Search results for "Dose"
showing 10 items of 2247 documents
Breath test using 13C methacetin does not seem to be useful in the assessment of liver function in girls with anorexia nervosa: a case control study
2018
Abstract Background Anorexia nervosa (AN) concerns approximately up to 1.8% of the pediatric female population. One of the complications that can occur in the course of this disease is acute liver failure. This study’s objective was to assess the usefulness of the 13C labeled Methacetin Breath Test (MBT) in the diagnostics of the liver function in girls with eating disorders. Methods For the study 81 girls aged 12 to 17 years were recruited, including 41 patients with confirmed diagnosis of AN (mean age 14.7 ± 1.48 years) and 40 age-matched controls. The diagnosis was based on the present Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria. Weight and height were measured…
18-hydroxylation in the Y-1 adrenal cell line: response to ACTH and to culture conditions.
1992
The 18-hydroxylation of deoxycorticosterone in the Y-1 adrenal cell line was studied under various incubation and cell culture conditions and compared to 11 beta-hydroxylation. Repeated incubation of the substrate increased both 18- and 11 beta-hydroxylation in the Y-1 cells. Furthermore, both 18- and 11 beta-hydroxylation were increased with increased serum concentration and prolonged incubation time. While the increase in 11 beta-hydroxylation seemed to be independent of the type of serum, 18-hydroxylation was much more important in cells cultured in fetal or newborn calf serum supplemented medium than in those cultured in horse serum supplemented medium. As expected, ACTH treatment incre…
Peritoneal cavity phagocytes from the teleost sea bass express a glucocorticoid receptor (cloned and sequenced) involved in genomic modulation of the…
2005
Abstract To gain further insight into the role of cortisol in Wsh innate immune responses, we cloned and sequenced a 2592 bp cDNA from sea bass (Dicentrarchus labrax) peritoneal leukocytes (PCLs) encoding a glucocorticoid receptor (DlGR1). The deduced aminoacid sequence displayed that DlGR1 belong to a multigenic family of steroid hormone receptors, and exhibited high homology (80%) to the Burton’s mouth breeder (Haplochromis burtoni) HbGR1. The DlGR1 functional domains presented homologies with those of several vertebrate species. In situ hybridization assay revealed that DlGR1 was expressed in macrophages and neutrophils from the peritoneal cavity. Since in a previous paper, sea bass PCL …
Effects of nicotine receptor agonists on acetylcholine release from the isolated motor nerve, small intestine and trachea of rats and guinea-pigs
1992
The effects of nicotine receptor agonists on the release of [3H]acetylcholine from the phrenic nerve, the small intestine and the trachea were investigated to characterize neuronal nicotine receptors within the peripheral nervous system. Contraction of the indirectly-stimulated hemidiaphragm was recorded to investigate desensitization of the postsynaptic muscular nicotine receptors. Nicotine, cytisine, 1,1-dimethyl-4-phenylpiperazinium and 2-(4-aminophenyl)-ethyl-trimethyl-ammoniumiodide caused a concentration-dependent (0.1-30 microM) increase in evoked [3H]acetylcholine release from the phrenic nerve, whereby bell-shaped concentration-response curves were obtained. The rank order of decre…
D1 receptors play a major role in the dopamine modulation of mouse ileum contractility
2010
Since the role of dopamine in the bowel motility is far from being clear, our aim was to analyse pharmacologically the effects of dopamine on mouse ileum contractility. Contractile activity of mouse ileum was examined in vitro as changes in isometric tension. Dopamine caused a concentration-dependent reduction of the spontaneous contraction amplitude of ileal muscle up to their complete disappearance. SCH-23390, D1 receptor antagonist, which per se increased basal tone and amplitude of spontaneous contractions, antagonized the responses to dopamine, whilst sulpiride or domperidone, D2 receptor antagonists, were without effects. The application of both D1 and D2 antagonists had additive effe…
SU-FF-T-13: Monte Carlo Calculation of the TG-43 Dosimetric Parameters of a New BEBIG Ir-192 HDR Source
2005
Purpose: High dose rate (HDR) brachytherapy is a highly extended practice in clinical brachytherapy today. Quality dose rate distribution datasets of the HDR sources used in a clinical treatment are required. Because of the different source designs, a specific dosimetry dataset is required for each source model. In the recently published BRAPHYQS-ESTRO Report, an overview of available dosimetric data for all HDR Ir-192 sources is given, pointing out the lack of data for one of the sources, the used by the BEBIG MultiSource afterloading system (BEBIG GmbH, Germany). The purpose of this study is to obtain detailed dose rate distributions in liquid water media around this source. Material and …
SU-FF-T-329: Monte Carlo Dosimetric Study of the Flexisource Ir-192 HDR Source
2006
Purpose:Brachytherapy with high dose rate (HDR) sources of 192 Ir is a usual practice in clinical brachytherapy today. The TG43 U1 update report recommends that accurate dose distribution data of the brachytherapysource in use should be obtained experimentally or by Monte Carlo (MC), to be used as input in the HDR Treatment Planning System (TPS). The purpose of this study is to obtain the dose rate distribution in liquid water media for the Flexisource HDR 192 Ir source (Isodose Control GmbH, Germany) using the Monte Carlo method to obtain the TG43 U1 parameters and the 2‐D rectangular dose rate table. Material and methods: The MC code GEANT4 (7.1 version) was used to estimate dose rate in …
Implementation and Validation of an End-to-End Commissioning Process for Model-Based Dose Calculation Algorithms in Brachytherapy
2016
WE-C-141-01: Research and Relevance of Brachytherapy Dose Calculation Advancements
2013
Research and Relevance of Brachytherapy Dose Calculation Advancements Organizer: Mark J. Rivard Moderator: Geoffrey S. Ibbott Speakers: Facundo Ballester, Asa Carlsson Tedgren, Firas Mourtada Brachytherapy dosimetry is undergoing a renaissance with the scrutiny of the AAPM TG‐43 dose calculation formalism and comparisons with alternate approaches such as the Monte Carlo method, the grid‐based Boltzmann solvers, and the collapsed‐cone technique. Treatment planning systems (TPS) using these more advanced, model‐based dose calculation algorithms (MBDCAs) are now available for clinical use. However, their accuracy and the preferred method for their use have not been established. Thus, it is imp…