Search results for "Dopamine"
showing 10 items of 660 documents
Opposite effects of dopamine on the mechanical activity of longitudinal and circular muscles in human colon
2015
Objective: Dopamine (DA) has been proposed to act as a modulator of GI motility, via activation of specific receptors D1- and D2-like receptors widely expressed throughout the length of the gastrointestinal tract, in different animal species. However, little and not clear information are available about DA effect in the human gut. The aims of this study were to elucidate whether dopamine may affect contractility in human colon, the receptor subtypes involved and the possible differences in the function and distribution of dopaminergic receptors between longitudinal and circular muscle. Methods: Mechanical responses to dopamine were examined in vitro as changes in isometric tension in strips…
Dopaminergic agents acting at D1 and D2 receptor sites differently affect melatonin synthesis in rat pineal gland during night.
2001
A new dopamine amino-acid conjugate: preclinical in vitro studies and evaluation of behavioural effects in rats
2012
It is well established that alterations in the functionality of dopaminergic transmission are associated with neurodegenerative diseases such as Parkinson’s Disease. The purpose of this study was to investigate the activity of a new dopamine amino-acid conjugate: L-phenylalanine-β-(3,4-dihydroxyphenyl) etilamide(DA-Phe) in the central nervous system, by assessing its influence on different behavioural parameters in the rat. Preliminarily, we tested the in vitro stability in plasmatic environment following the disappearance of DA-Phen from human plasma and the concurrent appearance of dopamine. Using rat brain homogenate, we also evaluated the level of DA-Phen cleavage by cerebral enzymes an…
Potential dopamine prodrug-loaded liposomes: preparation, characterization and in vitro stability studies
2009
FABBRICAZIONE DI SENSORI ELETTROCHIMICI NANOSTRUTTURATI PER APPLICAZIONI NELL’INDUSTRIA ALIMENTARE E BIOMEDICHE
2023
DOPAMINE ELECTROCHEMICAL SENSOR BASED ON REDUCED GRAPHENE OXIDE AND METAL NANOPARTICLES
2019
Dopamine (DA) is one of the most important neurotransmitters released from the brain, and is involved in many different biological processes. This neurotransmitter influences the processes that involve memory, sleep, mood, learning, and so on. Besides, in the last years, dopamine concentration in human body fluids has been related to some neurodegenerative pathologies, such as Parkinson and Alzheimer’s diseases [1]. It is well known that these pathologies are due to the formation of amyloids plaques that block part of the brain. Many literature data reports that DAergic neurons (areas of midbrain where DA is synthesized) shows a different activity when amyloid plaques are present with a con…
TERMODINAMICA, CAMPI QUANTICI E FUNZIONI MENTALI
2010
Nel tentativo di fornire spiegazioni esaurienti sul fenomeno della mente umana, il presente saggio scientifico di anatomia comparata e di fisiologia considera alcune tesi di fondo che si collegano a nuovi parametri fisici della realtà che ci circonda.
Cooperative Catechol-Functionalized Polypept(o)ide Brushes and Ag Nanoparticles for Combination of Protein Resistance and Antimicrobial Activity on M…
2018
Prevention of biofouling and microbial contamination of implanted biomedical devices is essential to maintain their functionality and biocompatibility. For this purpose, polypept(o)ide block copolymers have been developed, in which a protein-resistant polysarcosine (pSar) block is combined with a dopamine-modified poly(glutamic acid) block for surface coating and silver nanoparticles (Ag NPs) formation. In the development of a novel, versatile, and biocompatible antibacterial surface coating, block lengths pSar were varied to derive structure-property relationships. Notably, the catechol moiety performs two important tasks in parallel; primarily it acts as an efficient anchoring group to me…
Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter
2001
6-Methoxylated and 8-oxygenated benztropines were prepared and evaluated for their DAT and SERT activity (binding and uptake inhibition). Methoxylation at the two-carbon bridge of benztropine produced a novel class of potent and selective DAT ligands. An interesting enantioselectivity was also observed for this new class of chiral benztropines. The inactivity of the 8-oxygenated analogues seems to point out that, unlike cocaine and its analogues, interactions of benztropine ligands with DAT may be strongly governed by the nitrogen atom.
In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine rece…
2007
Abstract Benzamide derivatives as radiotracers have played an important role in diagnosing malfunction in dopaminergic neurotransmission. A variety of halogenated and two unsubstituted benzamide derivatives were synthesised and their in vitro affinities to dopaminergic, serotonergic and adrenergic receptors and their lipophilicities were determined. As references IBZM (3), raclopride (4) and FLB457 (5) were tested as well. The two iodinated compounds NAE (27) and NADE (28) displayed Ki values of 0.68 and 14 nM for the D2 receptor. The well-established radiotracers FP (1) and DMFP (2) showed affinities in the same range as did the brominated compounds NABrE (29) and NABrDE (30). The log D7.4…