Search results for "Down"
showing 10 items of 1658 documents
Azithromycin Differentially Alters TCR-Activated Helper T Cell Subset Phenotype and Effector Function
2020
In addition to their antibiotic activities, azithromycin (AZM) exhibits anti-inflammatory effects in various respiratory diseases. One of the potent anti-inflammatory mechanisms is through inhibition of CD4+ helper T (Th) cell effector function. However, their impact on specific Th subset is obscure. Herein, we demonstrate the cellular basis of phenotypic and functional alterations associated with Th subsets following AZM treatment in vitro. Using well-characterized Th subset specific chemokine receptors, we report significant suppression of T cell receptor (TCR)-stimulated hyperactivated CCR4+CXCR3+ (Th0) expansion compared to CCR4-CXCR3+ (Th1-like) and CCR4+CXCR3- (Th2-like) cells. Intere…
Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes
2021
Myeloid cell arginase-mediated arginine depletion with consecutive inhibition of T cell functions is a key component of tumor immune escape. Both, granulocytic myeloid-derived suppressor cells (G-MDSC) and conventional mature human polymorphonuclear neutrophil granulocytes (PMN) express high levels of arginase 1 and can act as suppressor cells of adaptive anti-cancer immunity. Here we demonstrate that pharmacological inhibition of PMN-derived arginase 1 not only prevents the suppression of T cell functions but rather leads to a strong hyperactivation of T cells. Human PMN were incubated in cell culture medium in the absence or presence of an arginase inhibitor. T cells from healthy donors w…
Vγ9Vδ2 T cells as a promising innovative tool for immunotherapy of hematologic malignancies
2011
The potent anti-tumor activities of γδ T cells, their ability to produce pro-inflammatory cytokines, and their strong cytolytic activity have prompted the development of protocols in which γδ agonists or ex vivo-expanded γδ cells are administered to tumor patients. γδ T cells can be selectively activated by either synthetic phosphoantigens or by drugs that enhance their accumulation into stressed cells as aminobisphosphonates, thus offering new avenues for the development of γδ T cell-based immunotherapies. The recent development of small drugs selectively activating Vγ9Vδ2 T lymphocytes, which upregulate the endogenous phosphoantigens, has enabled the investigators to design the experiment…
Resveratrol, MicroRNAs, Inflammation, and Cancer
2011
MicroRNAs are short noncoding RNAs that regulate the expression of many target genes posttranscriptionally and are thus implicated in a wide array of cellular and developmental processes. The expression ofmiR-155ormiR-21is upregulated during the course of the inflammatory response, but these microRNAs are also considered oncogenes due to their upregulation of expression in several types of tumors. Furthermore, it is now well established that inflammation is associated with the induction or the aggravation of nearly 25% of cancers. Therefore, the above microRNAs are thought to link inflammation and cancer. Recently, resveratrol (trans-3,4′,5-trihydroxystilbene), a natural polyphenol with ant…
Siinä pitää kyllä olla vähä teflonii : tunnekokemuksia johtajana irtisanomistilanteessa
2017
The world of leadership has often been considered a callous world characterized at best only by masculine feelings, such as aggressiveness. In addition, leadership has traditionally been considered an influential skill of individuals. In this study, leadership was examined as a socially constructed phenomenon that develops as a result of interaction between leaders and their subordinates and that cannot be separated from the framework in which it takes place. The target phenomena in the present study were leaders’ emotional experiences related to those who were being dismissed. The main research task was to conduct an empirical study on leaders’ experiences as parties giving notices and ana…
Interpersonal work resources and school personnel well-being before and after lockdown during the first phase of the COVID-19 pandemic in Finland
2022
This two-wave mixed-methods study used the job demands and resources model to examine the effects of the COVID-19 pandemic on school personnel's work well-being (including burnout, work engagement, and sense of belonging) in spring 2020 in Finland in particular with respect to collegial relationships (respectful engagement) and leadership support. A pre-lockdown survey was administered prior to the pandemic (in January–February, n = 437) and a post-lockdown survey was administered after the two-month lockdown (at the end of May, n = 270). At post-lockdown, the school personnel reported, on average, more exhaustion, less work engagement (measured as enthusiasm and energy at work), and a decr…
Selection of Membrane RNA Aptamers to Amyloid Beta Peptide: Implications for Exosome-Based Antioxidant Strategies
2019
The distribution of amyloid beta peptide 42 (Aβ42) between model exosomal membranes and a buffer solution was measured. The model membranes contained liquid-ordered regions or phosphatidylserine. Results demonstrated that up to ca. 20% of amyloid peptide, generated in the plasma (or intracellular) membrane as a result of proteolytic cleavage of amyloid precursor proteins by β- and γ-secretases, can stay within the membrane milieu. The selection of RNA aptamers that bind to Aβ42 incorporated into phosphatidylserine-containing liposomal membranes was performed using the selection-amplification (SELEX) method. After eight selection cycles, the pool of RNA aptamers was isol…
Coffee Restores Expression of lncRNAs Involved in Steatosis and Fibrosis in a Mouse Model of NAFLD
2021
Background and aim: Coffee intake exerts protective effects against non-alcoholic fatty liver disease (NAFLD), although without fully cleared mechanisms. In this study we aimed to assess whether coffee consumption may influence the expression of long non-coding RNAs (lncRNAs) in the liver. Methods: C57BL/6J mice were fed a 12-week standard diet (SD), high-fat diet (HFD) or HFD plus decaffeinated coffee solution (HFD + coffee). Expression of specific lncRNAs involved in NAFLD was analyzed by real-time PCR. For the most differentially expressed lncRNAs, the analysis was also extended to their mRNA targets. Results: Decaffeinated coffee intake reduced body weight gain, prevented NAFLD, lowered…
Replication Data for: Who can go back to work when the COVID-19 pandemic remits?
2020
The file contains the raw data that was used to make the calculations in the article "Who can go back to work when the COVID-19 pandemic remits?" and that allows to replicate it. Specifically, it contains the following: Corresponding to Social Security in Spain - Affiliates to Social Security in Spain in the month of February 2020, distributed by age and province. - Affiliates by sectors in the different regimes, distributed by provinces. February 2020. - Grouping of sectors according to the National Classification of Economic Activities. Corresponding to the effects of covid-19 - Cases and deaths by age in Spain on April 21, 2020 - Population in Spain by age - Total cases and dea…
Anglicisms and Italian Equivalents in the Era of Covid-19: A Corpus-Based Study of Lockdown
2020
The whole globe has been going through an unprecedented historical moment since World War II. COVID-19, the disease against which we have all been trying to defend ourselves for several months now, has spread worldwide with a significant impact in all spheres of life. With the pandemic outburst and English the language of globalization, several Anglicisms have entered the lexicon of other languages, especially Italian, traditionally open to foreign words. COVID-19-related Anglicisms are used in Italian to such an extent that we can reasonably refer to them as the ‘language of pandemic’. The English words and expressions employed in Italian to refer to the current disease are numerous. Some …