Search results for "Domo"
showing 10 items of 508 documents
Acinetobacter baumannii un Pseudomonas aeruginosa antibakteriālās rezistences noteikšana, lietojot fenotipiskās un molekulāri bioloģiskās metodes
2020
Acinetobacter baumannii un Pseudomonas aeruginosa ir gan Latvijā, gan visā Eiropā bieži sastopami intrahospitāli patogēni, pret kuriem antibiotiku rezistence pieaug ik gadu. Visbiežāk tie skar imūnsupresētus cilvēkus, apdraudot veselību un dzīvību. Darba mērķis: Noteikt A.baumannii un P. aeruginosa jutību pret antibakteriālajiem līdzekļiem 2019. gadā un salīdzināt rezistences izmaiņas ar 2017. gadu, kā arī ar molekulāri bioloģisko metodi identificēt baktēriju sugas. Uzdevumi: 1.No elpceļu paraugiem ar BBL CrystalTM identifikācijas sistēmām identificēt izolātus. 2. Noteikt antimikrobiālo jutību, izmantojot Bauer-KirbyTM disku difūzijas testu un MIC, lietojot ETM-testu. 3. Tipēt izdalīto bakt…
Risk factors for cystic fibrosis arthropathy: Data from the German cystic fibrosis registry
2021
Epidemiology and potential risk factors for cystic fibrosis arthropathy (CFA) were studied in a relevant cystic fibrosis (CF) patient cohort.Cohort study of patients included in the German CF registry in 2016-2017. Descriptive analysis, exploratory tests and multivariable logistic regression were used to assess prevalence of CFA and associated potential risk factors for adult patients with/without chronic Pseudomonas aeruginosa infection.6069 CF patients aged from 0 to 78 years were analysed. CFA was observed in 4.9% of the patients. Prevalence was significantly higher in adult patients (8.4%) compared to patients18 years (0.7%; p0.0001). Logistic regression analyses in adult patients (n=33…
Spreading of sudomotor axon reflexes in human skin.
2005
Acetylcholine (ACh) activates both sudomotor fibers and primary afferent nociceptors. This leads to sudomotor and vasodilator axon reflexes, which can be diminished, for example, in neuropathies. In some neuropathies, however, there is increased axon reflex sweating, a response pattern that has never been observed for vasodilator flares.To compare both types of axon reflexes and to elucidate possible differences.In healthy young male subjects, sweat response and flare reaction in response to ACh were quantified. Constant-current iontophoresis (300 mC) of ACh was performed on the lateral lower legs. The sudomotor axon reflex was visualized with iodine starch staining, and the sweat response …
Somatotopic arrangement of sudomotor axon reflex sweating in humans
2005
Impaired sweating may be one of the first symptoms in neuropathies, and therefore the evaluation of sweating might facilitate their early detection. Sudomotor axon reflexes can be quantified by two different methods: quantitative sudomotor axon reflex testing (QSART) measures the amount of local sweating, whereas staining with the iodine starch reaction assesses the extension of the sudomotor axon reflex area. The aim of our study was to compare both tests at three different sites on the leg: foot, lower leg and thigh.QSART and iodine starch staining after iontophoretic stimulation with acetylcholine were performed on 15 male volunteers (mean age: 25; range 24-27 years) on the left resp. th…
Botulinum toxin A (Botox) and sweating-dose efficacy and comparison to other BoNT preparations.
2004
Abstract Background Botulinum toxin type A (BoNT/A) is 20–50 times more effective than Botulinum toxin type B (BoNT/B) concerning the treatment of muscular hypercontractions [Sloop, R.R., Cole, B.A., Escutin, R.O., 1997. Human response to botulinum toxin injection: type B compared with type A. Neurology 49, 189–194]. Botulinum toxins block motor nerves as well as autonomic fibres [Rand, M.J., Whaler, B.C., 1965. Impairment of sympathetic transmission by botulinum toxin. Nature 206, 588–591]. Objective Purpose of this study was to analyse the dose dependent reduction of sweating using the BoNT/A preparation Botox® and to compare the results with our earlier results analysing Dysport® [Braune…
Chemically and electrically induced sweating and flare reaction
2004
Both thin afferent (nociceptors) and efferent (sympathetic sudomotor) nerve fibers can be activated electrically and chemically, resulting in neurogenic erythema and sweating. These reactions have been used before to assess the impairment of sympathetic and nociceptor fibers in humans. In this study, electrically induced sweating and erythema were assessed simultaneously in the foot dorsum and thigh, and were compared to chemically induced activation. Reproducible intensity-response relations (stimulation intensities 0-30 mA, 1 Hz) were obtained from 32 subjects. The steepest increase of the sweat response was induced at lower intensities as compared to that of the erythema (18.3 mA vs. 25.…
Botulinum Toxin A reduces neurogenic flare but has almost no effect on pain and hyperalgesia in human skin.
2003
Botulinum toxin A (BoNT/A) has been used therapeutically to treat muscular hypercontractions and sudomotor hyperactivity. There is increasing evidence that BoNT/A might also have analgesic properties, in particular in headache. In the present investigation we tested the often cited hypothesis that BoNT/A-induced analgesia can be attributed to inhibition of neuropeptide release from nociceptive nerve fibers. In 15 healthy volunteers BoNT/A (5, 10, 20 mouse units BOTOX) or saline (contralateral side) was injected intracutaneously on the volar forearm. On day zero, the day of injection, no further tests were performed. We repeatedly elicited pain, mechanical hyperalgesia and neurogenic flare b…
Sudomotor testing predicts the presence of neutralizing botulinum A toxin antibodies.
2002
The increasing number of patients being treated with botulinum toxin A complex (BoNT/A) has led to a higher incidence of neutralizing anti-BoNT/A antibodies (ABAs). Because BoNT/A is known to inhibit sweating, here we report sudometry as a possibility for predicting the presence of ABA. Sixteen patients suffering from spasmodic torticollis were selected: in 2 patients, BoNT/A treatment continued to be effective, in 9 patients, the treatment effect was impaired, and in 5 patients, secondary treatment failure developed. BoNT/A (100 mouse units, Dysport; Ipsen Pharma, Berkshire, United Kingdom) was injected subcutaneously into the lateral calves. Sweating was visualized with iodine starch stai…
Comparison of the sympathetic skin response and continuous wave Doppler sonography of the radial artery.
1999
The value of neurophysiological tests of the autonomic nerve system is limited. One of the clinically most commonly applied test is the skin sudomotor response, frequently referred to as 'sympathetic skin response' (SSR). However, the SSR is a more qualitative than quantitative evaluation technique. Continuous wave (cw) Doppler sonography of the radial artery may be an alternative quantitative approach. We studied 41 age matched volunteers (23 female, 18 male; 16-82 years (mean age 53 years)). The stimulus was a loud and unexpected acoustic signal, alternatively a cough. SSR evaluation included the latency of onset, the duration and the amplitude of the response. Doppler evaluation also inc…
Ceftolozane Pharmacokinetics in a Septic Critically Ill Patient under Different Extracorporeal Replacement Therapies
2019
Ceftolozane-tazobactam (C/T), a novel fifth-generation cephalosporin/β-lactamase inhibitor combination active against multidrug-resistant (MDR) Pseudomonas aeruginosa, is currently approved by the U.S. Food and Drug Administration (FDA) to treat complicated intra-abdominal and urinary tract