Search results for "Dox"
showing 10 items of 1345 documents
A multi-phase multi-objective dynamic genome-scale model shows different redox balancing among yeast species in fermentation
2021
ABSTRACTYeasts constitute over 1500 species with great potential for biotechnology. Still, the yeastSaccharomyces cerevisiaedominates industrial applications and many alternative physiological capabilities of lesser-known yeasts are not being fully exploited. While comparative genomics receives substantial attention, little is known about yeasts’ metabolic specificity in batch cultures. Here we propose a multi-phase multi-objective dynamic genome-scale model of yeast batch cultures that describes the uptake of carbon and nitrogen sources and the production of primary and secondary metabolites. The model integrates a specific metabolic reconstruction, based on the consensus Yeast8, and a kin…
Approximated overlap error for the evaluation of feature descriptors on 3D scenes
2013
This paper presents a new framework to evaluate feature descriptors on 3D datasets. The proposed method employs the approximated overlap error in order to conform with the reference planar evaluation case of the Oxford dataset based on the overlap error. The method takes into account not only the keypoint centre but also the feature shape and it does not require complex data setups, depth maps or an accurate camera calibration. Only a ground-truth fundamental matrix should be computed, so that the dataset can be freely extended by adding further images. The proposed approach is robust to false positives occurring in the evaluation process, which do not introduce any relevant changes in the …
Recent Advances in Photocatalytic Functionalization of Quinoxalin‐2‐ones
2020
Quinoxalin‐2(1H)‐one is an important class of nitrogen heterocycle in medicinal and pharmaceutical industry, which became a synthetic target in organic chemistry in recent years. This review covers the recent advances in the functionalization of this particular nitrogen heterocycle through photocatalysis.
Epistemic Aspects of Action Systems
2015
The theory of action conventionally distinguishes real actions and doxastic (or epistemic) actions. Real actions (or as we put it—praxeological actions) bring about changes in material objects of the environment external to the agent. Epistemic actions concern mental states of agents—they bring about changes of agents’ knowledge or beliefs about the environment as well as about other beliefs. Some logical issues concerning knowledge, action, truth, and the epistemic status of agents are discussed. In this context the frame and ramification problems are also analyzed. The key issue raised in this chapter is that of non-monotonicity of reasoning. A reasoning is non-monotonic if some conclusio…
A Machine Learning-Based Prediction Platform for P-Glycoprotein Modulators and Its Validation by Molecular Docking
2019
P-glycoprotein (P-gp) is an important determinant of multidrug resistance (MDR) because its overexpression is associated with increased efflux of various established chemotherapy drugs in many clinically resistant and refractory tumors. This leads to insufficient therapeutic targeting of tumor populations, representing a major drawback of cancer chemotherapy. Therefore, P-gp is a target for pharmacological inhibitors to overcome MDR. In the present study, we utilized machine learning strategies to establish a model for P-gp modulators to predict whether a given compound would behave as substrate or inhibitor of P-gp. Random forest feature selection algorithm-based leave-one-out random sampl…
Reducing False Node Failure Predictions in HPC
2019
Future HPC applications must be able to scale to thousands of compute nodes, while running for several days. The increased runtime and node count inconveniently raises the probability of hardware failures that may interrupt computations. Scientists must therefore protect their simulations against hardware failures. This is typically done using frequent checkpoint& restart, which may have significant overheads. Consequently, the frequency in which checkpoints are taken should be minimized. Predicting hardware failures ahead of time is a promising approach to address this problem, but has remaining issues like false alarms at large scales. In this paper, we introduce the probability of unnece…
A Realistic Proposal for the Observation of Zeno Phenomena in the Dynamics of Trapped Ions
2001
A realistic experimental scheme for the observation of a continuous measurement Quantum Zeno Effect in the contest of single trapped ions is proposed. Our method relies on the nonlinearities characterizing the ionic Rabi frequency far from the Lamb-Dicke regime.
Charging process in electron conducting polymers: dimerization model
2001
Abstract Theory of the charging and discharging process in electron-conducting polymer films at an electrode surface has been presented. It is based on the concept of two coexisting subsystems at the polymer matrix, ‘usual’ sites P which can exchange with the electrode by the electronic charge in a quasi-reversible manner, and sites D where intermolecular bonds between neighboring polymer molecules can be formed. The charging and discharging of the latter subsystem may be realized along different reaction pathways, e.g. via the bond formation after the generation of two cation radicals within such site D in the course of the anodic scan while the bond dissociation may take place via a parti…
Memory effects in functionalized conducting polymer films: titanocene derivatized polypyrrole in contact with THF solutions
2003
Abstract Films with a polypyrrole matrix and pendant titanocene dichloride centers, p(Tc3Py), have been obtained by potentiostatic electropolymerization of the titanocene-pyrrolyl derivative, Tc3Py=Tc(CH 2 ) 3 NC 4 H 4 (Tc=Cl 2 TiCpCp′, Cp=C 5 H 5 , Cp′=C 5 H 4 ), in acetonitrile (AN) solutions on a Pt surface. The redox activity has been studied after the transfer of the film-coated electrode into the monomer-free solution of the same electrolyte, TBAPF 6 , in THF. Contrary to the case of AN or dichloromethane solutions, one can achieve a stable redox activity of the immobilized Tc centers in THF solutions during a series of cycles. A parallel between the redox properties of the Tc complex…
Comprehensive Study of Poly(2,3,5,6-tetrafluoroaniline): From Electrosynthesis to Heterojunctions and Ammonia Sensing.
2018
In this work, we report for the first time on a comprehensive study of poly(2,3,5,6-tetrafluoroaniline) (PTFANI). Contrary to the nonfluorinated polyaniline (PANI) or its analogues bearing one fluorine atom, PTFANI is a poorly conductive material. We present a comprehensive study of the electrosynthesized PTFANI from its monomer in an acidic aqueous medium. PTFANI was fully characterized by a potential-pH diagram, spectroelectrochemistry, and electrochemical quartz crystal microbalance (EQCM) measurements, as well as by a morphological study. Combined with the X-ray photoelectron spectroscopy (XPS) analysis, it allowed us to understand the redox properties of this polymer compared to those …