Search results for "Dominance"
showing 10 items of 360 documents
Immune activation promotes evolutionary conservation of T-cell epitopes in HIV-1.
2013
The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (TH cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient l…
Epidural hematoma after cochlear implantation in a 2.5-year-old boy.
2005
OBJECTIVE Report a case of an epidural hematoma after cochlear implantation in a 2.5-year-old boy, the diagnostic and therapeutical emergency management, as well as the postinterventional course and rehabilitation of the child. STUDY DESIGN Retrospective case review. PATIENT Two and a half-year-old boy, suffering from early onset, profound sensorineural hearing loss had been diagnosed at an age of 1.5 years, which had been more severe on the right side initially, but had progressed to bilateral deafness. INTERVENTION AND COMPLICATION: Cochlear implantation on the left side, followed up by an extensive epidural hematoma, causing intracranial compression with a midline shift of 15 mm to the r…
Spatial Structures of the Philippines: Urbanization and Regional Inequalities
2017
This chapter examines the fundamental spatial structures of the Philippines. It defines the role and organization of the different levels of the administrative hierarchy (provinces, regions, cities and municipalities) down to the barangay and sitio/purok levels. This leads to the definition of the “urban” in the Philippines and the rise of urbanization in recent decades, from the original urban settlements of the Spanish era, with their patterns following the same rules as in Latin America (fort, church and plaza), to today’s cities. Forms of housing have evolved over time, from the archetypal bamboo/nipa hut (bahay kubo) and the urban stone and wood house of the elites (bahay na bato), now…
Power and Legitimizing Ideologies in Hierarchy-Enhancing vs. Hierarchy-Attenuating Environments
2012
According to social dominance theory, intergroup dynamics are strongly influenced by the social positions which individuals hold in society. Several studies suggest that holding a position of power can, sometimes automatically, generate negative attitudes and hostile behaviors toward subordinate social groups. However, at present, the studies carried out on these effects of power have not taken into account the influence of the normative context. Based on the distinction made by Sidanius and Pratto between “hierarchy-enhancing” (HE) vs. “hierarchy-attenuating” (HA) environments, this study examines if the effects of power on legitimizing cognitions vary as a function of the normative enviro…
Scalar, axial-vector, and tensor resonances from the rho D-*, omega D-* interaction in the hidden gauge formalism
2009
13 pages, 15 figures.-- PACS nrs.: 13.75.Lb, 12.40.Vv, 12.40.Yx, 14.40.Cs.-- ArXiv pre-print available at: http://arxiv.org/abs/0903.3823
Revealing financial accounting in Finland under five historical themes
2009
This article deals with the historical development of financial accounting in Finland from 1862 to 2005. The period starts with the publication of the first Finnish accounting textbook by August Lilius in 1862. The year 2005 marks another milestone: this was when all listed companies were obligated to prepare consolidated accounts according to IAS/ IFRS standards. The study applies a discourse analysis approach and presents Finnish financial accounting history under five discourses or themes, namely: entrepreneurship, academic, governance control, professional and financial market themes. Some of these have assumed more dominance over time while others have lost much of their former signifi…
Experimental Preemptive Immunotherapy of Murine Cytomegalovirus Disease with CD8 T-Cell Lines Specific for ppM83 and pM84, the Two Homologs of Human …
2001
ABSTRACTCD8 T cells are the principal antiviral effectors controlling cytomegalovirus (CMV) infection. For human CMV, the virion tegument protein ppUL83 (pp65) has been identified as a source of immunodominant peptides and is regarded as a candidate for cytoimmunotherapy and vaccination. Two sequence homologs of ppUL83 are known for murine CMV, namely the virion protein ppM83 (pp105) expressed late in the viral replication cycle and the nonstructural protein pM84 (p65) expressed in the early phase. Here we show that ppM83, unlike ppUL83, is not delivered into the antigen presentation pathway after virus penetration before or in absence of viral gene expression, while other virion proteins o…
The immunogenicity of human and murine cytomegaloviruses.
2000
Cytomegaloviruses are strictly host-species-specific. During an aeon of co-evolution, virus and host have found an arrangement: the productive and cytopathogenic cycle of viral gene expression is held in check by the host's immune response. As a consequence, cytomegalovirus disease is restricted to the immunocompromised host. The virus has evolved strategies to avoid its elimination and eventually hides itself in a silent state, referred to as 'viral latency'. Redundant molecular mechanisms have been identified by which cytomegaloviruses interfere with antigen presentation pathways to 'evade' immune control. In the annual period covered by this review, the IE1 protein was revisited as an im…
Male dominance and immunocompetence in a field cricket
2004
Female preference for dominant males has been found in many species, and it is generally thought that winners of male-male competition are of superior quality. Success in contests probably depends on male condition and overall health. Thus, females could avoid infection and gain genetic benefits in terms of more viable offspring by mating with dominant males. In the present study, we tested whether dominant males of the Mediterranean field cricket, Gryllus bimaculatus, had higher immunocompetence than did their subordinates in experimental trials. We found that dominant males had better immune defense, as indicated by significantly higher encapsulation rate and lytic activity, than did subo…
Stalemating a clever opportunist: lessons from murine cytomegalovirus.
2003
Abstract Cytomegaloviruses and their specific hosts have come to an arrangement that avoids disease but allows the viruses to persist in the individual host and to spread in the host species. Recent work has uncovered some of the molecular details of this evolutionary “contract for mutual survival.” Cytomegaloviruses encode proteins, referred to as “immunoevasins,” which are specifically committed to subvert the immune defense of the host for evading virus elimination. In reply, the hosts have evolved countermeasures to overcome the viral immunoevasins and present antigenic peptides to an extent that is sufficient for confining virus replication to below a harmful level. Accordingly, cytome…