Search results for "Down"
showing 10 items of 1658 documents
Comparison between unrestricted dynamic shakedown design and a new probabilistic approach for structures under seismic loadings
2014
The paper concerns a study related to the comparison between two different approaches utilized for the formulation of an optimal shakedown design problem for elastic plastic frame structures subjected to a combination of fixed and seismic loading. The first formulation utilizes the unrestricted dynamic shakedown theory, while the second one is based on a new probabilistic approach. The comparison is effected in terms of mathematical formulations, in terms of adopted loading models and in terms of numerical results. The performed applications are related to plane steel frames.
Szczegóły konstrukcyjne organów Paula Voelknera na przykładzie unikalnego katalogu firmowego z 1900 roku
2018
This article presents a unique advertising brochure dating from 1900 which was published by the organ building company Voelkner from Duninów and which has been discovered in the State Archives in Wrocław in the files of the Silesian Evangelical Consistory. The catalogue contains 47 pages and is a valuable source for the history of the Voelkner company. By studying this publication, the reader will get acquainted with the trends prevailing in the field of organ building at the turn of the 19th to the 20th centuries. However, the advertising folder does not contain any listing of the works realized by the company, which is probably its greatest shortcoming.
Organy na Śląsku Opolskim na łamach „Zeitschrift für Instrumentenbau”
2021
Periodicals remain a valuable source of information about the history of Silesian organ building. Particularly from the nineteenth century on, numerous publications appeared in the general press that were dedicated to music and the various manifestations of musical life including issues from the field of instrumentology. Professional periodicals dealing with this topic also started to appear. The periodical “Zeitschrift für Instrumentenbau”, which was founded by Paul de Wit in 1880 and appeared until 1943, certainly belonged to this group of publications. It devoted much space to the issues of organ building. Starting from the thirteenth year of publication, it included even a permanent sec…
Organy - instrument, który "oddycha"
2016
Artykuł omawia organy jako instrument z rodziny aerofonów. Punktem wyjścia do przeprowadzenia analiz jest niewielka tabliczka informująca kalikanta o należytym wykonywaniu pracy, która znajduje się na chórze muzycznym kościoła parafialnego pw. Najświętszego Serca Pana Jezusa w Roszkowie (pow. Racibórz). Tego rodzaju instrukcje były typowe dla organów pochodzących z warsztatu organmistrzowskiego Schlag & Söhne. W artykule omówiona jest funkcja kalikanta. Artykuł stawia tezę o konieczności przywrócenia organom ich „aerofoniczności”. Przedłożone zostały trzy postulaty końcowe: 1) Należy wyposażać nowo budowane organy w mechanizmy do kalikowania — uzupełnieniem zaś tego rodzaju urządzeń powinny…
Organy w kościołach diecezji świdnickiej. Budowa nowych instrumentów i działania konserwatorskie w latach 2004-2014
2016
The Diocese of Świdnica has existed since 2004. So far, only one pipe organ has been built in its territory. In 2005 the Wrocław-based Cynar company performed the installation of a 38-voice instrument with an electronic action for the Church of the Elevation of the Holy Cross in Kłodzko. For its construction the company used the organ of a deconsecrated church in Germany, i.e. St. Peter’s Church in Frankfurt am Main. In other newly-built churches electronic instruments have been installed, mainly for financial reasons. Since the diocese was founded 10 years ago, 25 instruments have undergone thorough renovation. An important event was the general renovation of the 50-voice organ in the basi…
Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS.
2005
Phosphorylated p38 mitogen-activated protein kinase (p38MAPK), but not activated c-jun-N-terminal kinase (JNK), increases in the motor neurons of transgenic mice overexpressing ALS-linked SOD1 mutants at different stages of the disease. This effect is associated with a selective increase of phosphorylated MKK3-6, MKK4 and ASK1 and a concomitant upregulation of the TNFalpha receptors (TNFR1 and TNFR2), but not IL1beta and Fas receptors. Activation of both p38 MAPK and JNK occurs in the activated microglial cells of SOD1 mutant mice at the advanced stage of the disease; however, this effect is not accompanied by the concomitant activation of the upstream kinases ASK1 and MKK3,4,6, while both …
Apollon gene silencing induces apoptosis in breast cancer cells via p53 stabilisation and caspase-3 activation
2009
We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted in a marked, time-dependent decline of cell growth and an increased rate of apoptosis, which was associated with p53 stabilisation and activation of the mitochondrial-dependent apoptotic pathway. Pre-incubation of cells with a p53-specific siRNA resulted in a partial rescue of cell growth inhibition, as well as in a marked reduction of the apoptotic response, indicating p53 as a major player in …
Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma
2018
Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to existing therapies, most probably due to its extraordinary inter- and intra-tumor molecular heterogeneity. The modest therapeutic response to molecular targeted agents underlines the need for new therapeutic approaches for HCC. In our study, we took advantage of well-characterized human HCC cell lines, differing in transcriptomic subtypes, DNA mutation and amplification alterations, reflecting the heterogeneity of primary HCCs, to provide a preclinical evaluation of the specific heat shock protein 90 (HSP90) inhibitor AUY922 (luminespib). Indeed, HSP90 is highly expressed in different tumor types, but it…
Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits
2014
In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48, via the editing of a single nucleotide in the APOB mRNA by the APOBEC1 enzyme. The APOB48 protein is mandatory for the synthesis of chylomicrons by intestinal cells to transport dietary lipids and cholesterol. We produced transgenic rabbits expressing permanently and ubiquitously a small hairpin RNA targeting the rabbit APOBEC1 mRNA. These rabbits exhibited a moderately but significantly reduced …
Educación y futuro digital
2013
Resumen basado en el de la publicación Se presenta la orientación e intervención de una niña con Síndrome de Down de siete años, durante el curso 2007/2008. Dicho estudio empírico se centró en las prácticas desarrolladas en una sesión de 60 minutos por semana y, posteriormente, dos sesiones de 60 minutos. Durante las sesiones estuvo acompañada por una alumna con alta capacidad como parte de la hipótesis de partida de que la alta capacidad estimulará al alumno con discapacidad. Los resultados mostraron un aumento de la motivación y de la comunicación verbal, además alcanzó parte de los objetivos del curso correspondiente a su edad. ESP