Search results for "Dose dependence"

showing 3 items of 13 documents

Dose-dependent metabolism and hepatic distribution of phenprocoumon in rats

1988

The dose-dependency of phenprocoumon disposition was determined in rats by iv administration of 0.1 and 1.0 mg/kg doses to separate groups of animals. The intrinsic clearance (unbound clearance) was 33% lower in the animals given 1.0 mg/kg dose than in the animals given 0.1 mg/kg dose. The apparent unbound volume of distribution was 55% lower and the elimination rate constant 54% higher in the high dose group than in the lower dose group. Binding of phenprocoumon to liver showed saturability with a two- to threefold higher apparent unbound fraction of phenprocoumon in liver in animals given the high dose in comparison to animals given the low dose.

Malemedicine.medical_specialtymedicine.drug_classDose dependencePhenprocoumonPharmacokineticsElimination rate constantInternal medicinemedicineAnimalsDistribution (pharmacology)Tissue DistributionPharmacology (medical)General Pharmacology Toxicology and PharmaceuticsVolume of distributionDose-Response Relationship DrugChemistryAnticoagulantRats Inbred Strains4-HydroxycoumarinsMetabolismRatsEndocrinologyLiverInjections IntravenousPhenprocoumonCarrier Proteinsmedicine.drugJournal of Pharmacokinetics and Biopharmaceutics
researchProduct

Effects on arterial blood pressure of the methanol extracts from differentTeucriumspecies

1997

Methanol extracts of the leaves and stems of two Teucrium species (T. pumillum L. and T. buxifolium L.) have been tested for their effects on resting arterial blood pressure. Both T. pumillum L. and T. buxifolium L. extracts reduced mean arterial blood pressure in a dose dependent manner when administered i.v. to urethane anaesthetized normotensive rats. © 1997 John Wiley & Sons, Ltd.

PharmacologybiologyTraditional medicinebusiness.industryHypotensive drugDose dependencePharmacognosybiology.organism_classificationTeucriumchemistry.chemical_compoundBlood pressurechemistryTeucrium pumilumMedicineLamiaceaeMethanolbusinessPhytotherapy Research
researchProduct

Dose-dependent osteoinductive effects of bFGF in rabbits.

2009

Growth factors lead to the induction of tissue regeneration in bone healing when coated on biomaterials. Basic fibroblast growth factor (bFGF) combines osteoinduction and neoangiogenesis. This study evaluated bFGF-coated hydroxylapatite implants in two experimental groups with 10 or 100 microg (n = 5 per group) compared with uncoated control implants in the rabbit patellar groove model. We observed an unexpected ineffectiveness compared to the control groups with no significant difference of bone growth after 35 days. However, all samples from the 100 microg experiment (control and coated implant) showed significantly stronger 19-25 day label than both 10 microg groups (control and coated i…

medicine.medical_specialtyBone RegenerationClinical BiochemistryBasic fibroblast growth factorDose dependenceBone healingchemistry.chemical_compoundEndocrinologyCoated Materials BiocompatibleImplants ExperimentalOsteoclastInternal medicinemedicineAnimalsHumansBone growthDose-Response Relationship DrugHistologyCell BiologyPatellaHydroxylapatiteSurgerymedicine.anatomical_structureEndocrinologyDurapatiteTreatment OutcomechemistryModels AnimalFibroblast Growth Factor 2ImplantRabbitsGrowth factors (Chur, Switzerland)
researchProduct