Search results for "Down"
showing 10 items of 1658 documents
Mobile game monetization
2015
Mitä rahallistamis menetelmiä on olemassa mobiilipeleille? Entä mitä täytyy ottaa huomioon sovellettaessa tiettyä rahallistamis menetelmää tiettyyn pelityyppiin? Tässä kandidaatintutkielmassa perehdytään siihen mitä mobiilipelit ovat, mikä on Apple App Store, millaisa eri pelityypepjä on, mitkä ovat eri rahallistamismenetelmät mobiilipeleille ja lopuksi rahallistamismenetelmiä käyttöönotettaessa huomioitavia asioita käsitellään luvun verran. Tukimustuloksena esitellään muutama potenttiaalinen rahallistamismenetelmä. Sekä tehdään selväksi että rahallistamismenetelmän valinta on riippuvainen pelistä. Erilaisilla peleillä ja rahallistamismenetelmillä on eri laatuvaatimukset. What are potential…
Data from: Quantitative PCR primer design affects quantification of dsRNA-mediated gene knockdown
2020
RNA interference (RNAi) is a powerful tool for studying functions of candidate genes in both model and non-model organisms and a promising technique for therapeutic applications. Successful application of this technique relies on the accuracy and reliability of methods used to quantify gene knockdown. With the limitation in the availability of antibodies for detecting proteins, quantitative PCR (qPCR) remains the preferred method for quantifying target gene knockdown after dsRNA treatment . We evaluated how qPCR primer binding site and target gene expression levels affect quantification of intact mRNA transcripts following dsRNA-mediated RNAi. The use of primer pairs targeting the mRNA sequ…
Los procesos inferenciales en lectores con síndrome de Down
2013
The aim of this work is to know if the source of the difficulty in making inferences, readers with Down syndrome, is in access to prior knowledge or constructing ideas from purely textual knowledge (based on Saldaña and Frith, 2002 for autism). Involved a sample of 20 students with Down syndrome and mild mental retardation (mean IQ = 60) and a control group of 20 children without cognitive deficits. They were matched as to their extent read metal age via Prueba de Evaluación del Retraso Lector (average 8 years). We created two experimental situations: a) subjects had to generate inferences based on physical knowledge, b) social inferences about knowledge. The ability to check and reaction t…
Probabilistic Evaluation of the Adaptation Time for Structures under Seismic Loads
2016
Abstract In this paper, a probabilistic approach for the evaluation of the adaptation time for elastic perfectly plastic frames is proposed. The considered load history acting on the structure is defined as a suitable combination of quasi-statical loads and seismic actions. The proposed approach utilizes the Monte Carlo method in order to generate a suitable large number of seismic acceleration histories and for each one the related load combination is defined. Furthermore, for each load combination the related adaptation time is determined, if any, as the optimal one for which the structure is able to shakedown under the unamplified applied actions. A known generalized Ceradini's theorem i…
If you can’t be here, be here. Modalit e strategie della protesta online del movimento Black Lives Matter
2021
Eight minutes and forty-six seconds. This is the time in which the murder of George Floyd, in Minnesota, took place on 25 May 2020. A further act of institutionalized violence – granted, legitimized and overlooked by institutions – that made necessary for the Black Lives Matter (BLM) movement to start a series of protests to draw attention to the abuse of power of a racist and corrupt system that highlights the breakdown of the social pact between people in a society. Beyond the ethical and political significance of the event, our contribution aims to reflect on the forms of occupation of the physical and virtual spaces through which BLM constitutes itself as a movement and organizes confli…
High-gradient accelerating structure studies and their application in hadrontherapy
2013
198 páginas. Tesis doctoral del Departamento de Física Atómica, Molecular y Nuclear, de la Universidad de Valencia.
Levels and Changes of Physical Activity in Adolescents during the COVID-19 Pandemic: Contextualizing Urban vs. Rural Living Environment
2020
The COVID-19 pandemic and the social distancing implemented shortly after influence physical activity levels (PALs). The purpose of this investigation was to evaluate the changes in PAL and factors associated with PALs among Croatian adolescents while considering the impact of community (urban vs. rural living environment). The sample included 823 adolescents (mean age: 16.5 ±
Working as early childhood centre directors and deputies : perspectives from Australia, Finland and Norway
2019
Tämä tutkimus, joka tarkasteli päiväkodin johtajien ja apulaisjohtajien johtajuutta, on toteutettu Australiassa, Suomessa ja Norjassa. Teoreettisesti tutkimus sijoittuu uusliberalistiseen ajatteluun, jonka Sims (2017) kuvaa laajenevasti muokkaavan varhaiskasvatuksen toimintatapoja useissa OECD maissa. Tutkimus on luonteeltaan laadullinen tutkimus ja sen aineistona on osallistujien lyhyt taustakysely, työnkuvien sisällönanalyysi ja yksilöhaastattelut. Tulosten mukaan erilaisuutta työn rakenteissa on sekä kunkin maan sisällä että maiden välillä. Tutkimuksessa havaittiin, että odotukset jokaisen roolista ja siitä, kuinka henkilöt osallistuvat johtajuuteen muovautuvat päiväkotikontekstissa. Aus…
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…
2006
Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…
Molecular Mechanisms of the Blockage of Glioblastoma Motility
2021
Glioblastoma (GBM) is the most common and lethal brain tumor. GBM has a remarkable degree of motility and is able to infiltrate the healthy brain. In order to perform a rationale-based drug-repositioning study, we have used known inhibitors of two small Rho GTPases, Rac1 and Cdc42, which are upregulated in GBM and are involved in the signaling processes underlying the orchestration of the cytoskeleton and cellular motility. The selected inhibitors (R-ketorolac and ML141 for Cdc42 and R-ketorolac and EHT 1864 for Rac1) have been successfully employed to reduce the infiltration propensity of GBM in live cell imaging studies. Complementarily, all-atom simulations have elucidated the molecular …