalent bond to ζ amino fu…
Catalytic enantioselective Friedel–Crafts alkylation at the 2-position of indole with simple enones
2007
Abstract A procedure for the enantioselective alkylation of indole at the 2-position with simple non-chelating enones is described for the first time. Reaction between 4,7-dihydroindole and enones in the presence of zirconium(IV)–BINOL complexes, followed by a p -benzoquinone oxidation gives indoles alkylated at the 2-position with good yields and moderate enantioselectivities.
sj-pdf-1-smr-10.1177_00491241221092725 - Supplemental material for Improving Estimates Accuracy of Voter Transitions. Two New Algorithms for Ecologic…
2022
Supplemental material, sj-pdf-1-smr-10.1177_00491241221092725 for Improving Estimates Accuracy of Voter Transitions. Two New Algorithms for Ecological Inference Based on Linear Programming by Jose M. Pavía and Rafael Romero in Sociological Methods & Research
Synthesis, Anti-Inflammatory Activity, and in Vitro Antitumor Effect of a Novel Class of Cyclooxygenase Inhibitors: 4-(Aryloyl)phenyl Methyl Sulfones
2010
Following our previous research on anti-inflammatory drugs (NSAIDs), we report on the design and synthesis of 4-(aryloyl)phenyl methyl sulfones. These substances were characterized for their capacity to inhibit cyclooxygenase (COX-1 and COX-2) isoenzymes. Molecular modeling studies showed that the methylsulfone group of these compounds was inserted deep in the pocket of the human COX-2 binding site, in an orientation that precludes hydrogen bonding with Arg120, Ser353, and Tyr355 through their oxygen atoms. The N-arylindole 33 was the most potent inhibitor of COX-2 and also the most selective (COX-1/COX-2 IC(50) ratio was 262). The indole derivative 33 was further tested in vivo for its ant…
Phenotypic analysis of individuals with Costello syndrome due to HRAS p.G13C.
2011
Costello syndrome is characterized by severe failure-to-thrive, short stature, cardiac abnormalities (heart defects, tachyarrhythmia, and hypertrophic cardiomyopathy (HCM)), distinctive facial features, a predisposition to papillomata and malignant tumors, postnatal cerebellar overgrowth resulting in Chiari 1 malformation, and cognitive disabilities. De novo germline mutations in the proto-oncogene HRAS cause Costello syndrome. Most mutations affect the glycine residues in position 12 or 13, and more than 80% of patients share p.G12S. To test the hypothesis that subtle genotype-phenotype differences exist, we report the first cohort comparison between 12 Costello syndrome individuals with p…