Search results for "Dominant"

T cells engineered to express a T-cell receptor specific for glypican-3 to recognize and kill hepatoma cells in vitro and in mice

2015

Background & Aims Cancer therapies are being developed based on our ability to direct T cells against tumor antigens. Glypican-3 (GPC3) is expressed by 75% of all hepatocellular carcinomas (HCC), but not in healthy liver tissue or other organs. We aimed to generate T cells with GPC3-specific receptors that recognize HCC and used them to eliminate GPC3-expressing xenograft tumors grown from human HCC cells in mice. Methods We used mass spectrometry to obtain a comprehensive peptidome from GPC3-expressing hepatoma cells after immune-affinity purification of human leukocyte antigen (HLA)-A2 and bioinformatics to identify immunodominant peptides. To circumvent GPC3 tolerance resulting from feta…

A continuous infusion of a minor histocompatibility antigen-immunodominant peptide induces a delay of male skin graft rejection.

2009

Abstract We previously reported that an inhibition of antigen-specific Interferon-γ release and cytotoxicity occurs after a continuous infusion of an HY immunodominant peptide although this treatment is not able to cause a significant delay of male skin grafts rejection. In vivo administration of high doses of an HY peptide, through mini-osmotic pumps, in naive female mice was used to study the effects on the male skin grafts rejection. A continuous infusion of 1 mg of an HY peptide induces a significant delay of male skin graft rejection. In vitro HY-specific Interferon-γ release was inhibited adding peptide-specific suppressor cells: the ability to inhibit Interferon-γ release was evident…

Gestācijas dominantes psiholoģiskās komponentes hipogestognostiskā varianta izplatība un saistība ar atioforiognoziju dzemdību palīdzības iestādes pa…

2015

Ievads. Gestācijas dominantes psiholoģiskā komponente ir psihisko pašregulācijas mehānismu kopums grūtniecības saglabāšanai. Hipogestognostiskais variants raksturīgs sievietēm, kuras apzināti vai biežāk neapzināti nepieņem savu grūtniecību. Sakarā ar to, ka gestācijas dominantes psiholoģiskās komponentes hipogestognostiskais variants ir cieši saistīts ar grūtniecības noliegšanu, kas apdraud gan mātes, gan bērna dzīvību, nepieciešams pēc iespējas agrīni novērtēt grūtnieces psiholoģisko stāvokli. Pētījuma mērķis. Veicot prospektīvo pētījumu novērtēt grūtnieču gestācijas dominantes psiholoģiskās komponentes hipogestognostiskā varianta biežumu, kā arī noskaidrot grūtniecības nelabvēlīga iznākum…

Rapid molecular dissection of viral and bacterial immunomes

2006

The development of preventive or therapeutic recombinant vaccines and the generation of serodiagnostic assays for infectious diseases depend essentially on the availability of molecularly defined antigens. A major bottleneck for the identification of suitable target antigens for many pathogens is the isolation of sufficient amounts of material for subsequent genomic or proteomic screening. Applying a highly efficient expression cloning strategy to the human pathogens vaccinia virus (VV) and Chlamydia pneumoniae (CP), we demonstrate that sub-nanogram amounts of isolated nucleic acids can be utilized to determine comprehensive sets of immunodominant antigens. Remarkably, the approach not only…

México, el aprendizaje de la democracia

2006

La clase dominante y la sustitución del franquismo

1977

Existe otra versión publicada en: Tamames, Ramón (Dir.) (1977). Anuario Economico y Social (pp. 19-58). Barcelona: Iberplan, Planeta.

Implosión democrática / 1

2008

La corrupción de la democracia

2009

Perceptions of Refugees Towards Finns and Immigrants

2021

Building off of the previous two chapters, this chapter looks at the refugee experience from the point of view of the refugee. While the overwhelming majority of integrated threat studies have been conducted from the point of view of the dominant culture, and a few from the point of view of an immigrant or minority’s perspective, none have explored threat from the point of view of a refugee. Therefore, for a more holistic picture of the Finnish migration situation, and the situation of refugees in Finland, we explored how refugees see threat, migration, their situation, Finns, and other immigrants in Finland. Thus, through the use of in-depth interviews, this chapter explores the perception…

Path dependence and landscape: initial conditions, contingency and sequences of events in latgale, latvia

2013

AbstractThe notion of path dependence has not yet been well explored as a tool for analysing landscape change. Within geography it is primarily economic geographers who have, up until now, shown a keen interest in this concept which stresses the role of social agency and institutions in understanding the development trajectories of regions. Further, the notion of path dependence usefully captures the idea of contingency in historical sequences. This article presents such a perspective on landscape change analysis, discussing two dominant types of sequences in path‐dependent systems. Self‐reinforcing sequences characterize the formation and long‐term reproduction of a given institutional pat…