Search results for "Dose"

Duodenal contractile activity in dystrophic (mdx) mice: reduction of nitric oxide influence.

2003

The present study was undertaken to analyse duodenal contractility in adult dystrophic (mdx) mice. The spontaneous changes of the isometric tension and the responses of longitudinal duodenal muscle to nonadrenergic, noncholinergic (NANC) nerve stimulation and to exogenous drugs were compared between normal and mdx mice. Duodenal segments from mdx mice displayed spontaneous contractions with higher frequency than normals. N omega-nitro-L-arginine methyl ester (L-NAME) increased the frequency of contractions in normals without affecting that in mdx mice. In normals, NANC nerve stimulation elicited a transient relaxation abolished by L-NAME. In mdx mice a frank relaxation was not observed, the…

Mucopolysaccharidoses and other lysosomal storage diseases.

2013

Mucopolysaccharidosis and other lysosomal storage diseases are rare, chronic, and progressive inherited diseases caused by a deficit of lysosomal enzymes. Patients are affected by a wide variety of symptoms. For some lysosomal storage diseases, effective treatments to arrest disease progression, or slow the pathologic process, and increase patient life expectancy are available or being developed. Timely diagnosis is crucial. Rheumatologists, orthopedics, and neurologists are commonly consulted due to unspecific musculoskeletal signs and symptoms. Pain, stiffness, contractures of joints in absence of clinical signs of inflammation, bone pain or abnormalities, osteopenia, osteonecrosis, secon…

Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis.

2008

Contains fulltext : 70589.pdf (Publisher’s version ) (Closed access) OBJECTIVE: CO-releasing molecules (CO-RMs) are a novel class of anti-inflammatory agents. We have examined the possible therapeutic effects of CORM-3 in collagen-induced arthritis (CIA). METHODS: Arthritis was induced in DBA-1/J mice by type II collagen. Animals were treated with CORM-3 (5 and 10 mg/kg/day, intraperitoneally) or the inactive compound iCORM-3 (10 mg/kg/day, intraperitoneally) unable to release CO, from days 22 to 31. Production of anti-type II collagen antibodies, cytokines and cartilage olimeric matrix protein (COMP) was evaluated by enzyme-linked immunosorbent assay, and prostaglandin E(2) (PGE(2)) by rad…

Antineoplastic dosing in overweight and obese cancer patients: an Associazione Italiana Oncologia Medica (AIOM)/Associazione Medici Diabetologi (AMD)…

2021

Most anticancer molecules are administered in body-size-based dosing schedules, bringing up unsolved issues regarding pharmacokinetic data in heavy patients. The worldwide spread of obesity has not been matched by improved methods and strategies for tailored drug dosage in this population. The weight or body surface area (BSA)-based approaches may fail to fully reflect the complexity of the anthropometric features besides obesity in cancer patients suffering from sarcopenia. Likewise, there is a lack of pharmacokinetic data on obese patients for the majority of chemotherapeutic agents as well as for new target drugs and immunotherapy. Therefore, although the available findings point to the …

On-Line Characterization of Gamma Radiation Effects on Single-Ended Raman Based Distributed Fiber Optic Sensor

2016

We report distributed temperature measurements based on Raman scattering performed during steady state $\gamma $ -ray irradiation at a dose rate of 1 kGy( ${\rm SiO}_{2}$ )/h and up to a total ionizing dose (TID) of $\sim 0.1\ \hbox{MGy}$ . We characterize on-line the evolution of the performances of a single-ended Raman distributed temperature sensor (RDTS) during the $\gamma $ -ray exposure of different classes of commercial multimode fibers (MMFs) acting as the sensing element. RDTS is influenced by the radiation-induced attenuation (RIA) phenomena leading to both large errors in the temperature measurements and a diminution of the useful sensing length. The amplitude of the radiation-in…

Oxymetazoline modulates proinflammatory cytokines and the T‐cell stimulatory capacity of dendritic cells

2007

The nasal decongestant oxymetazoline (OMZ) is frequently used in the topical treatment of rhinitis/sinusitis. As proinflammatory cytokines play a critical role in the development and maintenance of local inflammation, the aim of this study was to investigate the influence of OMZ on immune cells in order to diminish the mucosal infiltration of the nose. Peripheral blood mononuclear cells (PBMC) from buffy coats of healthy volunteers were isolated and stimulated in the presence or absence of OMZ. In addition, monocyte-derived dendritic cells (DC) were generated and different concentrations of OMZ were added. DC phenotype and their T-cell stimulatory properties were analysed. The vasoactive su…

Hormesis: Decoding Two Sides of the Same Coin

2015

In the paradigm of drug administration, determining the correct dosage of a therapeutic is often a challenge. Several drugs have been noted to demonstrate contradictory effects per se at high and low doses. This duality in function of a drug at different concentrations is known as hormesis. Therefore, it becomes necessary to study these biphasic functions in order to understand the mechanistic basis of their effects. In this article, we focus on different molecules and pathways associated with diseases that possess a duality in their function and thus prove to be the seat of hormesis. In particular, we have highlighted the pathways and factors involved in the progression of cancer and how t…

Pediatric radiation doses from multi-detector CT exams: preliminary results from the first 2011 Italian national survey

2012

Radiation protection of patients undergoing high-dose-rate brachytherapy: peripheral dose estimation, review of radiation risks and implant shielding…

2015

La braquiterapia (BT) es una modalidad de tratamiento de radioterapia en la que se coloca una fuente radiactiva encapsulada cerca, en contacto o en el interior del volumen a tratar. La desintegración de esta fuente produce la emisión de energía, lo que puede dar lugar a la muerte celular. Una dosis absorbida muy elevada (la dosis absorbida se define como la energía absorbida por unidad de masa) se deposita en un corto período de tiempo y en un pequeño número de fracciones. Para poder realizar un tratamiento de BT se requiere que el volumen de tratamiento sea accesible y bien delimitado en tamaño y forma. La BT se utiliza comúnmente como una modalidad de tratamiento eficaz para el cáncer de …

Exposition continue à des mélanges de perturbateurs endocriniens

2012

Dans ce projet, il est question d’explorer les effets de mélanges de perturbateurs endocriniens sur plusieurs générations, en considérant des cibles différentes (appareil reproducteur, glande mammaire, os, dent, tissu adipeux, glandes salivaires, cerveau...) et adaptées à chaque âge pour essayer de mieux comprendre comment agissent des perturbateurs endocriniens, en particulier ceux qui interfèrent avec les hormones sexuelles. Parmi les questions majeures que se pose le scientifique, figurent celles de l’effet d’une exposition prolongée à des mélanges de perturbateurs endocriniens depuis la conception jusqu’à l’âge adulte, et de la possibilité que ces expositions aient des répercussions sur…